SKP1 and PPARGC1A

Number of citations of the paper that reports this interaction (PubMedID 26407237)
41

Data Source:
BioGRID (enzymatic study)

		SKP1	PPARGC1A
Description		S-phase kinase associated protein 1	PPARG coactivator 1 alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex PcG Protein Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	Protein Binding Beta-catenin Binding Protein Domain Specific Binding Cullin Family Protein Binding Molecular Function Activator Activity Ubiquitin Ligase Complex Scaffold Activity F-box Domain Binding Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Nucleic Acid Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Protein Polyubiquitination Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of Protein Location In Nucleus Axon Development Protein K48-linked Ubiquitination Positive Regulation Of Epithelial Cell Apoptotic Process	Temperature Homeostasis Intracellular Glucose Homeostasis Response To Dietary Excess Gluconeogenesis Regulation Of DNA-templated Transcription Transcription Initiation At RNA Polymerase II Promoter MRNA Processing Mitochondrion Organization Digestion RNA Splicing Positive Regulation Of Gene Expression Response To Muscle Activity Fatty Acid Oxidation Respiratory Electron Transport Chain Developmental Process Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Homeostatic Process Response To Starvation Regulation Of Circadian Rhythm Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Rhythmic Process Negative Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Neuron Apoptotic Process Adipose Tissue Development Protein-containing Complex Assembly Energy Homeostasis Positive Regulation Of Cold-induced Thermogenesis
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of MITF-M dependent genes involved in metabolism Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		1-naphthaleneacetic acid (2S)-2-(1H-indol-3-yl)hexanoic acid (2S)-2-(1H-indol-3-yl)pentanoic acid (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid Indoleacetic acid
Diseases
GWAS		Mean platelet volume ( 32888494) Systemic lupus erythematosus ( 26502338 27399966)	Aspartate aminotransferase levels ( 33547301) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Essential tremor ( 27797806) Estimated glomerular filtration rate ( 31152163 31015462) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intralaminar thalamic nuclei volume ( 34006833) Lead levels ( 26025379) Molar-incisor hypomineralization ( 23918034) PR interval ( 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		75 interacting genes: ANKRD36BP1 APIP BTRC CACYBP CAND1 CCNA2 CDCA3 CDK4 CDK9 CDKN1A CDKN1B CENPE CFLAR CKS1B CUL1 CUL7 DDX19B FBH1 FBXL2 FBXL20 FBXL3 FBXL4 FBXL5 FBXL8 FBXO15 FBXO16 FBXO17 FBXO2 FBXO25 FBXO27 FBXO3 FBXO32 FBXO34 FBXO4 FBXO43 FBXO44 FBXO48 FBXO5 FBXO6 FBXO7 FBXO8 FBXO9 FBXW2 FBXW5 FBXW7 FBXW8 GHR GLMN GPS1 HSP90AA1 KCTD9 LAMTOR5 LMO2 MED21 MEOX2 MTUS1 MYC NFKBIA NFKBIB NFKBIE NUDT9P1 PPARGC1A PPP1CA PTEN RBX1 SEC23B SKP2 SUGT1 TBL1X TERF1 TRRAP TTC21A TTC9C UBE2D1 UHRF2	44 interacting genes: CAPNS1 CDK6 CREBBP ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NDN NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RARB RNF10 RXRA SIRT1 SKP1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF1 USF2
Entrez ID		6500	10891
HPRD ID		03255	05155
Ensembl ID		ENSG00000113558	ENSG00000109819
Uniprot IDs		P63208	D6RBF3 Q9UBK2
PDB IDs		1FQV 1FS1 1FS2 1LDK 1P22 2ASS 2AST 2E31 2E32 2OVP 2OVQ 2OVR 3L2O 3WSO 4I6J 5IBK 5JH5 5K35 5V4B 5VZT 5VZU 5XYL 6BVA 6BYH 6C16 6M90 6M91 6M92 6M93 6M94 6O60 6TTU 6VCD 6W66 6WCQ 6WNX 7B5L 7B5M 7B5R 7T1Y 7T1Z 7Z8B 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4 8S7D 8S7E 8UA6 8UBT 8UBU 9CB3 9JKB 9KBD 9KBF	1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ 5Z5S 5Z6S 6AD9 6FZF 6FZP 6IZM 6IZN 6K0T 6KXX 6KXY 6LN4 6MS7 6NWK 6NWL 6T1V 6W9K 6W9L 7E2E 7KHT 7PRV 7PRW 7PRX 8BF1 8DK4 9F7W 9F7X
Enriched GO Terms of Interacting Partners?		SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Protein Catabolic Process Post-translational Protein Modification Macromolecule Catabolic Process Protein Metabolic Process Proteolysis Protein Modification Process Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Catabolic Process Regulation Of Cell Cycle Ubiquitin Protein Ligase Binding Cytosol Ubiquitin-protein Transferase Activity Cullin-RING Ubiquitin Ligase Complex Cytoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Glycoprotein Catabolic Process Regulation Of DNA Metabolic Process Cul7-RING Ubiquitin Ligase Complex Positive Regulation Of DNA Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Process Regulation Of Protein Stability Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Binding Regulation Of Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process TORC1 Signaling	Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Hormone-mediated Signaling Pathway Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Negative Regulation Of Macromolecule Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Nuclear Steroid Receptor Activity DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intracellular Signal Transduction Rhythmic Process Estrogen Response Element Binding Transcription Coactivator Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Vitamin D Receptor Binding
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