SKP1 and LMO2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SKP1	LMO2
Description		S-phase kinase associated protein 1	LIM domain only 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol SCF Ubiquitin Ligase Complex Cul7-RING Ubiquitin Ligase Complex PcG Protein Complex	Nucleus Nucleoplasm Transcription Regulator Complex
	Molecular Function	Protein Binding Beta-catenin Binding Protein Domain Specific Binding Cullin Family Protein Binding Molecular Function Activator Activity Ubiquitin Ligase Complex Scaffold Activity F-box Domain Binding Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Activator Activity	Transcription Coregulator Binding Transcription Coactivator Activity Protein Binding Identical Protein Binding BHLH Transcription Factor Binding Metal Ion Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding DNA-binding Transcription Factor Binding
	Biological Process	Protein Polyubiquitination Chromatin Remodeling Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination Apoptotic Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Maintenance Of Protein Location In Nucleus Axon Development Protein K48-linked Ubiquitination Positive Regulation Of Epithelial Cell Apoptotic Process	Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of NF-kappaB in B cells Prolactin receptor signaling SCF-beta-TrCP mediated degradation of Emi1 Vpu mediated degradation of CD4 SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling NOTCH1 Intracellular Domain Regulates Transcription Regulation of PLK1 Activity at G2/M Transition Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling FCERI mediated NF-kB activation Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Orc1 removal from chromatin Cyclin D associated events in G1 Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Regulation of RUNX2 expression and activity Neddylation Interleukin-1 signaling Iron uptake and transport Negative regulation of NOTCH4 signaling Regulation of BACH1 activity Nuclear events stimulated by ALK signaling in cancer GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 Antigen processing: Ubiquitination & Proteasome degradation GSK3B-mediated proteasomal degradation of PD-L1(CD274) Degradation of CRY and PER proteins	RUNX1 regulates transcription of genes involved in differentiation of HSCs
Drugs		1-naphthaleneacetic acid (2S)-2-(1H-indol-3-yl)hexanoic acid (2S)-2-(1H-indol-3-yl)pentanoic acid (2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid Indoleacetic acid
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Mean platelet volume ( 32888494) Systemic lupus erythematosus ( 26502338 27399966)	Cognitive performance ( 19734545) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Major depressive disorder x sex interaction ( 34099189) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Red blood cell count ( 27863252 32888494)
Interacting Genes		75 interacting genes: ANKRD36BP1 APIP BTRC CACYBP CAND1 CCNA2 CDCA3 CDK4 CDK9 CDKN1A CDKN1B CENPE CFLAR CKS1B CUL1 CUL7 DDX19B FBH1 FBXL2 FBXL20 FBXL3 FBXL4 FBXL5 FBXL8 FBXO15 FBXO16 FBXO17 FBXO2 FBXO25 FBXO27 FBXO3 FBXO32 FBXO34 FBXO4 FBXO43 FBXO44 FBXO48 FBXO5 FBXO6 FBXO7 FBXO8 FBXO9 FBXW2 FBXW5 FBXW7 FBXW8 GHR GLMN GPS1 HSP90AA1 KCTD9 LAMTOR5 LMO2 MED21 MEOX2 MTUS1 MYC NFKBIA NFKBIB NFKBIE NUDT9P1 PPARGC1A PPP1CA PTEN RBX1 SEC23B SKP2 SUGT1 TBL1X TERF1 TRRAP TTC21A TTC9C UBE2D1 UHRF2	190 interacting genes: ABI2 ADAMTSL4 AFDN AGTRAP AIMP2 AIRIM ALDH6A1 ARHGEF5 ARID5A ARNT2 ATOSB AXIN1 BANP BCAS2 BEX2 BLZF1 BYSL C1orf94 CALCOCO2 CBY2 CCDC33 CDC25A CDC5L CDX4 CLHC1 CMTM5 CORO1A CORO1C DAZAP2 DBF4B DDIT3 DMRT3 DRAP1 DRC4 DSCAM DYDC1 EFHC1 EFHC2 EHMT2 EIF3B EIF4EBP1 ELF2 ENKD1 ERBIN FAAP20 FAM228A