GM2A and HEXA

Number of citations of the paper that reports this interaction (PMID 9217013)
1

Data Source:
HPRD (in vitro)

		GM2A	HEXA
Gene Name		GM2 ganglioside activator	hexosaminidase A (alpha polypeptide)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Hydrogen:potassium-exchanging ATPase Complex Cytoplasmic Side Of Plasma Membrane Lysosomal Lumen Apical Cortex Extracellular Vesicular Exosome	Membrane Lysosomal Lumen Extracellular Vesicular Exosome
	Molecular Function	Lipid Transporter Activity Phospholipase Activator Activity Beta-N-acetylgalactosaminidase Activity	Beta-N-acetylhexosaminidase Activity Protein Heterodimerization Activity
	Biological Process	Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Ganglioside Catabolic Process Lipid Transport Learning Or Memory Oligosaccharide Catabolic Process Lipid Storage Small Molecule Metabolic Process Neuromuscular Process Controlling Balance Positive Regulation Of Hydrolase Activity	Carbohydrate Metabolic Process Sphingolipid Metabolic Process Glycosphingolipid Metabolic Process Pathogenesis Glycosaminoglycan Metabolic Process Chondroitin Sulfate Metabolic Process Chondroitin Sulfate Catabolic Process Hyaluronan Metabolic Process Hyaluronan Catabolic Process Keratan Sulfate Metabolic Process Keratan Sulfate Catabolic Process Small Molecule Metabolic Process
Pathways		Sphingolipid metabolism Metabolism of lipids and lipoproteins Glycosphingolipid metabolism	MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Metabolism of lipids and lipoproteins Defective B4GALT7 causes EDS, progeroid type Keratan sulfate/keratin metabolism MPS I - Hurler syndrome MPS IX - Natowicz syndrome Chondroitin sulfate/dermatan sulfate metabolism Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism CS/DS degradation Hyaluronan uptake and degradation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Hyaluronan metabolism Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D Glycogen storage diseases MPS IIIC - Sanfilippo syndrome C Sphingolipid metabolism Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Keratan sulfate degradation Glycosphingolipid metabolism Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective CHST3 causes SEDCJD Defective B3GAT3 causes JDSSDHD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS MPS VII - Sly syndrome Metabolism of carbohydrates MPS VI - Maroteaux-Lamy syndrome
Drugs		Platelet Activating Factor Lpc-Ether Glycerylphosphorylcholine MYRISTIC ACID
Diseases
GWAS		Bulimia nervosa ( 23568457)
Protein-Protein Interactions		3 interactors: GPLD1 HEXA PLD2	2 interactors: GM2A USP22
Entrez ID		2760	3073
HPRD ID		02034	06040
Ensembl ID		ENSG00000196743	ENSG00000213614
Uniprot IDs		P17900	H3BP20 P06865
PDB IDs		1G13 1PU5 1PUB 1TJJ 2AF9 2AG2 2AG4 2AG9	1QBC 2GJX 2GK1
Enriched GO Terms of Interacting Partners?		Cellular Lipid Metabolic Process Glycolipid Metabolic Process GPI Anchor Release Cellular Response To Triglyceride Lipid Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Clearance Hematopoietic Stem Cell Migration To Bone Marrow Hematopoietic Stem Cell Migration Membrane Lipid Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Cytolysis Glycerophospholipid Metabolic Process Negative Regulation Of Triglyceride Catabolic Process Complement Receptor Mediated Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Glycerolipid Metabolic Process Phospholipid Metabolic Process Response To Triglyceride Small Molecule Metabolic Process Immune Response-regulating Signaling Pathway Keratan Sulfate Catabolic Process G-protein Coupled Receptor Internalization Phosphatidylglycerol Biosynthetic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Hyaluronan Catabolic Process Chondroitin Sulfate Catabolic Process Transepithelial Transport Cellular Response To PH Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Alkaline Phosphatase Activity Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Cholesterol Positive Regulation Of Immune Response Cellular Response To Sterol Regulation Of Triglyceride Biosynthetic Process Cell Migration Involved In Sprouting Angiogenesis Response To Cholesterol Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Negative Regulation Of Lipid Catabolic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Keratan Sulfate Metabolic Process Positive Regulation Of Phosphatase Activity Regulation Of Immune Response Blood Vessel Endothelial Cell Migration Positive Regulation Of Immune System Process Positive Regulation Of Glucose Metabolic Process Regulation Of Triglyceride Metabolic Process Response To PH Synaptic Vesicle Recycling	Ganglioside Catabolic Process Oligosaccharide Catabolic Process Ganglioside Metabolic Process Glycosphingolipid Catabolic Process Glycolipid Catabolic Process Histone Deubiquitination Ceramide Catabolic Process Sphingolipid Catabolic Process Membrane Lipid Catabolic Process Histone Ubiquitination Lipid Storage Oligosaccharide Metabolic Process Histone H4 Acetylation
Tagcloud ?			alanine associate carboxy catalysis derivatized eluted glu70 heterodimeric histidine hxxehx76h inserted inserting lys215 mpp mutagenesis nickel peptidase plasmon polypeptide positions presequences proper residue resin ser114 ser314 stochiometry surrounding tagged
Tagcloud (Difference) ?			alanine associate carboxy catalysis derivatized eluted glu70 heterodimeric histidine hxxehx76h inserted inserting lys215 mpp mutagenesis nickel peptidase plasmon polypeptide positions presequences proper residue resin ser114 ser314 stochiometry surrounding tagged
Tagcloud (Intersection) ?