SKP1 and FBXO32

Number of citations of the paper that reports this interaction (PubMedID 11717410)
42

Data Source:
HPRD (in vitro, in vivo)

		SKP1	FBXO32
Description		S-phase kinase associated protein 1	F-box protein 32
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex PcG Protein Complex	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Z Disc
	Molecular Function	Protein Binding Beta-catenin Binding Protein Domain Specific Binding Cullin Family Protein Binding Molecular Function Activator Activity Ubiquitin Ligase Complex Scaffold Activity F-box Domain Binding Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of Protein Location In Nucleus Axon Development Protein K48-linked Ubiquitination Positive Regulation Of Epithelial Cell Apoptotic Process	Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Cellular Response To Dexamethasone Stimulus
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins	Neddylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		1-naphthaleneacetic acid (2S)-2-(1H-indol-3-yl)hexanoic acid (2S)-2-(1H-indol-3-yl)pentanoic acid (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid Indoleacetic acid
Diseases
GWAS		Mean platelet volume ( 32888494) Systemic lupus erythematosus ( 26502338 27399966)	Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935 33627673) Intraocular pressure ( 29617998 29785010 30054594 31959993) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603)
Interacting Genes		75 interacting genes: ANKRD36BP1 APIP BTRC CACYBP CAND1 CCNA2 CDCA3 CDK4 CDK9 CDKN1A CDKN1B CENPE CFLAR CKS1B CUL1 CUL7 DDX19B FBH1 FBXL2 FBXL20 FBXL3 FBXL4 FBXL5 FBXL8 FBXO15 FBXO16 FBXO17 FBXO2 FBXO25 FBXO27 FBXO3 FBXO32 FBXO34 FBXO4 FBXO43 FBXO44 FBXO48 FBXO5 FBXO6 FBXO7 FBXO8 FBXO9 FBXW2 FBXW5 FBXW7 FBXW8 GHR GLMN GPS1 HSP90AA1 KCTD9 LAMTOR5 LMO2 MED21 MEOX2 MTUS1 MYC NFKBIA NFKBIB NFKBIE NUDT9P1 PPARGC1A PPP1CA PTEN RBX1 SEC23B SKP2 SUGT1 TBL1X TERF1 TRRAP TTC21A TTC9C UBE2D1 UHRF2	13 interacting genes: CDC34 CDK2 EIF3F KDM2A MLH1 MYC MYOD1 MYOG SH3GL1 SH3GL2 SH3GL3 SKP1 TTN
Entrez ID		6500	114907
HPRD ID		03255	05966
Ensembl ID		ENSG00000113558	ENSG00000156804
Uniprot IDs		P63208	I6L984 Q0VAQ6 Q498Y9 Q969P5
PDB IDs		1FQV 1FS1 1FS2 1LDK 1P22 2ASS 2AST 2E31 2E32 2OVP 2OVQ 2OVR 3L2O 3WSO 4I6J 5IBK 5JH5 5K35 5V4B 5VZT 5VZU 5XYL 6BVA 6BYH 6C16 6M90 6M91 6M92 6M93 6M94 6O60 6TTU 6VCD 6W66 6WCQ 6WNX 7B5L 7B5M 7B5R 7T1Y 7T1Z 7Z8B 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4 8S7D 8S7E 8UA6 8UBT 8UBU 9CB3 9JKB 9KBD 9KBF
Enriched GO Terms of Interacting Partners?		SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Protein Catabolic Process Post-translational Protein Modification Macromolecule Catabolic Process Protein Metabolic Process Proteolysis Protein Modification Process Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Catabolic Process Regulation Of Cell Cycle Ubiquitin Protein Ligase Binding Cytosol Ubiquitin-protein Transferase Activity Cullin-RING Ubiquitin Ligase Complex Cytoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Glycoprotein Catabolic Process Regulation Of DNA Metabolic Process Cul7-RING Ubiquitin Ligase Complex Positive Regulation Of DNA Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Process Regulation Of Protein Stability Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Binding Regulation Of Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process TORC1 Signaling	Myotube Differentiation Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle E-box Binding Striated Muscle Cell Differentiation Skeletal Muscle Cell Differentiation Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Skeletal Muscle Fiber Development Striated Muscle Cell Development Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Fate Commitment Muscle Cell Development Muscle Cell Differentiation Chromosome Organization Positive Regulation Of Striated Muscle Tissue Development Regulation Of Myoblast Fusion Positive Regulation Of Skeletal Muscle Tissue Development DNA-binding Transcription Activator Activity Regulation Of Skeletal Muscle Tissue Development Mitotic Cell Cycle Phase Transition Central Nervous System Development Skeletal Muscle Fiber Development Cell Cycle Phase Transition Cellular Response To Cytokine Stimulus Myotube Cell Development Protein Dimerization Activity Condensed Chromosome Cellular Response To Estradiol Stimulus Regulation Of Striated Muscle Tissue Development Detection Of Mechanical Stimulus Regulation Of Myotube Differentiation Regulation Of Muscle Organ Development Positive Regulation Of Myoblast Differentiation Positive Regulation Of Striated Muscle Cell Differentiation Response To Peptide Response To Cytokine Transcription Regulator Complex Male Germ Cell Nucleus Condensed Nuclear Chromosome Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Positive Regulation Of Metanephric Cap Mesenchymal Cell Proliferation Acinar Cell Proliferation Positive Regulation Of Acinar Cell Proliferation SCF Ubiquitin Ligase Complex Binding Presynapse Double-strand Break Repair Via Nonhomologous End Joining Euchromatin Identical Protein Binding Positive Regulation Of DNA Metabolic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?