FAM90A1 FHL3 FHL5 GATA1 GATA2 GATA3 GFAP GMEB2 GOLGA2 GRB2 HDAC5 HNRNPC HNRNPM HOOK1 ICA1L IFT43 IHO1 IKZF1 IKZF3 INCA1 ISL1 ISY1 KANK2 KAZN KDM5A KIF2A KIF3B KLHL20 KPRP KRT15 KRT34 KRT40 KRT75 KRT80 KRTAP10-7 LDB1 LDB2 LDOC1 LMO4 LMOD3 LYL1 LZTS1 LZTS2 MAGEA8 MAPRE1 MAPRE2 MAPRE3 MBIP MISP MRFAP1L1 MSN MTUS2 MYOZ3 N4BP2L2 NCAPH2 NDOR1 NDUFAB1 NDUFB7 NFKBID NHLH1 NIF3L1 NOTCH2NLA NOXA1 NSMF NTAQ1 NUP62 NUTM1 PATZ1 PAX9 PBX4 PDE9A PHC2 POLR2G PRDM6 PRKG1 PSMA1 RBBP8 RCN1 REL RELA RINT1 RLIM ROCK1 RTL8C RUSC1 SAXO1 SAXO4 SGTB SKP1 SMAD2 SMUG1 SNAPC5 SOX5 SP1 SSX2IP STAT1 STAT3 STIP1 TAL1 TAL2 TBX2 TCP10L TEKT3 TFIP11 TFPT THAP6 TLE5 TLX3 TRIB3 TRIM23 TRIM54 TRIM55 TRIM63 TRIP6 TSC1 TSC22D4 TSEN15 TSEN54 TSGA10IP TSPYL2 TSSK3 TUFT1 UBA6 UBASH3B UBE2I USH1G VBP1 VEZF1 VMAC WASF1 WASHC1 YOD1 YPEL3 ZFP64 ZMYND12 ZNF185 ZNF19 ZNF24 ZNF250 ZNF34 ZNF410 ZNF641 ZNF655 ZNF688
Entrez ID		6500	4005
HPRD ID		03255	01586
Ensembl ID		ENSG00000113558	ENSG00000135363
Uniprot IDs		P63208	P25791
PDB IDs		1FQV 1FS1 1FS2 1LDK 1P22 2ASS 2AST 2E31 2E32 2OVP 2OVQ 2OVR 3L2O 3WSO 4I6J 5IBK 5JH5 5K35 5V4B 5VZT 5VZU 5XYL 6BVA 6BYH 6C16 6M90 6M91 6M92 6M93 6M94 6O60 6TTU 6VCD 6W66 6WCQ 6WNX 7B5L 7B5M 7B5R 7T1Y 7T1Z 7Z8B 7Z8T 7Z8V 7ZBW 7ZBZ 8BYA 8BYL 8CDJ 8CDK 8OR0 8OR3 8OR4 8S7D 8S7E 8UA6 8UBT 8UBU 9CB3 9JKB 9KBD 9KBF	2XJY 2XJZ 2YPA 4KFZ
Enriched GO Terms of Interacting Partners?		SCF Ubiquitin Ligase Complex SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Proteolysis Involved In Protein Catabolic Process Protein Catabolic Process Post-translational Protein Modification Macromolecule Catabolic Process Protein Metabolic Process Proteolysis Protein Modification Process Ubiquitin Ligase Complex Ubiquitin-like Ligase-substrate Adaptor Activity Macromolecule Metabolic Process G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Catabolic Process Regulation Of Cell Cycle Ubiquitin Protein Ligase Binding Cytosol Ubiquitin-protein Transferase Activity Cullin-RING Ubiquitin Ligase Complex Cytoplasm Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Glycoprotein Catabolic Process Regulation Of DNA Metabolic Process Cul7-RING Ubiquitin Ligase Complex Positive Regulation Of DNA Metabolic Process Protein K48-linked Ubiquitination Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Process Regulation Of Protein Stability Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Protein Binding Regulation Of Protein Ubiquitination Cellular Response To Stress Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Epithelial Cell Apoptotic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Protein Metabolic Process TORC1 Signaling	Protein Binding Nucleus Identical Protein Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Cytoskeleton Regulation Of RNA Metabolic Process Cytoskeleton Organization Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Primary Metabolic Process DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Transcription Regulator Complex Nucleoplasm Chromatin Sequence-specific DNA Binding Regulation Of Metabolic Process Mitotic Spindle Astral Microtubule End Cellular Developmental Process Microtubule DNA-binding Transcription Factor Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Negative Regulation Of Macromolecule Metabolic Process Cell Differentiation Cytoplasm Microtubule Cytoskeleton Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Spindle Assembly Microtubule-based Process Neuron Fate Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Erythrocyte Differentiation Microtubule Binding Developmental Process Transcription Cis-regulatory Region Binding Positive Regulation Of Erythrocyte Differentiation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?