GM2A and GPLD1

Number of citations of the paper that reports this interaction (PubMedID 10752311)
0

Data Source:
HPRD (in vitro)

		GM2A	GPLD1
Description		ganglioside GM2 activator	glycosylphosphatidylinositol specific phospholipase D1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Lysosome Cytosol Cytoplasmic Side Of Plasma Membrane Basolateral Plasma Membrane Apical Plasma Membrane Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Lysosomal Membrane Extracellular Matrix Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Beta-N-acetylhexosaminidase Activity Lipid Transporter Activity Protein Binding Enzyme Activator Activity Phospholipase Activator Activity Hydrolase Activity Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity	Glycosylphosphatidylinositol Phospholipase D Activity Phospholipase D Activity Hydrolase Activity Sodium Channel Regulator Activity
	Biological Process	Ganglioside Metabolic Process Lipid Metabolic Process Sphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Glycosphingolipid Catabolic Process Nervous System Process Neuromuscular Process Controlling Balance	Ossification Cell Migration Involved In Sprouting Angiogenesis Chondrocyte Differentiation Complement Receptor Mediated Signaling Pathway Lipid Metabolic Process Negative Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Protein Secretion Response To Glucose Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Alkaline Phosphatase Activity Positive Regulation Of Triglyceride Biosynthetic Process Negative Regulation Of Triglyceride Catabolic Process Positive Regulation Of Glucose Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Cellular Response To Insulin Stimulus Hematopoietic Stem Cell Migration Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Apoptotic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Transepithelial Transport Cellular Response To Cholesterol Cellular Response To Triglyceride Cellular Response To Xenobiotic Stimulus Cellular Response To PH Hematopoietic Stem Cell Migration To Bone Marrow Regulation Of Cellular Response To Insulin Stimulus
Pathways		Neutrophil degranulation Glycosphingolipid catabolism	Post-translational modification: synthesis of GPI-anchored proteins
Drugs		Platelet Activating Factor Lauric acid Lpc-Ether Choline alfoscerate Myristic acid
Diseases		GM2 gangliosidoses, including: Tay-Sachs disease (type I); Sandhoff disease (type II); Tay-Sachs disease AB variant
GWAS		Bulimia nervosa ( 23568457) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Serum folate levels ( 29953918)	Hematological and biochemical traits ( 20139978) Liver enzyme levels ( 18940312) Liver enzyme levels (alkaline phosphatase) ( 22001757) Serum alkaline phosphatase levels ( 29403010 31666285 33339817 33547301)
Interacting Genes		4 interacting genes: GPLD1 HEXA LCOR PLD2	5 interacting genes: ALPP APOA1 APOA4 CD55 GM2A
Entrez ID		2760	2822
HPRD ID		02034	03946
Ensembl ID		ENSG00000196743	ENSG00000112293
Uniprot IDs		P17900	P80108
PDB IDs		1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9
Enriched GO Terms of Interacting Partners?		Phospholipase D Activity Positive Regulation Of Alkaline Phosphatase Activity Glycosylphosphatidylinositol Phospholipase D Activity Filopodium Tip Optic Nerve Morphogenesis Phosphate-containing Compound Metabolic Process Regulation Of Skeletal Muscle Cell Proliferation Transmembrane-ephrin Receptor Activity Negative Regulation Of Skeletal Muscle Cell Differentiation Detection Of Temperature Stimulus Negative Regulation Of Skeletal Muscle Cell Proliferation Cell Migration In Hindbrain Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Regulation Of Skeletal Muscle Cell Differentiation Axon Guidance Receptor Activity Negative Regulation Of Satellite Cell Differentiation Immunological Synapse Formation Detection Of Temperature Stimulus Involved In Sensory Perception Cranial Nerve Morphogenesis Hindbrain Tangential Cell Migration Dendritic Spine Development Negative Regulation Of Skeletal Muscle Satellite Cell Proliferation Retinal Ganglion Cell Axon Guidance Dendritic Spine Morphogenesis Regulation Of Skeletal Muscle Satellite Cell Proliferation Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Ephrin Receptor Activity Skeletal Muscle Satellite Cell Activation Lipid Metabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Sterol Positive Regulation Of Triglyceride Metabolic Process Positive Regulation Of Phosphatase Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Triglyceride Biosynthetic Process Glycerophospholipid Metabolic Process Regulation Of Dephosphorylation Negative Regulation Of Triglyceride Catabolic Process Phospholipid Metabolic Process Response To Triglyceride Immune Response-regulating Cell Surface Receptor Signaling Pathway Negative Regulation Of Triglyceride Metabolic Process Hematopoietic Stem Cell Migration Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Triglyceride Biosynthetic Process Cellular Response To Triglyceride Positive Regulation Of Dephosphorylation Immune Response-activating Signaling Pathway Positive Regulation Of High-density Lipoprotein Particle Clearance Activation Of Immune Response	Lipid Transporter Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity Regulation Of Intestinal Cholesterol Absorption Chylomicron Regulation Of Intestinal Lipid Absorption Phospholipid Efflux Regulation Of Intestinal Absorption Low-density Lipoprotein Particle Reverse Cholesterol Transport Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Cholesterol Transfer Activity Protein-lipid Complex Assembly Cholesterol Efflux Lipoprotein Metabolic Process Lipid Storage Plasma Lipoprotein Particle Remodeling Protein-containing Complex Remodeling Acylglycerol Homeostasis Lipid Transport Lipid Binding Phosphatidylcholine Metabolic Process Regulation Of Cholesterol Transport Cholesterol Transport Sterol Transport Phospholipid Transport Extracellular Vesicle Sterol Homeostasis Cholesterol Homeostasis Sphingolipid Activator Protein Activity Beta-N-acetylgalactosaminidase Activity Cholesterol Metabolic Process Cell Surface Side Of Membrane Phospholipid Binding Sterol Metabolic Process Blood Microparticle Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Lipid Metabolic Process Organophosphate Ester Transport Regulation Of Lipid Transport Peptidyl-methionine Modification Positive Regulation Of Small Molecule Metabolic Process High-density Lipoprotein Particle Receptor Binding Organic Hydroxy Compound Transport Chylomicron Assembly Negative Regulation Of Plasma Lipoprotein Oxidation Response To Lipid Hydroperoxide
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