USP13 and MYO15A

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		USP13	MYO15A
Gene Name		ubiquitin specific peptidase 13 (isopeptidase T-3)	myosin XVA
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Lysosome	Cytoplasm Myosin Complex Stereocilium Extracellular Vesicular Exosome
	Molecular Function	Cysteine-type Endopeptidase Activity Ubiquitin-specific Protease Activity Protein Binding Omega Peptidase Activity Zinc Ion Binding Ubiquitin Protein Ligase Binding Ubiquitin Binding	Motor Activity Actin Binding Calmodulin Binding ATP Binding
	Biological Process	Regulation Of Transcription, DNA-templated Autophagy Cell Proliferation Regulation Of Autophagy Melanocyte Differentiation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Regulation Of Proteasomal Protein Catabolic Process Protein K63-linked Deubiquitination	Sensory Perception Of Sound Locomotory Behavior Metabolic Process Inner Ear Morphogenesis
Pathways
Drugs
Diseases
GWAS			Obesity-related traits ( 23251661)
Protein-Protein Interactions		12 interactors: DVL1 FNBP1L FUNDC2 LAPTM5 MRPL20 MYO15A PTEN SIAH2 SPRR2C TRIM55 TRIM63 UBC	4 interactors: DFNB31 EPS8 FASLG USP13
Entrez ID		8975	51168
HPRD ID		04666	04049
Ensembl ID		ENSG00000058056	ENSG00000091536
Uniprot IDs		Q92995	Q9UKN7
PDB IDs		2L80 2LBC
Enriched GO Terms of Interacting Partners?		Prepulse Inhibition Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cellular Protein Catabolic Process Catabolic Process Startle Response Negative Regulation Of Wnt Signaling Pathway Regulation Of Protein Ubiquitination Positive Regulation Of Protein Catabolic Process Regulation Of Canonical Wnt Signaling Pathway Social Behavior Regulation Of Proteolysis Positive Regulation Of Proteolysis Negative Regulation Of Transferase Activity Regulation Of Wnt Signaling Pathway Negative Regulation Of Catalytic Activity Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition Negative Regulation Of Cellular Protein Metabolic Process Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Cell Projection Morphogenesis Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Membrane Organization Cell Part Morphogenesis Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Metabolic Process Positive Regulation Of Ligase Activity Regulation Of Protein Catabolic Process Dendrite Morphogenesis Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Canonical Wnt Signaling Pathway Activation Of APC-Cdc20 Complex Activity Postsynaptic Density Assembly Negative Regulation Of Presynaptic Membrane Organization Inner Ear Morphogenesis Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Cell Morphogenesis Negative Regulation Of Signal Transduction T Cell Receptor Signaling Pathway Regulation Of Cell Projection Organization Ubiquitin-dependent Protein Catabolic Process Cell Projection Organization Convergent Extension Involved In Neural Plate Elongation Negative Regulation Of Dendritic Spine Morphogenesis Vesicle Transport Along Actin Filament Modification-dependent Protein Catabolic Process	Endosomal Lumen Acidification Actin Polymerization-dependent Cell Motility Retinal Cell Programmed Cell Death Necroptotic Signaling Pathway Exit From Mitosis Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Behavioral Response To Ethanol Chloride Ion Homeostasis Positive Regulation Of Endothelial Cell Apoptotic Process Rac Protein Signal Transduction Protein K63-linked Deubiquitination T Cell Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Inner Ear Receptor Stereocilium Organization Intracellular PH Reduction Barbed-end Actin Filament Capping Actin Crosslink Formation Sensory Organ Development Dendritic Cell Migration PH Reduction Positive Regulation Of ERBB Signaling Pathway Regulation Of Proteolysis Endosome Organization Necroptotic Process Cell Proliferation Regulation Of Endothelial Cell Apoptotic Process
Tagcloud ?		adamts2 aldh1a3 alpl2 apod cabin1 casp10 cdh16 classes classifier clgn covering crabp1 dataset datasets enrichments follicular gnas hmgb2 krthb5 microfollicular nr2f2 nras pax8 predictions sdha separating similarities subclasses timp1
Tagcloud (Difference) ?		adamts2 aldh1a3 alpl2 apod cabin1 casp10 cdh16 classes classifier clgn covering crabp1 dataset datasets enrichments follicular gnas hmgb2 krthb5 microfollicular nr2f2 nras pax8 predictions sdha separating similarities subclasses timp1
Tagcloud (Intersection) ?