OGT and TERF1

Number of citations of the paper that reports this interaction (PubMedID 32994395)
54

Data Source:
BioGRID (pull down)

		OGT	TERF1
Description		O-linked N-acetylglucosamine (GlcNAc) transferase	telomeric repeat binding factor 1
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GO Annotations	Cellular Component	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Membrane Protein N-acetylglucosaminyltransferase Complex Mitochondrial Membrane Protein-containing Complex Cell Projection NSL Complex Synapse Sin3-type Complex Glutamatergic Synapse	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Spindle Cytoskeleton Nuclear Body Shelterin Complex
	Molecular Function	Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Lipid Binding Acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Chromatin DNA Binding Protein O-acetylglucosaminyltransferase Activity	DNA Binding Double-stranded Telomeric DNA Binding Telomerase Activity Protein Binding Microtubule Binding DNA Binding, Bending Telomeric DNA Binding Identical Protein Binding Protein Homodimerization Activity Ankyrin Repeat Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Mitophagy Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Cytoplasmic Translation Regulation Of Glycolytic Process Regulation Of Gluconeogenesis Chromatin Organization Regulation Of Transcription By RNA Polymerase II Protein Glycosylation Protein O-linked Glycosylation Apoptotic Process Signal Transduction Response To Nutrient Protein Processing Negative Regulation Of Translation Hemopoiesis Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Ubiquitination Cellular Response To Nutrient Levels Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Rac Protein Signal Transduction TORC1 Signaling Positive Regulation Of Translation Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Lipid Biosynthetic Process Rhythmic Process Protein Maturation Regulation Of Synapse Assembly Regulation Of Necroptotic Process Protein Localization To Lysosome Pyroptotic Inflammatory Response Cellular Response To Glucose Stimulus Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Cold-induced Thermogenesis Membraneless Organelle Assembly Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Negative Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Population Maintenance Positive Regulation Of TORC1 Signaling	Telomere Maintenance Telomere Maintenance Via Telomerase Negative Regulation Of DNA Replication Response To Xenobiotic Stimulus Telomere Capping Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Meiotic Telomere Clustering Cell Division Telomeric D-loop Disassembly T-circle Formation Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Shelterin Complex Assembly Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Telomeric D-loop Disassembly
Pathways		HATs acetylate histones RIPK1-mediated regulated necrosis Regulation of necroptotic cell death UCH proteinases Formation of WDR5-containing histone-modifying complexes	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Red cell distribution width ( 32888494)	Age at first sexual intercourse ( 34211149) Crohn's disease ( 22412388) Leukocyte telomere length ( 31171785) Telomere length ( 33941849)
