MLST8 and PRMT1

Number of citations of the paper that reports this interaction (PMID 23455924)
3

Data Source:
BioGRID (two hybrid)

		MLST8	PRMT1
Gene Name		MTOR associated protein, LST8 homolog (S. cerevisiae)	protein arginine methyltransferase 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Methyltransferase Activity N-methyltransferase Activity Protein-arginine Omega-N Asymmetric Methyltransferase Activity Histone Methyltransferase Activity Identical Protein Binding Histone Methyltransferase Activity (H4-R3 Specific) Poly(A) RNA Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Actin Filament Polymerization T Cell Costimulation Positive Regulation Of TOR Signaling Regulation Of Rac GTPase Activity Regulation Of Actin Cytoskeleton Organization Cellular Response To Heat Fc-epsilon Receptor Signaling Pathway Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Cellular Response To Heat	Chromatin Organization Regulation Of Transcription, DNA-templated Protein Methylation Cell Surface Receptor Signaling Pathway Histone Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Neuron Projection Development Histone H4-R3 Methylation Negative Regulation Of Megakaryocyte Differentiation
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by FGFR in disease mTOR signalling Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation PI-3K cascade PKB-mediated events PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome CD28 co-stimulation CD28 dependent PI3K/Akt signaling Signaling by ERBB4 Role of LAT2/NTAL/LAB on calcium mobilization Constitutive PI3K/AKT Signaling in Cancer PI3K events in ERBB4 signaling S6K1-mediated signalling mTORC1-mediated signalling Signaling by ERBB2 Signaling by EGFR Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer PI3K/AKT Signaling in Cancer Adaptive Immune System Costimulation by the CD28 family IRS-mediated signalling PIP3 activates AKT signaling mTOR signalling S6K1-mediated signalling mTORC1-mediated signalling IGF1R signaling cascade VEGFA-VEGFR2 Pathway HSF1-dependent transactivation IRS-related events triggered by IGF1R PI3K events in ERBB2 signaling Release of eIF4E VEGFR2 mediated vascular permeability Downstream signaling of activated FGFR Signaling by Insulin receptor Innate Immune System Signalling by NGF Insulin receptor signalling cascade IRS-related events Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Cellular response to heat stress Release of eIF4E Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) PKB-mediated events PI3K Cascade	Chromatin modifying enzymes Chromatin organization RMTs methylate histone arginines
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: A2M AKT1S1 ATXN1 EIF4EBP1 MTOR PRMT1 PRR5L RPS6KB1 RPTOR	93 interactors: AR ARPC3 ASH2L AXIN1 BRCA1 BTG1 BTG2 C17orf53 C20orf196 C4orf17 CAPRIN1 CDC37 CEP162 CIRBP CNOT8 COIL DAXX DCAF16 DCAF8 DHX9 EIF4A1 ESR1 EWSR1 FAM83D FAM9A FBL FGF2 FLII FUS GPATCH2L GRHL3 GRIP1 HABP4 HIST1H3A HIST1H4A HIST2H4A HIST4H4 HNF4A HNRNPA1 HNRNPK HNRNPR HNRNPU HNRNPUL1 IDH3B IFNAR1 IGSF21 ILF3 KHDRBS1 KHDRBS2 KHDRBS3 LRIF1 MBP MECOM MED31 MLST8 NCOA1 NCOA2 NCOA3 NOL4 NRIP1 OFCC1 PIAS1 PPARA PRMT8 QKI RELA RNF187 RUNX1 S100A8 SAMD3 SPAG8 SPEG SPSB1 SPSB2 STAT1 STAT5A SUPT5H SYNCRIP TAF15 TBX6 TERF2 THRB TP53 VHL VPS72 WDFY3 WDR33 WDYHV1 YLPM1 YWHAG ZBTB14 ZMYM5 ZNF451
Entrez ID		64223	3276
HPRD ID		17031	04257
Ensembl ID		ENSG00000167965	ENSG00000126457
Uniprot IDs		Q9BVC4	B4DJ87 H7C2I1 Q99873
PDB IDs		4JSN 4JSP 4JSV 4JSX 4JT5 4JT6
Enriched GO Terms of Interacting Partners?		TOR Signaling Response To Heat Regulation Of Cellular Response To Heat Insulin Receptor Signaling Pathway Response To Temperature Stimulus Intracellular Signal Transduction Cellular Response To Insulin Stimulus Regulation Of Cellular Protein Metabolic Process Cellular Response To Heat Regulation Of Protein Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Signaling Response To Insulin Cell Communication Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Positive Regulation Of Transcription From RNA Polymerase III Promoter Enzyme Linked Receptor Protein Signaling Pathway Response To Amino Acid Regulation Of Signal Transduction Negative Regulation Of Cell Size Regulation Of Cell Size Response To Peptide Hormone Phosphatidylinositol-mediated Signaling Cellular Response To Organonitrogen Compound Regulation Of Signaling Response To Peptide Response To Abiotic Stimulus Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Cellular Metabolic Process Regulation Of Metabolic Process Cellular Response To Hormone Stimulus Signal Transduction Regulation Of Phosphorylation Response To Stimulus Regulation Of Phosphorus Metabolic Process Regulation Of Translation Negative Regulation Of Cellular Protein Metabolic Process Response To Organonitrogen Compound Regulation Of Cellular Component Size Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Regulation Of TOR Signaling Positive Regulation Of Endothelial Cell Proliferation Cellular Response To Stimulus Response To Hormone Cellular Response To Organic Substance Cell Surface Receptor Signaling Pathway Regulation Of Translational Initiation Positive Regulation Of Translation	Regulation Of Gene Expression Gene Expression Nucleobase-containing Compound Metabolic Process RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Cellular Metabolic Process Intracellular Receptor Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Positive Regulation Of Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Androgen Receptor Signaling Pathway Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Cellular Metabolic Process Biosynthetic Process Transcription From RNA Polymerase II Promoter Regulation Of Cellular Process MRNA Processing Chromatin Organization Cellular Process Chromatin Modification Response To Hormone MRNA Metabolic Process RNA Processing Chromosome Organization Cellular Response To Hormone Stimulus Metabolic Process Response To Organic Substance
Tagcloud ?		activates akt believed deactivated deregulates drosophila evaluates existence explained gbetal interacting ischemic lies msin1 mtor mtorc1 mtorc2 multiprotein pras40 protor raptor representing rictor s6k1 ser473 stream suppresses threonine tsc2	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Difference) ?		activates akt believed deactivated deregulates drosophila evaluates existence explained gbetal interacting ischemic lies msin1 mtor mtorc1 mtorc2 multiprotein pras40 protor raptor representing rictor s6k1 ser473 stream suppresses threonine tsc2	bbrd brucei clade clades connects dart dihydrolipoamide exemplified fmr homologues methyltransferases outgroup paralogue phylogeny prmt2 prmt3 prmt4 prmt5 prmt6 prmt7 prmt8 prmt9 prmts reconstructing resolve tbprmts tedious trypanosoma uncharacterized
Tagcloud (Intersection) ?