COPS3 and FLAD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COPS3	FLAD1
Description		COP9 signalosome subunit 3	flavin adenine dinucleotide synthetase 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Nucleotide Binding Catalytic Activity FMN Adenylyltransferase Activity Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding FAD Diphosphatase Activity
	Biological Process	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Protein Neddylation Regulation Of Protein Neddylation	FAD Biosynthetic Process Riboflavin Metabolic Process Flavin Adenine Dinucleotide Biosynthetic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Vitamin B2 (riboflavin) metabolism
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)	Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Refractive error ( 32231278)
Interacting Genes		32 interacting genes: ARAF ARF4 C17orf75 CEBPA CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53 UBC	21 interacting genes: ANXA7 APTX CDKN1A CLVS2 COPS3 CRABP2 DNM2 FXR1 GEMIN4 GRB7 L3MBTL3 NIF3L1 NUDT21 PRTFDC1 RCC1 REL SDCBP SMN1 TCF4 TK1 TRIM23
Entrez ID		8533	80308
HPRD ID		07262	17887
Ensembl ID		ENSG00000141030	ENSG00000160688
Uniprot IDs		B4DN01 Q9UNS2	Q8NFF5
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N 8H38 8H3A 8H3F	8ROM 8RON
Enriched GO Terms of Interacting Partners?		Protein Deneddylation Regulation Of Protein Neddylation Protein Neddylation COP9 Signalosome Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Cytosol Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Modification By Small Protein Conjugation Cytokine-mediated Signaling Pathway Post-translational Protein Modification Protein Modification Process Regulation Of Primary Metabolic Process Cytoplasm Intracellular Signal Transduction Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body ERBB Signaling Pathway Regulation Of Macromolecule Metabolic Process Intracellular Signaling Cassette Regulation Of Ubiquitin-dependent Protein Catabolic Process COP9 Signalosome Assembly Cell Surface Receptor Signaling Pathway Signal Transduction Identical Protein Binding Nucleoplasm DeNEDDylase Activity Regulation Of Proteolysis IkappaB Kinase Complex Regulation Of Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Transferrin Receptor Binding Macromolecule Metabolic Process Metal-dependent Deubiquitinase Activity Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Type II Interferon-mediated Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Protein Metabolic Process Protein Heterodimerization Activity Inflammatory Response Protein Phosphorylation Protein Binding Immune Response-activating Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Schwann Cell Development Regulation Of Intracellular Signal Transduction Phosphorylation Protein Serine/threonine Kinase Activity	Nucleus Identical Protein Binding SMN Complex Gemini Of Cajal Bodies Cytoplasm Cellular Component Assembly SMN-Sm Protein Complex Protein-containing Complex Assembly MRNA 3'-UTR AU-rich Region Binding Mitotic Cell Cycle Phase Transition Regulation Of Cell Growth Nuclear Body Cyclin Binding Cell Cycle Phase Transition Protein Sequestering Activity Protein Heterodimerization Activity Lipid Binding Protein-containing Complex Organization Interleukin-5 Receptor Complex Spliceosomal SnRNP Assembly Ribonucleoprotein Complex Binding Positive Regulation Of Pro-B Cell Differentiation DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Nucleoside Metabolic Process
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