Interacting Genes		717 interacting genes: - AAMP AARSD1 AASS ABI1 ABI2 ABRAXAS1 ABRAXAS2 ACOX1 ACTB ACTC1 ACTL6A ACTR3 ADPGK ADSL AGFG1 AHSA1 ALDH1A2 ALDH1B1 ALDH2 ALDH4A1 ALDH5A1 ALDH6A1 ALDH7A1 ALDOA ALKBH5 ANAPC7 ANXA11 ANXA6 ANXA7 API5 APMAP APOH ARHGAP1 ARHGAP19 ARIH2 ARMC6 ASCC1 ASPH ATAD3A ATIC ATL2 ATL3 ATP1B1 ATP1B3 ATP5F1A ATP5F1B ATP6AP1 ATXN10 ATXN2L B3GLCT B4GAT1 BAG1 BAIAP2 BCCIP BCLAF1 BEND7 BIRC5 BSG BTG3 BYSL BZW2 C17orf75 CAAP1 CALR CARS2 CASP8 CAT CAVIN1 CBLL1 CBR1 CCDC47 CCDC77 CCDC86 CCNB1 CCT2 CCT3 CCT4 CCT5 CCT6A CCT7 CCT8 CD2BP2 CDC37 CDC42EP1 CDC5L CDC6 CDK9 CDKAL1 CELF1 CENPU CEP43 CEP55 CEP57 CHMP7 CHST7 CIRSR CKAP4 CKB CKMT1A CLCC1 CLN5 CLPB CLPX CNDP2 CNOT11 COIL COPS2 COQ8B CPSF6 CPSF7 CREBBP CRTAP CSNK1G2 CSNK2A1 CSNK2B CTSD CTU2 CWC25 CWC27 CXADR DAPK3 DAZAP1 DBN1 DBNL DBT DCTN2 DDX17 DDX28 DDX39B DDX3X DDX41 DDX47 DDX5 DDX56 DEK DHX30 DHX9 DLD DLG3 DLST DMAP1 DNAJA1 DNAJA2 DNAJC3 DNAJC7 DUS1L DYNC1LI1 DYNC1LI2 EARS2 ECSIT EDC3 EEF1A1 EEF1G EHD1 EIF2AK2 EIF2S2 EIF3D EIF3E EIF3F EIF3G EIF4A1 EIF4G2 EIF5 ELOA ENO1 ERGIC3 ERI1 ERO1A ERO1B ESS2 ETF1 EWSR1 FAF2 FAM199X FAM98A FARSA FDXR FEN1 FH FILNC1 FIP1L1 FIZ1 FKBP10 FKBP4 FKBP5 FKBP8 FNTA FTO FTSJ3 FUBP3 FUCA1 FUCA2 FUS G3BP1 G3BP2 GABPA GAPDH GART GATA6 GATB GBA1 GDI1 GDI2 GLA GLMN GLS GLUD1 GNL3 GORASP2 GPATCH4 GPKOW GPS1 GPT2 GRSF1 GRWD1 GSK3A GSK3B GSS GSTM3 GSTP1 GTF2E1 GTF2H1 GTF3C5 GTPBP3 GXYLT1 H1-4 HABP4 HARS1 HARS2 HAUS8 HCFC1 HGH1 HIRA HIVEP1 HMGCS1 HNRNPA1 HNRNPA2B1 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPF HNRNPH1 HNRNPH2 HNRNPK HNRNPL HNRNPM HNRNPR HP1BP3 HS2ST1 HSP90AB1 HSP90B1 HSPA13 HSPA14 HSPA1A HSPA9 HSPD1 IFRD2 IGF2BP1 IGF2BP2 IGF2BP3 IGKV2D-29 IK IKBIP ILF2 ILF3 ILK ILKAP IMPDH1 IMPDH2 IPO5 IRF3 IRS4 IST1 ISYNA1 JMJD6 KARS1 KATNA1 KHDRBS1 KHDRBS3 KNOP1 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 KPNB1 KRR1 KRT1 KRT10 KRT2 KRT8 KRT9 LACTB LAP3 LARP4B LDHB LEMD2 LENG9 LETM1 LMAN1 LMNA LNPK LPCAT1 LPCAT4 LRP4 LRRFIP2 LSM14A LSM14B LSR LTV1 LUC7L2 LUC7L3 LYAR MAP1A MAP7D1 MAPT MARS2 MAT2A MAZ MCCC2 ME1 ME2 MEAK7 METAP2 MFAP1 MICU1 MINPP1 MPP1 MRM3 MSTO1 MTDH MYEF2 NAE1 NAMPT NAP1L1 NAP1L4 NASP NCL NDUFV1 NELFCD NHERF1 NISCH NKAP NOC4L NOLC1 NOM1 NONO NOP53 NOP58 NPM1 NSMCE4A NSUN5 NSUN6 NT5DC1 NUDC NUF2 NUFIP1 NUFIP2 NUP50 NUP54 NUP62 NUP62CL NUSAP1 NXN OAT OCLN OGA OLA1 OXCT1 OXSR1 P3H4 P4HA1 P4HA2 P4HB PA2G4 PABPC1 PABPC4 PABPN1 PACSIN3 PAIP1 PAK2 PALS2 PARD6B PARG PARP1 PARVA PCBP1 PCBP2 PCGF2 PCGF6 PCYOX1 PDCD2L PDCD4 PDCD7 PDHX PDIA3 PDIA5 PDIA6 PDP1 PEX14 PGD PGK1 PGM1 PHAX PHC3 PHF10 PHF6 PHGDH PI4K2A PICALM PIP4K2C PKM PKP4 PLD3 PLEKHO1 PLIN2 PLS3 PM20D2 PMPCA PNKP PNMA8A POGLUT3 POLD2 POLDIP3 POLM POLR1E POLR3C POLR3D POMK PPAT PPHLN1 PPM1F PPP1R7 PPP2R1A PPP2R1B PPP2R5C PPP2R5E PPP3CA PPP5C PRC1 PRCP PRIM1 PRIM2 PRKAR1A PRKAR2A PRKAR2B PRORP PRPF19 PRPF31 PRRC1 PSG1 PSIP1 PSMC1 PSMC2 PSMC3 PSMC4 PSMC5 