COPS3 and MLF1

Number of citations of the paper that reports this interaction (PMID 15861129)
14

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		COPS3	MLF1
Gene Name		COP9 signalosome subunit 3	myeloid leukemia factor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm COP9 Signalosome	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Protein Binding	DNA Binding Protein Binding Protein Domain Specific Binding
	Biological Process	In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus Cullin Deneddylation	Myeloid Progenitor Cell Differentiation Transcription, DNA-templated Cell Cycle Arrest
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		20 interactors: ARAF CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS8 CSNK2A1 CSNK2B CUL5 GPS1 IKBKB IKBKG ITGB2 JUN LRP2BP MLF1 RAF1 TP53	6 interactors: CENPU COPS3 GRIK5 MAGEA11 NRBP1 YWHAZ
Entrez ID		8533	4291
HPRD ID		07262	03239
Ensembl ID		ENSG00000141030	ENSG00000178053
Uniprot IDs		Q9UNS2	B2RD48 P58340 Q2TLE4 Q5HYH4
PDB IDs			3UAL 3UBW
Enriched GO Terms of Interacting Partners?		Cullin Deneddylation Protein Deneddylation Protein Modification By Small Protein Removal Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Cellular Protein Modification Process Toll-like Receptor 4 Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Regulation Of Protein Metabolic Process Cellular Protein Metabolic Process Cellular Metabolic Process Regulation Of Intracellular Signal Transduction Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Negative Regulation Of Apoptotic Process Response To External Stimulus Negative Regulation Of Programmed Cell Death Protein Metabolic Process Regulation Of Signaling Intracellular Signal Transduction Activation Of Innate Immune Response Apoptotic Process Negative Regulation Of Cell Death Programmed Cell Death Cell Death Negative Regulation Of Cell Proliferation Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Innate Immune Response Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Phosphorylation Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Metabolic Process Fc-epsilon Receptor Signaling Pathway MAPK Cascade	Golgi Reassembly Regulation Of Synaptic Vesicle Fusion To Presynaptic Membrane Histamine Secretion By Mast Cell Establishment Of Golgi Localization Golgi Inheritance Cullin Deneddylation Histamine Secretion Protein Retention In ER Lumen Protein Deneddylation Maintenance Of Protein Localization In Endoplasmic Reticulum Histamine Transport Golgi Localization Mast Cell Degranulation Protein Localization To Organelle Production Of Molecular Mediator Involved In Inflammatory Response Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Mast Cell Mediated Immunity Establishment Of Localization In Cell CENP-A Containing Nucleosome Assembly Lysosome Localization Positive Regulation Of Apoptotic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Mast Cell Activation Positive Regulation Of Cell Death Histone Exchange Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Synaptic Vesicle Exocytosis DNA Replication-independent Nucleosome Assembly Leukocyte Degranulation Cytoplasmic Transport Regulation Of Vesicle Fusion Regulation Of Synaptic Vesicle Transport Cellular Localization Synaptic Transmission, Glutamatergic Ionotropic Glutamate Receptor Signaling Pathway Regulated Secretory Pathway Chordate Embryonic Development Centromere Complex Assembly Embryo Development Ending In Birth Or Egg Hatching
Tagcloud ?		arises arising bones ccnd1 cdk4 chromosomal chromosomes complement conventional cytogenetic decade demonstration derivative diploid homolog immunoreactivity loci locus malignancy mdm2 metaphysis monoallelic neoplastic neu osteosarcoma proximal rearrangements small tibia	akt1 akt2 aurka axon card11 deregulated exclusive exome fgfr2 grouping hook3 integrative massively men1 mutually nets neuroendocrine nono pdgfr preponderance provisional recurrently si smad smad1 snvs therapeutically transitions vhl
Tagcloud (Difference) ?		arises arising bones ccnd1 cdk4 chromosomal chromosomes complement conventional cytogenetic decade demonstration derivative diploid homolog immunoreactivity loci locus malignancy mdm2 metaphysis monoallelic neoplastic neu osteosarcoma proximal rearrangements small tibia	akt1 akt2 aurka axon card11 deregulated exclusive exome fgfr2 grouping hook3 integrative massively men1 mutually nets neuroendocrine nono pdgfr preponderance provisional recurrently si smad smad1 snvs therapeutically transitions vhl
Tagcloud (Intersection) ?