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SKP1 and FBXO18
Number of citations of the paper that reports this interaction (PMID
11956208
)
25
Data Source:
HPRD
(in vivo)
SKP1
FBXO18
Gene Name
S-phase kinase-associated protein 1
F-box protein, helicase, 18
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Extracellular Vesicular Exosome
Nucleus
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
DNA Binding
ATP-dependent DNA Helicase Activity
Protein Binding
ATP Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Mitotic Cell Cycle
Notch Signaling Pathway
Circadian Rhythm
Viral Process
Protein Ubiquitination
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
DNA Catabolic Process, Endonucleolytic
Positive Regulation Of Protein Phosphorylation
DNA Duplex Unwinding
Response To Intra-S DNA Damage Checkpoint Signaling
Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by NOTCH1 HD Domain Mutants in Cancer
Hedgehog 'off' state
misspliced GSK3beta mutants stabilize beta-catenin
T41 mutants of beta-catenin aren't phosphorylated
truncated APC mutants destabilize the destruction complex
TCF7L2 mutants don't bind CTBP
Cyclin E associated events during G1/S transition
Signaling by Wnt
Regulation of PLK1 Activity at G2/M Transition
Downstream signaling events of B Cell Receptor (BCR)
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant
Degradation of beta-catenin by the destruction complex
G1/S Transition
AXIN mutants destabilize the destruction complex, activating WNT signaling
S33 mutants of beta-catenin aren't phosphorylated
Signaling by NOTCH1 in Cancer
Prolactin receptor signaling
Mitotic G1-G1/S phases
truncations of AMER1 destabilize the destruction complex
Signaling by NOTCH
Host Interactions of HIV factors
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex
AXIN missense mutants destabilize the destruction complex
S45 mutants of beta-catenin aren't phosphorylated
Regulation of APC/C activators between G1/S and early anaphase
S Phase
Signaling by ERBB4
APC/C-mediated degradation of cell cycle proteins
Signaling by Interleukins
SCF(Skp2)-mediated degradation of p27/p21
deletions in the AMER1 gene destabilize the destruction complex
AMER1 mutants destabilize the destruction complex
Signaling by NOTCH1 PEST Domain Mutants in Cancer
Interleukin-1 signaling
Cyclin A:Cdk2-associated events at S phase entry
SCF(Skp2)-mediated degradation of p27/p21
Mitotic G2-G2/M phases
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer
HIV Infection
APC truncation mutants have impaired AXIN binding
G2/M Transition
APC truncation mutants are not K63 polyubiquitinated
S37 mutants of beta-catenin aren't phosphorylated
Signaling by NOTCH1
Class I MHC mediated antigen processing & presentation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FBXW7 Mutants and NOTCH1 in Cancer
Vpu mediated degradation of CD4
G1 Phase
Cytokine Signaling in Immune system
Cell Cycle, Mitotic
NOTCH1 Intracellular Domain Regulates Transcription
Cyclin D associated events in G1
Nuclear signaling by ERBB4
Activation of NF-kappaB in B cells
SCF-beta-TrCP mediated degradation of Emi1
Regulation of mitotic cell cycle
Signaling by Hedgehog
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling
Degradation of GLI1 by the proteasome
Signaling by WNT in cancer
GLI3 is processed to GLI3R by the proteasome
Degradation of GLI2 by the proteasome
Drugs
Diseases
GWAS
Breast cancer (
20453838
)
Protein-Protein Interactions
67 interactors:
ANKRD36BP1
APIP
BTRC
CACYBP
CCNA2
CDCA3
CDK2
CDK4
CDK9
CDKN1B
CENPE
CKS1B
CTNNB1
CUL1
CUL7
DDX19B
FBXL2
FBXL3
FBXL4
FBXL5
FBXL6
FBXL8
FBXO11
FBXO15
FBXO16
FBXO17
FBXO18
FBXO2
FBXO25
FBXO28
FBXO3
FBXO32
FBXO34
FBXO4
FBXO44
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GLMN
GPS1
HSP90AA1
KCTD9
LMO2
MED21
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPP1CA
RBX1
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UBE2D3
UHRF2
8 interactors:
CUL1
PIM2
RAD51
RBX1
RPL13A
SKP1
UBC
ZDHHC17
Entrez ID
6500
84893
HPRD ID
03255
06243
Ensembl ID
ENSG00000134452
Uniprot IDs
P63208
B3KV95
Q2TAK1
Q8NFZ0
PDB IDs
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
4I6J
Enriched GO Terms of Interacting Partners
?