PSMD12 PSMD4 PTBP1 PTBP2 PUF60 PURA PWP1 QRSL1 RAB11FIP2 RAD23A RAD23B RANGAP1 RAP1GDS1 RARS1 RARS2 RBFOX2 RBM17 RBM22 RBM23 RBM39 RBM42 RBM45 RBMS1 RBMX RCC1 RCN2 REPIN1 REXO4 RIC8A RING1 RIOX2 RNH1 RNPS1 RO60 RPL10 RPL10A RPL11 RPL12 RPL13 RPL22 RPL24 RPL3 RPL30 RPL4 RPL5 RPL6 RPL7 RPL8 RPL9 RPLP0 RPS2 RPS24 RPS3 RPS3A RPS4X RPS7 RPSA RPTOR RRP1 RRP1B RRP8 RRS1 RSRC2 RTCB RTN4 RUVBL1 RUVBL2 SAAL1 SAP30BP SARS2 SCAI SCLY SCP2 SCRIB SCRN1 SDE2 SEC62 SENP2 SEPTIN11 SEPTIN7 SERBP1 SERPINH1 SETD7 SF1 SF3A2 SF3A3 SF3B4 SFPQ SGSH SH3GLB2 SHMT2 SHOC2 SIN3A SLIT2 SMARCD1 SMARCD2 SMARCE1 SMPDL3B SNAP91 SNRNP70 SNW1 SNX4 SNX5 SNX6 SP1 SPAST SPATS2 SPATS2L SPOUT1 SQSTM1 SRF SRFBP1 SRP54 SRP68 SRP72 SRSF11 SRSF6 SRSF7 SSB ST13 STAU1 STAU2 STIP1 STK24 STK25 STK26 STK3 STK4 STOML2 SVOP SYAP1 SYNCRIP TAB1 TAB3 TADA2B TADA3 TAF15 TAF7 TARBP2 TBCE TBCEL TBL1XR1 TCP1 TCP11L1 TEDC1 TEDC2 TENT2 TERF1 TET2 TFDP1 TFG THRAP3 THUMPD1 TMCC3 TMEM30A TMPO TMX3 TOE1 TOM1 TOMM70 TOR1AIP1 TOR1AIP2 TP53 TPP1 TRAF4 TRAF7 TRAK1 TRAK2 TRIM11 TRIM27 TRIM28 TRIP12 TRIT1 TRMT10C TRMT5 TRMT6 TSG101 TSPYL1 TTC31 TTC4 TUBA1A TUBA1B TUBA1C TUBA4A TUBB TUBB2A TUBB2B TUBB3 TUBB4A TUBB4B TUBB6 TUBG1 TUFM TXNDC5 U2AF2 UBA1 UBA3 UBA5 UBC UBE2Q1 UBR7 UBXN6 UCHL5 UMPS UPF3B UQCRC1 USP14 UTP18 UTP3 VEZF1 VIM VIPAS39 VPS4A VPS4B VRK1 VRK2 VRK3 WARS1 WBP4 WDR55 WT1 WTAP XIAP XPO1 XRCC4 XRCC6 XRN2 YARS1 YBX1 YBX3 YES1 YJU2B YME1L1 YTHDF2 ZBTB14 ZC3H15 ZC3HAV1 ZCCHC3 ZKSCAN4 ZKSCAN8 ZNF124 ZNF207 ZNF277 ZNF385A ZNF397 ZNF436 ZNF460 ZNF48 ZNF622 ZNF70 ZNF703 ZNF768 ZNF787 ZNG1F ZNHIT2 ZPR1 ZRANB2 ZSCAN21	212 interacting genes: ACAT2 ACOT7 ACY1 AFAP1L2 AHCY AK1 AKR1A1 ALDOA AMPD2 AMPH ANXA2 ANXA5 ANXA8L1 APEX1 ARHGDIA ARHGEF3 ARPP21 ASS1 ATM BCL7B BIN2 BLM BRAF C12orf43 C1orf35 CALD1 CAPNS1 CASP7 CCDC9 CDC6 CDK1 CEP85 CFL1 CKB CORO1B CPNE3 CRYBB1 CRYM DBN1 DBNL DCX DDX19B DDX21 DDX23 DDX24 DDX39A DLG5 DNAAF11 DNAJB1 DNPH1 DPP3 DPYSL3 EEF1D EIF4B ENO2 EPB41L1 EPHX2 EVL FANCD2 FBP1 FBXO4 FEN1 FES FKBP8 GAMT GAPDH GIT1 GNL3L GNMT GSS H1-1 HCLS1 HDGFL2 HEXIM1 HEXIM2 HGD HMGN3 HMGN4 HMOX1 HNMT HOXA3 HSP90AB1 HSPA6 IPO5 JSRP1 KCTD7 KDM1A KEAP1 KIFBP KLHDC4 KPNB1 LASP1 LDHA LDHB LRSAM1 LYAR MAP4 MAP7 MAPK12 MAPRE1 MCM2 MDH1 MISP MSN MT1X MVK NAP1L1 NBN NEFL NEK7 NME1 NME2 NOL12 NOL3 NRIP1 NUDCD2 NUDT14 NUMA1 NXNL1 OCM2 OGFR OGT PA2G4 PACSIN2 PAFAH1B3 PAGE2 PAICS PAK4 PCLAF PCP4 PEPD PFKP PFN2 PGD PGLS PGM1 PGM2 PINX1 PKM PNMT POT1 PPM1G PRDX1 PRDX6 PRKCB PTMA PTPN5 RBMY1A1 RECQL4 RIC8A RLIM RNF10 RPAP3 RPL19 RTN3 RTN4 SALL1 SARS1 SBDS SENP8 SET SH3BP1 SH3GL2 SH3GL3 SHFL SIRPD SKP1 SMAD9 SMARCC2 SNCG SOAT1 SP100 SRM SRSF6 STUB1 SULT1C2 SUPT5H SYK TALDO1 TBC1D10A TBCD TBL1X TCIRG1 TERT THG1L TINAG TINF2 TKT TMSB10 TMSB4Y TNKS TNKS2 TNPO2 TOMM34 TPI1 TRIM16 TRIP10 TRMT1 TUBB2A TUBB3 TUBB4B UBE2M UTP14A WARS1 WDR4 WFS1 YWHAG ZBTB16 ZC3H18 ZFP36L1 ZHX1 ZNF790
Entrez ID		8473	7013
HPRD ID		02222	02975
Ensembl ID		ENSG00000147162	ENSG00000147601
Uniprot IDs		O15294	A0A7I2V5T5 A0A7I2YQE7 P54274
