GM2A and PLD2

Number of citations of the paper that reports this interaction (PubMedID 11672434)
33

Data Source:
HPRD (in vitro)

		GM2A	PLD2
Description		ganglioside GM2 activator	phospholipase D2
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GO Annotations	Cellular Component	Extracellular Region Lysosome Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Brush Border Membrane Presynapse
	Molecular Function	Beta-N-acetylhexosaminidase Activity Lipid Transporter Activity Protein Binding Enzyme Activator Activity Phospholipase Activator Activity Hydrolase Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity	Catalytic Activity Phospholipase D Activity Protein Binding Hydrolase Activity Phosphatidylinositol Binding
	Biological Process	Ganglioside Metabolic Process Lipid Metabolic Process Sphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Glycosphingolipid Catabolic Process Nervous System Process Neuromuscular Process Controlling Balance	G Protein-coupled Receptor Internalization Lipid Metabolic Process Phosphatidic Acid Biosynthetic Process Receptor-mediated Endocytosis Cytoskeleton Organization Small GTPase-mediated Signal Transduction Phospholipid Catabolic Process Lipid Catabolic Process Intracellular Signal Transduction Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Vesicle-mediated Transport
Pathways		Neutrophil degranulation Glycosphingolipid catabolism	Synthesis of PG Synthesis of PA Role of phospholipids in phagocytosis RAC1 GTPase cycle RAC2 GTPase cycle
Drugs		Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid	Choline Choline salicylate
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)	Sphingolipid levels ( 22359512) Systemic lupus erythematosus ( 26502338)
Interacting Genes		4 interacting genes: GPLD1 HEXA LCOR PLD2	29 interacting genes: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A HIF1A LCK MTDH MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1 VHL
Entrez ID		2760	5338
HPRD ID		02034	03857
Ensembl ID		ENSG00000196743	ENSG00000129219
Uniprot IDs		P17900	O14939
PDB IDs		1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9	6OHM 6OHO 6OHP 6OHQ 6OHS 7SVP
Enriched GO Terms of Interacting Partners?		Phospholipase D Activity Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity Filopodium Tip Optic Nerve Morphogenesis Phosphate-containing Compound Metabolic Process Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Detection Of Temperature Stimulus Negative Regulation Of Skeletal Muscle Cell Proliferation Cell Migration In Hindbrain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Skeletal Muscle Cell Differentiation Axon Guidance Receptor Activity Negative Regulation Of Satellite Cell Differentiation Immunological Synapse Formation Detection Of Temperature Stimulus Involved In Sensory Perception Cranial Nerve Morphogenesis Hindbrain Tangential Cell Migration Dendritic Spine Development Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Retinal Ganglion Cell Axon Guidance Dendritic Spine Morphogenesis Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Activity Skeletal Muscle Satellite Cell Activation Lipid Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Sterol Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Phosphatase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Glycerophospholipid Metabolic Process Regulation Of Dephosphorylation Negative Regulation Of Triglyceride Catabolic Process Phospholipid Metabolic Process Response To Triglyceride Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Triglyceride Metabolic Process Hematopoietic Stem Cell Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Triglyceride Biosynthetic Process Cellular Response To Triglyceride Positive Regulation Of Dephosphorylation Immune Response-activating Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Clearance Activation Of Immune Response	Regulation Of Programmed Cell Death Regulation Of Apoptotic Process T Cell Costimulation Protein Tyrosine Kinase Activity Phospholipase Activator Activity Positive Regulation Of Immune System Process Cytosol Negative Regulation Of Apoptotic Process Non-membrane Spanning Protein Tyrosine Kinase Activity Negative Regulation Of Programmed Cell Death Positive Regulation Of Multicellular Organismal Process Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Phospholipase Binding Cell-cell Junction Regulation Of Developmental Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Glycolytic Process Plasma Membrane Regulation Of Transport Regulation Of Immune System Process Positive Regulation Of Signal Transduction Regulation Of Cell-cell Adhesion Regulation Of Multicellular Organismal Process Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Multicellular Organismal Development Positive Regulation Of T Cell Activation Cytoplasm Cellular Response To Oxygen Levels Regulation Of Cell Communication Regulation Of Signaling Enzyme Binding Cellular Response To Chemical Stress Fc-gamma Receptor Signaling Pathway Identical Protein Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of ATP Metabolic Process Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Cell Development Kinase Activity Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Peptide Hormone Protein Kinase Binding Regulation Of Cell Activation Positive Regulation Of Developmental Process Regulation Of Biological Quality
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