Protein Ubiquitination
Protein Modification By Small Protein Conjugation
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Protein Catabolic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Cellular Macromolecule Catabolic Process
Proteolysis
Cell Cycle
Cell Cycle Process
Cellular Protein Modification Process
Catabolic Process
Cellular Protein Metabolic Process
Regulation Of Cell Cycle
Mitotic Cell Cycle Process
Mitotic Cell Cycle
Protein Metabolic Process
Negative Regulation Of Cell Cycle
Regulation Of Cellular Protein Metabolic Process
Regulation Of Cell Cycle Process
Mitotic Cell Cycle Phase Transition
Regulation Of Protein Metabolic Process
Cell Cycle Phase Transition
Regulation Of Cell Cycle Phase Transition
Regulation Of Mitotic Cell Cycle
Positive Regulation Of Cellular Metabolic Process
Regulation Of Protein Ubiquitination
Cellular Metabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Protein Metabolic Process
G2/M Transition Of Mitotic Cell Cycle
Regulation Of Metabolic Process
Regulation Of Protein Catabolic Process
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Cellular Protein Metabolic Process
Positive Regulation Of Metabolic Process
Negative Regulation Of Mitotic Cell Cycle
Cell Division
Regulation Of Ubiquitin-protein Transferase Activity
G1/S Transition Of Mitotic Cell Cycle
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Mitotic Nuclear Division
Positive Regulation Of Protein Catabolic Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Ubiquitin-protein Transferase Activity
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Notch Signaling Pathway
G1/S Transition Of Mitotic Cell Cycle
Protein Monoubiquitination
Viral Process
Positive Regulation Of Ubiquitin-protein Ligase Activity Involved In Regulation Of Mitotic Cell Cycle Transition
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Proteasomal Protein Catabolic Process
Mitotic Cell Cycle Phase Transition
Cell Cycle Phase Transition
Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle
Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Ligase Activity
Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
Regulation Of Ubiquitin-protein Transferase Activity
Cellular Macromolecule Catabolic Process
Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process
G2/M Transition Of Mitotic Cell Cycle
Cell Cycle Process
Positive Regulation Of Protein Ubiquitination
Positive Regulation Of Proteolysis Involved In Cellular Protein Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Modification-dependent Protein Catabolic Process
Positive Regulation Of Cellular Protein Catabolic Process
Proteolysis Involved In Cellular Protein Catabolic Process
Cellular Protein Catabolic Process
Circadian Rhythm
Protein Ubiquitination
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Protein Catabolic Process
Protein Modification By Small Protein Conjugation
Cell Cycle
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Regulation Of Protein Ubiquitination
Positive Regulation Of Protein Catabolic Process
Mitotic Cell Cycle Process
Cellular Protein Metabolic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Mitotic Cell Cycle
Positive Regulation Of Proteolysis
Rhythmic Process
Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress
Cellular Protein Modification Process
Regulation Of DNA-templated Transcription In Response To Stress
Response To Stimulus
Regulation Of Protein Catabolic Process
Protein Metabolic Process
Negative Regulation Of Formation Of Translation Preinitiation Complex
Tagcloud
?
ankyrin
attenuates
bc
belonging
binds
box
collection
degenerate
elongation
elongin
hippel
inhibiting
initially
interacting
jak
lindau
motif
multifunctional
multiprotein
participates
pol
repeat
socs
spry
stat
suppressor
vhl
von
wd
Tagcloud (Difference)
?
ankyrin
attenuates
bc
belonging
binds
box
collection
degenerate
elongation
elongin
hippel
inhibiting
initially
interacting
jak
lindau
motif
multifunctional
multiprotein
participates
pol
repeat
socs
spry
stat
suppressor
vhl
von
wd
Tagcloud (Intersection)
?