PDB IDs		1W3B 3PE3 3PE4 3TAX 4AY5 4AY6 4CDR 4GYW 4GYY 4GZ3 4GZ5 4GZ6 4N39 4N3A 4N3B 4N3C 4XI9 4XIF 5BNW 5C1D 5HGV 5LVV 5LWV 5NPR 5NPS 5VIE 5VIF 6E37 6EOU 6IBO 6MA1 6MA2 6MA3 6MA4 6MA5 6Q4M 6TKA 7NTF 7YEA 7YEH 8CM9 8FE6 8FE7 8FUF	1BA5 1H6O 1ITY 1IV6 1W0T 3BQO 3L82 5HKP 5WIR 5XUP 8F0A 8F0U 8F1T 8F1U 8F21 8F26 8OX1 8W8G
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleus RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process RNA Processing Macromolecule Metabolic Process Cytoplasm Ribonucleoprotein Complex Nucleoplasm Nucleic Acid Binding Cytosol MRNA Metabolic Process MRNA Processing RNA Splicing Extracellular Exosome MRNA Binding Protein Folding Nucleolus Regulation Of RNA Splicing MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Translation Protein Binding Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of Translation Spliceosomal Complex Regulation Of MRNA Splicing, Via Spliceosome Cadherin Binding Post-transcriptional Regulation Of Gene Expression Protein-RNA Complex Assembly Nucleotide Binding Macromolecule Biosynthetic Process Cytosolic Ribosome Unfolded Protein Binding Protein-containing Complex Organization Protein Folding Chaperone ATP-dependent Protein Folding Chaperone Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Nuclear Speck Regulation Of Chromosome Organization Protein-containing Complex Biological_process RRNA Metabolic Process Cytoplasmic Stress Granule Protein-containing Complex Assembly ATP Binding Negative Regulation Of MRNA Metabolic Process	Cytosol Cytoplasm Extracellular Exosome Identical Protein Binding Protein Binding Nucleobase-containing Compound Metabolic Process Nicotinamide Nucleotide Metabolic Process Telomere Maintenance Chromosome, Telomeric Region Nucleobase-containing Small Molecule Metabolic Process Purine-containing Compound Metabolic Process Telomere Organization Cadherin Binding Nucleus Negative Regulation Of Telomere Maintenance Purine Nucleotide Metabolic Process ADP Metabolic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Chromosome Organization Positive Regulation Of Chromosome Organization Nucleoside Diphosphate Metabolic Process Glycolytic Process Pyruvate Metabolic Process Positive Regulation Of Cellular Component Organization Regulation Of Cellular Component Organization ADP Catabolic Process Nucleotide Metabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Ribonucleoside Diphosphate Catabolic Process Nucleoside Phosphate Metabolic Process Ficolin-1-rich Granule Lumen Nucleoside Diphosphate Catabolic Process Ribonucleoside Diphosphate Metabolic Process Nucleoside Phosphate Catabolic Process RNA Binding Phosphate-containing Compound Metabolic Process Microtubule Cytoskeleton Organization Negative Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Purine Nucleotide Catabolic Process Protein Localization To Organelle Positive Regulation Of Protein-containing Complex Assembly Cytoskeleton Positive Regulation Of Organelle Organization Organelle Organization Catalytic Activity Small Molecule Metabolic Process Organophosphate Catabolic Process
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