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SKP1 and CUL7
Number of citations of the paper that reports this interaction (PubMedID
10531037
)
0
Data Source:
HPRD
(two hybrid, in vitro, in vivo)
SKP1
CUL7
Description
S-phase kinase associated protein 1
cullin 7
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Anaphase-promoting Complex
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Cytoskeleton
Cullin-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Perinuclear Region Of Cytoplasm
3M Complex
Molecular Function
Protein Binding
Beta-catenin Binding
Protein Domain Specific Binding
Cullin Family Protein Binding
Molecular Function Activator Activity
Ubiquitin Ligase Complex Scaffold Activity
F-box Domain Binding
Ubiquitin-like Ligase-substrate Adaptor Activity
Ubiquitin Ligase Activator Activity
Protein Binding
Ubiquitin Protein Ligase Binding
Ubiquitin Ligase Complex Scaffold Activity
Biological Process
Protein Polyubiquitination
Chromatin Remodeling
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Apoptotic Process
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Maintenance Of Protein Location In Nucleus
Axon Development
Protein K48-linked Ubiquitination
Positive Regulation Of Epithelial Cell Apoptotic Process
Microtubule Cytoskeleton Organization
Mitotic Cytokinesis
Vasculogenesis
Epithelial To Mesenchymal Transition
Placenta Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Golgi Organization
Regulation Of Mitotic Nuclear Division
Insulin Receptor Signaling Pathway
Protein Ubiquitination
Negative Regulation Of Insulin Receptor Signaling Pathway
Positive Regulation Of Dendrite Morphogenesis
Pathways
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Regulation of BACH1 activity
Nuclear events stimulated by ALK signaling in cancer
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
Antigen processing: Ubiquitination & Proteasome degradation
GSK3B-mediated proteasomal degradation of PD-L1(CD274)
Degradation of CRY and PER proteins
XBP1(S) activates chaperone genes
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
1-naphthaleneacetic acid
(2S)-2-(1H-indol-3-yl)hexanoic acid
(2S)-2-(1H-indol-3-yl)pentanoic acid
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
Indoleacetic acid
Diseases
3M syndrome
GWAS
Mean platelet volume (
32888494
)
Systemic lupus erythematosus (
26502338
27399966
)
Appendicular lean mass (
33097823
)
Interacting Genes
75 interacting genes:
ANKRD36BP1
APIP
BTRC
CACYBP
CAND1
CCNA2
CDCA3
CDK4
CDK9
CDKN1A
CDKN1B
CENPE
CFLAR
CKS1B
CUL1
CUL7
DDX19B
FBH1
FBXL2
FBXL20
FBXL3
FBXL4
FBXL5
FBXL8
FBXO15
FBXO16
FBXO17
FBXO2
FBXO25
FBXO27
FBXO3
FBXO32
FBXO34
FBXO4
FBXO43
FBXO44
FBXO48
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GHR
GLMN
GPS1
HSP90AA1
KCTD9
LAMTOR5
LMO2
MED21
MEOX2
MTUS1
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPARGC1A
PPP1CA
PTEN
RBX1
SEC23B
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UHRF2
10 interacting genes:
COMMD1
FBXW8
MEGF10
MTDH
MTNR1A
PLXNB3
RBX1
SKP1
TP53
UBE2M
Entrez ID
6500
9820
HPRD ID
03255
09901
Ensembl ID
ENSG00000113558
ENSG00000044090
Uniprot IDs
P63208
A0A669KBH4
Q14999
PDB IDs
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
3WSO
4I6J
5IBK
5JH5
5K35
5V4B
5VZT
5VZU
5XYL
6BVA
6BYH
6C16
6M90
6M91
6M92
6M93
6M94
6O60
6TTU
6VCD
6W66
6WCQ
6WNX
7B5L
7B5M
7B5R
7T1Y
7T1Z
7Z8B
7Z8T
7Z8V
7ZBW
7ZBZ
8BYA
8BYL
8CDJ
8CDK
8OR0
8OR3
8OR4
8S7D
8S7E
8UA6
8UBT
8UBU
9CB3
9JKB
9KBD
9KBF
2JNG
7Z8B
Enriched GO Terms of Interacting Partners
?
SCF Ubiquitin Ligase Complex
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
Proteolysis Involved In Protein Catabolic Process
Protein Catabolic Process
Post-translational Protein Modification
Macromolecule Catabolic Process
Protein Metabolic Process
Proteolysis
Protein Modification Process
Ubiquitin Ligase Complex
Ubiquitin-like Ligase-substrate Adaptor Activity
Macromolecule Metabolic Process
G1/S Transition Of Mitotic Cell Cycle
Cell Cycle G1/S Phase Transition
Catabolic Process
Regulation Of Cell Cycle
Ubiquitin Protein Ligase Binding
Cytosol
Ubiquitin-protein Transferase Activity
Cullin-RING Ubiquitin Ligase Complex
Cytoplasm
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Glycoprotein Catabolic Process
Regulation Of DNA Metabolic Process
Cul7-RING Ubiquitin Ligase Complex
Positive Regulation Of DNA Metabolic Process
Protein K48-linked Ubiquitination
Ubiquitin Protein Ligase Activity
Regulation Of Cell Cycle Process
Regulation Of Protein Stability
Regulation Of Protein Modification Process
Regulation Of Post-translational Protein Modification
Protein Binding
Regulation Of Protein Ubiquitination
Cellular Response To Stress
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Protein Catabolic Process
Regulation Of Protein Metabolic Process
TORC1 Signaling
Cul7-RING Ubiquitin Ligase Complex
Nucleotide-excision Repair
NEDD8 Transferase Activity
SCF Ubiquitin Ligase Complex
Negative Regulation Of Mitophagy
Regulation Of Proteolysis
Cul2-RING Ubiquitin Ligase Complex
Positive Regulation Of Epithelial Cell Apoptotic Process
Negative Regulation Of Proteolysis
Protein Neddylation
Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Cullin Family Protein Binding
Molecular Function Activator Activity
Regulation Of Ubiquitin-dependent Protein Catabolic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Proteasomal Protein Catabolic Process
Negative Regulation Of Macroautophagy
Copper Ion Binding
Regulation Of Mitophagy
DNA Damage Response, Signal Transduction By P53 Class Mediator
Negative Regulation Of Cellular Response To Insulin Stimulus
Negative Regulation Of Insulin Receptor Signaling Pathway
Regulation Of Autophagy Of Mitochondrion
Regulation Of Epithelial Cell Apoptotic Process
Protein Monoubiquitination
Protein Modification By Small Protein Conjugation
Mitophagy
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Helicase Activity
Negative Regulation Of G1 To G0 Transition
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cholesterol Import
Interferon-mediated Signaling Pathway
Regulation Of Insulin Receptor Signaling Pathway
Autophagy Of Mitochondrion
Regulation Of Neurogenesis
Post-translational Protein Modification
Apoptotic Process
Oligodendrocyte Apoptotic Process
Negative Regulation Of Pentose-phosphate Shunt
Cellular Response To UV
Negative Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Negative Regulation Of Catabolic Process
Regulation Of Autophagy
NEDD8 Conjugating Enzyme Activity
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Proteolysis Involved In Protein Catabolic Process
Regulation Of Cellular Response To Insulin Stimulus
Regulation Of Protein Catabolic Process
Insulin Receptor Signaling Pathway
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