MLST8 and RPS6KA3

Number of citations of the paper that reports this interaction (PubMedID 29236692)
59

Data Source:
BioGRID (enzymatic study)

		MLST8	RPS6KA3
Description		MTOR associated protein MLST8	ribosomal protein S6 kinase A3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Lysosome Lysosomal Membrane Cytosol Membrane TORC1 Complex TORC2 Complex Serine/threonine Protein Kinase Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Synapse
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Protein Serine/threonine Kinase Activator Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Kinase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	DNA Damage Response Cytoskeleton Organization Negative Regulation Of Autophagy Positive Regulation Of Cell Growth Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels TOR Signaling Positive Regulation Of TOR Signaling Regulation Of Actin Cytoskeleton Organization TORC1 Signaling TORC2 Signaling Negative Regulation Of Apoptotic Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Glycolytic Process Positive Regulation Of Lipid Biosynthetic Process Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Hypoxia Cellular Response To Osmotic Stress Positive Regulation Of Pentose-phosphate Shunt	Skeletal System Development Toll-like Receptor Signaling Pathway Signal Transduction Chemical Synaptic Transmission Central Nervous System Development Positive Regulation Of Cell Growth Response To Lipopolysaccharide Intracellular Signal Transduction TORC1 Signaling Negative Regulation Of Apoptotic Process Regulation Of Translation In Response To Stress Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II
Pathways		PIP3 activates AKT signaling Macroautophagy MTOR signalling mTORC1-mediated signalling HSF1-dependent transactivation Energy dependent regulation of mTOR by LKB1-AMPK CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of PTEN gene transcription Amino acids regulate mTORC1 High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs			Acetylsalicylic acid Fostamatinib
Diseases			Non-syndromic X-linked mental retardation Coffin-Lowry syndrome (CLS)
GWAS		Height ( 28552196)	Refractive error ( 32231278)
Interacting Genes		13 interacting genes: A2M APPL2 ATXN1 CDK1 CDK2 EIF4EBP1 KEAP1 LCOR MAPKAP1 MTOR PRMT1 RPS6KA3 RPTOR	44 interacting genes: ATM ATP5PF BAD BARX1 CREB1 CREBBP CTNND1 EIF3C ESR1 FBXO7 FGF2 FGFR3 FYN GRIN1 GRIN2D H2AX H3-4 H3C1 HMGN1 HMGN2 HTR2A ILKAP KRT18 MAGI1 MAPK1 MAPK3 MAPT MASP1 MLST8 MTOR NEDD4 NFKBIA NR4A1 PDPK1 PEA15 RPTOR SHANK1 SMS SRC STAT3 STK11 SUMO2 TP53 YBX1
Entrez ID		64223	6197
HPRD ID		17031	02092
Ensembl ID		ENSG00000167965	ENSG00000177189
Uniprot IDs		H3BPT1 Q9BVC4	A0A384MDW3 B1AXG1 B4DG22 B7ZB17 P51812
PDB IDs		4JSN 4JSP 4JSV 4JSX 4JT5 4JT6 5FLC 5H64 5WBU 5WBY 5ZCS 6BCU 6BCX 6SB0 6SB2 6ZWM 6ZWO 7OWG 7PE7 7PE8 7PE9 7PEA 7PEB 7PEC 7TZO 7UXC 7UXH 8ERA 8RCH 8RCK 9F44 9F45	4D9T 4D9U 4JG6 4JG7 4JG8 4NUS 4NW5 4NW6 5D9K 5D9L 7OPO 8EQ5 8R58 8XEY 8XFY
Enriched GO Terms of Interacting Partners?		TOR Signaling Negative Regulation Of Translational Initiation TORC1 Signaling Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Serine/threonine Protein Kinase Complex Positive Regulation Of Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Translational Initiation Cellular Response To Oxygen-containing Compound Cyclin-dependent Protein Kinase Activity Negative Regulation Of Metabolic Process Positive Regulation Of Pentose-phosphate Shunt Regulation Of Cell Differentiation Positive Regulation Of Cell Growth Negative Regulation Of Cellular Response To Insulin Stimulus Histone Kinase Activity TORC1 Complex Regulation Of Pentose-phosphate Shunt Cellular Response To Methionine Negative Regulation Of Translation Regulation Of Translation Intracellular Signal Transduction Response To Methionine Regulation Of NADP Metabolic Process Positive Regulation Of TORC1 Signaling TORC2 Complex Regulation Of Mitotic Cell Cycle Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Gene Expression G1/S Transition Of Mitotic Cell Cycle Regulation Of Multicellular Organismal Development Cellular Response To Amino Acid Stimulus Cell Cycle G1/S Phase Transition Cellular Response To Nutrient Levels Regulation Of Macromolecule Biosynthetic Process Cellular Response To L-leucine Positive Regulation Of TOR Signaling Cellular Response To Chemical Stress Regulation Of Primary Metabolic Process Regulation Of Protein Metabolic Process Regulation Of TORC1 Signaling Regulation Of Growth Post-transcriptional Regulation Of Gene Expression TORC2 Signaling Response To L-leucine Nucleoplasm Positive Regulation Of Transcription By RNA Polymerase III Enzyme-substrate Adaptor Activity	Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Signal Transduction Positive Regulation Of Signal Transduction Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Autophagy Regulation Of Carbohydrate Catabolic Process Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Developmental Process Regulation Of Pentose-phosphate Shunt Positive Regulation Of ATP Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Catabolic Process Regulation Of Purine Nucleotide Metabolic Process Intracellular Signaling Cassette Regulation Of NADP Metabolic Process Positive Regulation Of Glycolytic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Glycolytic Process DNA Damage Response Positive Regulation Of Phosphate Metabolic Process Anatomical Structure Morphogenesis Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Biological Quality Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Regulation Of Protein Stability Regulation Of Immune System Process Negative Regulation Of Signal Transduction Regulation Of ATP Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cellular Response To Heat Protein Localization To Organelle Regulation Of Cell Population Proliferation Positive Regulation Of Pentose-phosphate Shunt Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Primary Metabolic Process Response To Stress Regulation Of TOR Signaling Regulation Of Small Molecule Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process
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