OGT and YES1

Number of citations of the paper that reports this interaction (PMID 16434389)
23

Data Source:
BioGRID (enzymatic study)

		OGT	YES1
Gene Name		O-linked N-acetylglucosamine (GlcNAc) transferase	YES proto-oncogene 1, Src family tyrosine kinase
Image
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Microtubule Organizing Center Cytosol Plasma Membrane MLL5-L Complex	Cytoplasm Golgi Apparatus Microtubule Organizing Center Cytosol Actin Filament Plasma Membrane Focal Adhesion Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Enzyme Activator Activity Acetylglucosaminyltransferase Activity Protein N-acetylglucosaminyltransferase Activity Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific) Protein O-GlcNAc Transferase Activity	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Binding Epidermal Growth Factor Receptor Binding Protein Binding ATP Binding Enzyme Binding Ion Channel Binding
	Biological Process	Regulation Of Glycolytic Process Chromatin Organization Protein O-linked Glycosylation Apoptotic Process Signal Transduction Response To Nutrient Positive Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Rac Protein Signal Transduction Positive Regulation Of Catalytic Activity Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K27 Methylation Cellular Response To Retinoic Acid Histone H3-K4 Trimethylation Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis	Cellular Protein Modification Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Axon Guidance Blood Coagulation Glucose Transport Cell Differentiation T Cell Costimulation Cellular Response To Platelet-derived Growth Factor Stimulus Peptidyl-tyrosine Autophosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Cell Proliferation Regulation Of Vascular Permeability Innate Immune Response Ephrin Receptor Signaling Pathway Leukocyte Migration Cellular Response To Peptide Hormone Stimulus
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	Axon guidance Costimulation by the CD28 family EPHB-mediated forward signaling Signaling by SCF-KIT EPHA-mediated growth cone collapse Regulation of KIT signaling EPH-ephrin mediated repulsion of cells Regulation of signaling by CBL EPH-Ephrin signaling Fcgamma receptor (FCGR) dependent phagocytosis FCGR activation Innate Immune System CTLA4 inhibitory signaling CD28 co-stimulation Cytokine Signaling in Immune system PECAM1 interactions Cell surface interactions at the vascular wall Signaling by ERBB2 Signaling by Interleukins Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System
Drugs			Dasatinib
Diseases
GWAS			Pulmonary function in asthmatics ( 23541324)
Protein-Protein Interactions		18 interactors: CSNK2A1 GSK3B HCFC1 MAPT MGEA5 NUP62 NUP62CL PHC3 PSG1 SIN3A SNAP91 SP1 SRF TAB1 TET2 TRAK1 TRAK2 YES1	49 interactors: ADAM12 ADAM15 C1orf94 CBL CD2AP CD36 CD46 CDH1 CDKN1B CSF1R DLG4 DOK1 EPHB2 FASLG FLT1 FUNDC1 FXR2 GP6 ITGB4 JAK2 KDR KHDRBS1 KIT MST1R NEDD4 NIF3L1 NPHS1 OGT PAK2 PDCD6IP PDGFRB PECAM1 PTK2 PTPRE RASA1 RPL10 SLC9A3R1 SOCS3 SPRR2A SSBP3 THAP1 TNK2 TP53BP2 TRAF2 TRAF6 TRPV4 TYRO3 ZBTB8A ZNF512B
Entrez ID		8473	7525
HPRD ID		02222	01285
Ensembl ID		ENSG00000147162	ENSG00000176105
Uniprot IDs		O15294	P07947
PDB IDs		1W3B 3PE3 3PE4 3TAX 4AY5 4AY6 4GYW 4GYY 4GZ3 4GZ5 4GZ6	2HDA
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Growth Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Axon Extension Regulation Of Axon Extension Positive Regulation Of Growth Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Axonogenesis Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Protein O-linked Glycosylation Protein Transport Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Establishment Of Protein Localization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Aging Regulation Of RNA Metabolic Process Developmental Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Complex Assembly Regulation Of Cell Growth Regulation Of Cell Size Megakaryocyte Differentiation Cell Morphogenesis Involved In Differentiation Trophectodermal Cell Differentiation Histone Modification Anatomical Structure Morphogenesis Regulation Of Gene Expression Cellular Protein Modification Process Positive Regulation Of Developmental Growth Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Neuron Projection Development Positive Regulation Of Protein Complex Assembly Glycoprotein Metabolic Process Negative Regulation Of Protein Metabolic Process Blastocyst Formation Regulation Of Metabolic Process In Utero Embryonic Development	Enzyme Linked Receptor Protein Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signal Transduction Positive Regulation Of Protein Metabolic Process Signaling Regulation Of Signal Transduction Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Signaling Cell Communication Regulation Of Phosphatidylinositol 3-kinase Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Metabolic Process Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Positive Regulation Of Signal Transduction Cellular Response To Stimulus Positive Regulation Of Intracellular Signal Transduction Immune System Process Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Protein Metabolic Process Protein Autophosphorylation Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Regulation Of Cellular Component Organization Innate Immune Response Response To Stimulus Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Phosphorylation Regulation Of Cellular Process Locomotion Intracellular Signal Transduction Immune Response Regulation Of Phosphorylation Positive Regulation Of Cell Proliferation Positive Regulation Of Metabolic Process Cell Differentiation Positive Regulation Of Phosphorylation Regulation Of Catalytic Activity Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Regulation Of Immune System Process Regulation Of Kinase Activity Positive Regulation Of Cellular Metabolic Process Response To Stress Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Organic Substance System Development Regulation Of Cellular Component Movement Regulation Of Immune Response Positive Regulation Of Transferase Activity
Tagcloud ?		acetylglucosamine aggregates autophagic autophagosome autophagosomes autophagy caenorhabditis defective elegans endosomes facilitates flux glcnac glcnacylated glcnacylation integrates lysosomes mammalian mediates mutating nutrient promotes regulates reveals snap snare starvation transferase	answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele
Tagcloud (Difference) ?		acetylglucosamine aggregates autophagic autophagosome autophagosomes autophagy caenorhabditis defective elegans endosomes facilitates flux glcnac glcnacylated glcnacylation integrates lysosomes mammalian mediates mutating nutrient promotes regulates reveals snap snare starvation transferase	answered antiapoptotic coculture defensive deregulated dramatic heat hyperthermia indicative indispensable insult mechanistically meiotic mta1 naturally negligible nonreceptor pachytene paracrine ps scs sertoli spermatocytes standpoint su6656 testicular testis thereafter varicocele
Tagcloud (Intersection) ?