OGT and TET2

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		OGT	TET2
Gene Name		O-linked N-acetylglucosamine (GlcNAc) transferase	tet methylcytosine dioxygenase 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Microtubule Organizing Center Cytosol Plasma Membrane MLL5-L Complex
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Enzyme Activator Activity Acetylglucosaminyltransferase Activity Protein N-acetylglucosaminyltransferase Activity Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific) Protein O-GlcNAc Transferase Activity	DNA Binding Protein Binding Ferrous Iron Binding Zinc Ion Binding Methylcytosine Dioxygenase Activity
	Biological Process	Regulation Of Glycolytic Process Chromatin Organization Protein O-linked Glycosylation Apoptotic Process Signal Transduction Response To Nutrient Positive Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Rac Protein Signal Transduction Positive Regulation Of Catalytic Activity Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation Positive Regulation Of Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of Histone H3-K27 Methylation Cellular Response To Retinoic Acid Histone H3-K4 Trimethylation Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis	Kidney Development Myeloid Progenitor Cell Differentiation 5-methylcytosine Catabolic Process Protein O-linked Glycosylation Cell Cycle Post-embryonic Development Gene Expression Cytosine Metabolic Process Hemoglobin Metabolic Process Myeloid Cell Differentiation Oxidative DNA Demethylation Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Hematopoietic Stem Cell Homeostasis Liver Morphogenesis DNA Demethylation Histone H3-K4 Trimethylation
Pathways		Chromatin modifying enzymes Chromatin organization HATs acetylate histones	TET1,2,3 and TDG demethylate DNA Epigenetic regulation of gene expression
Drugs
Diseases
GWAS			Breast cancer ( 23535729) Height ( 20881960) Immune response to anthrax vaccine ( 22658931) Prostate cancer ( 19767753) Pulmonary function ( 21946350)
Protein-Protein Interactions		18 interactors: CSNK2A1 GSK3B HCFC1 MAPT MGEA5 NUP62 NUP62CL PHC3 PSG1 SIN3A SNAP91 SP1 SRF TAB1 TET2 TRAK1 TRAK2 YES1	2 interactors: OGT TBC1D4
Entrez ID		8473	54790
HPRD ID		02222	07876
Ensembl ID		ENSG00000147162	ENSG00000168769
Uniprot IDs		O15294	Q6N021
PDB IDs		1W3B 3PE3 3PE4 3TAX 4AY5 4AY6 4GYW 4GYY 4GZ3 4GZ5 4GZ6
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Growth Hematopoietic Progenitor Cell Differentiation Positive Regulation Of Axon Extension Regulation Of Axon Extension Positive Regulation Of Growth Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Axonogenesis Positive Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Protein Localization Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Protein O-linked Glycosylation Protein Transport Positive Regulation Of Metabolic Process Regulation Of Transcription, DNA-templated Establishment Of Protein Localization Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Rhythmic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Aging Regulation Of RNA Metabolic Process Developmental Process Positive Regulation Of Cellular Biosynthetic Process Regulation Of Protein Complex Assembly Regulation Of Cell Growth Regulation Of Cell Size Megakaryocyte Differentiation Cell Morphogenesis Involved In Differentiation Trophectodermal Cell Differentiation Histone Modification Anatomical Structure Morphogenesis Regulation Of Gene Expression Cellular Protein Modification Process Positive Regulation Of Developmental Growth Regulation Of Axonogenesis Positive Regulation Of Cell Morphogenesis Involved In Differentiation Response To Organic Substance Negative Regulation Of Cellular Protein Metabolic Process Cellular Response To Organic Substance Neuron Projection Development Positive Regulation Of Protein Complex Assembly Glycoprotein Metabolic Process Negative Regulation Of Protein Metabolic Process Blastocyst Formation Regulation Of Metabolic Process In Utero Embryonic Development	Response To Insulin Regulation Of Gluconeogenesis Involved In Cellular Glucose Homeostasis Response To Peptide Hormone Response To Peptide Negative Regulation Of Vesicle Fusion Positive Regulation Of Granulocyte Differentiation Regulation Of Ras Protein Signal Transduction Positive Regulation Of Histone H3-K27 Methylation Regulation Of Small GTPase Mediated Signal Transduction Histone H3-K4 Trimethylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Regulation Of Histone H3-K27 Methylation Histone H4-K16 Acetylation Response To Organonitrogen Compound Positive Regulation Of Histone H3-K4 Methylation Regulation Of Organelle Organization Response To Hormone Regulation Of Histone H3-K4 Methylation Regulation Of Glycolytic Process Peptidyl-lysine Trimethylation Histone H3-K4 Methylation Regulation Of Rac Protein Signal Transduction Regulation Of Vesicle Fusion Positive Regulation Of Histone Methylation Regulation Of Gluconeogenesis Positive Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Catalytic Activity Histone H4 Acetylation Regulation Of Histone Methylation Regulation Of Insulin Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Retinoic Acid Positive Regulation Of Histone Modification Regulation Of Generation Of Precursor Metabolites And Energy Cellular Glucose Homeostasis Cellular Response To Organic Substance Positive Regulation Of Myeloid Cell Differentiation Circadian Regulation Of Gene Expression Regulation Of Cellular Component Organization Regulation Of Cellular Response To Insulin Stimulus Protein O-linked Glycosylation Histone Lysine Methylation Peptidyl-lysine Methylation Negative Regulation Of Protein Ubiquitination Regulation Of Glucose Metabolic Process Regulation Of Myeloid Leukocyte Differentiation Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation
Tagcloud ?		acetylglucosamine aggregates autophagic autophagosome autophagosomes autophagy caenorhabditis defective elegans endosomes facilitates flux glcnac glcnacylated glcnacylation integrates lysosomes mammalian mediates mutating nutrient promotes regulates reveals snap snare starvation transferase	abstract advancements ascribed asxl1 attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating idh2 incurable optimize overview profoundly renders sf3b1 sibling spite stratify transplant video wider
Tagcloud (Difference) ?		acetylglucosamine aggregates autophagic autophagosome autophagosomes autophagy caenorhabditis defective elegans endosomes facilitates flux glcnac glcnacylated glcnacylation integrates lysosomes mammalian mediates mutating nutrient promotes regulates reveals snap snare starvation transferase	abstract advancements ascribed asxl1 attitude azacitidine challenging changing choices conditioning curative decitabine feasible haploidentical hematologists hypomethylating idh2 incurable optimize overview profoundly renders sf3b1 sibling spite stratify transplant video wider
Tagcloud (Intersection) ?