GM2A and PLD2

Number of citations of the paper that reports this interaction (PMID 11672434)
4

Data Source:
HPRD (in vitro)

		GM2A	PLD2
Gene Name		GM2 ganglioside activator	phospholipase D2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Hydrogen:potassium-exchanging ATPase Complex Cytoplasmic Side Of Plasma Membrane Lysosomal Lumen Apical Cortex Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Plasma Membrane Brush Border Membrane
	Molecular Function	Lipid Transporter Activity Phospholipase Activator Activity Beta-N-acetylgalactosaminidase Activity	Phospholipase D Activity Protein Binding Phosphatidylinositol Binding N-acylphosphatidylethanolamine-specific Phospholipase D Activity
	Biological Process	Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Small Molecule Metabolic Process Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity	G-protein Coupled Receptor Internalization Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidylglycerol Biosynthetic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Lipid Catabolic Process Synaptic Vesicle Recycling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Glycerophospholipid Biosynthetic Process
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism	Synthesis of PA Metabolism of lipids and lipoproteins Synthesis of PG Role of phospholipids in phagocytosis Phospholipid metabolism Glycerophospholipid biosynthesis Fcgamma receptor (FCGR) dependent phagocytosis Innate Immune System
Drugs		Platelet Activating Factor Lpc-Ether Glycerylphosphorylcholine MYRISTIC ACID
Diseases
GWAS		Bulimia nervosa ( 23568457)	Sphingolipid levels ( 22359512)
Protein-Protein Interactions		3 interactors: GPLD1 HEXA PLD2	26 interactors: ACTB ACTN1 ALDOA ALDOC AMPH AQP3 ARF1 BIN1 CAV1 CSK DPYSL2 EGFR FYN GAPDH GM2A LCK MTOR OPRM1 PEA15 PIP5K1A PLCG1 PRKCA PRKCD RPTOR SRC STXBP1
Entrez ID		2760	5338
HPRD ID		02034	03857
Ensembl ID		ENSG00000196743	ENSG00000129219
Uniprot IDs		P17900	I3L2C9 O14939
PDB IDs		1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?		Cellular Lipid Metabolic Process Glycolipid Metabolic Process GPI Anchor Release Cellular Response To Triglyceride Lipid Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Hematopoietic Stem Cell Migration To Bone Marrow Hematopoietic Stem Cell Migration Membrane Lipid Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytolysis Glycerophospholipid Metabolic Process Negative Regulation Of Triglyceride Catabolic Process Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Glycerolipid Metabolic Process Phospholipid Metabolic Process Response To Triglyceride Small Molecule Metabolic Process Immune Response-regulating Signaling Pathway Keratan Sulfate Catabolic Process G-protein Coupled Receptor Internalization Phosphatidylglycerol Biosynthetic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Hyaluronan Catabolic Process Chondroitin Sulfate Catabolic Process Transepithelial Transport Cellular Response To PH Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Alkaline Phosphatase Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Cholesterol Positive Regulation Of Immune Response Cellular Response To Sterol Regulation Of Triglyceride Biosynthetic Process Cell Migration Involved In Sprouting Angiogenesis Response To Cholesterol Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Lipid Catabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Keratan Sulfate Metabolic Process Positive Regulation Of Phosphatase Activity Regulation Of Immune Response Blood Vessel Endothelial Cell Migration Positive Regulation Of Immune System Process Positive Regulation Of Glucose Metabolic Process Regulation Of Triglyceride Metabolic Process Response To PH Synaptic Vesicle Recycling	Platelet Activation Blood Coagulation Regulation Of Body Fluid Levels Hemostasis Wound Healing Epidermal Growth Factor Receptor Signaling Pathway Response To Wounding ERBB Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Response To Stress Response To Organic Substance Endocytosis Cell Activation Vesicle-mediated Transport Enzyme Linked Receptor Protein Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Response To External Stimulus Neurotrophin Signaling Pathway Positive Regulation Of Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Immune System Process T Cell Costimulation Positive Regulation Of Intracellular Signal Transduction Innate Immune Response Response To Organonitrogen Compound Fc Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Immune System Process Protein Autophosphorylation Immune Response Regulation Of Cellular Localization Regulation Of Cell-cell Adhesion Defense Response Regulation Of Intracellular Signal Transduction Response To Growth Factor Immune System Process Regulation Of Signaling Positive Regulation Of Phosphorylation Negative Regulation Of Signaling Immune Response-activating Cell Surface Receptor Signaling Pathway Transport Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Catalytic Activity Cellular Response To Organonitrogen Compound Regulation Of Cell Activation
Tagcloud ?			1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld1 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Difference) ?			1alpha abolished believed blocks butanol catalyzes ectopic elevate explored generating glioma hif hydrolysis messenger overexpressed pa pc phosphatidic phosphatidylcholine phospholipase pld1 responsive se secretion tumorigenesis u87 utilize vegf
Tagcloud (Intersection) ?