MERTK and LMO4

Number of citations of the paper that reports this interaction (PMID 15231748)
65

Data Source:
HPRD (two hybrid)

		MERTK	LMO4
Gene Name		MER proto-oncogene, tyrosine kinase	LIM domain only 4
Image
Gene Ontology Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Rhabdomere	Transcription Factor Complex
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Enhancer Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Factor Binding Zinc Ion Binding
	Biological Process	Natural Killer Cell Differentiation Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Cell-cell Signaling Spermatogenesis Blood Coagulation Peptidyl-tyrosine Phosphorylation Platelet Activation Secretion By Cell Substrate Adhesion-dependent Cell Spreading Apoptotic Cell Clearance Protein Kinase B Signaling Positive Regulation Of Phagocytosis Leukocyte Migration Negative Regulation Of Lymphocyte Activation Retina Development In Camera-type Eye Vagina Development	Neural Tube Closure Ventricular Septum Development Transcription From RNA Polymerase II Promoter Ventral Spinal Cord Interneuron Differentiation Spinal Cord Motor Neuron Differentiation Spinal Cord Association Neuron Differentiation Negative Regulation Of Protein Complex Assembly Regulation Of Cell Fate Specification Positive Regulation Of Transcription From RNA Polymerase II Promoter Thymus Development Regulation Of Cell Activation
Pathways		Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 21833088)	Response to TNF antagonist treatment ( 18615156) White blood cell types ( 21738478)
Protein-Protein Interactions		8 interactors: BMPR2 GAS6 GRB2 IKBKG LMO4 NEDD4L TNK2 VAV1	53 interactors: AES AMOT AMOTL2 BANP BRCA1 CALCOCO2 CCDC102B CEP170P1 CSNK2B DDB1 DEAF1 ERCC6L GABPB1 GADD45A GOLGA2 GRHL2 GSK3B ITSN1 KANK2 KIAA1958 KIF3B KPNA1 KRT15 KRT31 KRT40 LDB1 LDB2 MERTK MTA1 NFYC NHLH1 NONO PDE4DIP PITPNB PLK1 PPARG RBBP8 RBPMS RPS6KA6 SEC24D SMAD4 SMAD9 TCF21 TCF4 TFIP11 TINAGL1 TNFSF11 TP53BP2 TSEN15 VPS52 ZBTB43 ZNF397 ZNF675
Entrez ID		10461	8543
HPRD ID		05269	09122
Ensembl ID		ENSG00000153208	ENSG00000143013
Uniprot IDs		E9PHX8 Q12866	P61968
PDB IDs		2DBJ 2P0C 3BPR 3BRB 3TCP	2L4Z
Enriched GO Terms of Interacting Partners?		Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Regulation Of Systemic Arterial Blood Pressure Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Cellular Component Organization Response To Stress Regulation Of Cell Activation Immune System Process Positive Regulation Of Protein Metabolic Process Viral Process Regulation Of Blood Pressure Negative Regulation Of Systemic Arterial Blood Pressure Cellular Response To Growth Factor Stimulus Immune Response Regulation Of Phosphorylation Regulation Of Endocytosis Response To Growth Factor Platelet Activation Endocytosis Positive Regulation Of Cellular Metabolic Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Leukocyte Migration Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Protein Phosphorylation Regulation Of Signal Transduction Phagocytosis Fc Receptor Signaling Pathway Innate Immune Response Immune Response-activating Cell Surface Receptor Signaling Pathway Cell Migration Regulation Of Metabolic Process Positive Regulation Of Cell Activation Positive Regulation Of Phosphorylation Regulation Of Signaling Negative Regulation Of Blood Pressure Regulation Of Nitrogen Compound Metabolic Process Blood Circulation Response To External Stimulus Positive Regulation Of Immune System Process Cell Motility Positive Regulation Of Protein Modification Process Signal Transduction Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Vesicle-mediated Transport Regulation Of Lymphocyte Activation Regulation Of Protein Phosphorylation Negative Regulation Of Signal Transduction Signaling	Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated RNA Biosynthetic Process Nucleobase-containing Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Regulation Of Nitrogen Compound Metabolic Process Tissue Development Negative Regulation Of Nucleic Acid-templated Transcription Cellular Nitrogen Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Multicellular Organismal Development Developmental Process Gene Expression Regulation Of Binding Regulation Of Gene Expression Anatomical Structure Development Cellular Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Epithelium Development Negative Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Embryo Development Positive Regulation Of Cellular Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Gene Expression Positive Regulation Of Nucleocytoplasmic Transport Embryo Development Ending In Birth Or Egg Hatching Regulation Of Signal Transduction Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Metabolic Process Biosynthetic Process Regulation Of DNA Methylation Cell Cycle Somatic Stem Cell Maintenance Regulation Of Protein Binding Anatomical Structure Morphogenesis
Tagcloud ?		apoptotic autoimmunity c1q clearance dehydrogenases e8 ebpbeta efferocytosis engulfed enhancement enhancing glucocorticoid glucocorticoids lxr lxrs macrophages mfg partly phagocytic phagocytosis ppardelta raldh1 raralpha retinaldehyde retinoids rxralpha seem sensing ucp2	arrays attenuated cisplatin cochlea cochlear collectively custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Difference) ?		apoptotic autoimmunity c1q clearance dehydrogenases e8 ebpbeta efferocytosis engulfed enhancement enhancing glucocorticoid glucocorticoids lxr lxrs macrophages mfg partly phagocytic phagocytosis ppardelta raldh1 raralpha retinaldehyde retinoids rxralpha seem sensing ucp2	arrays attenuated cisplatin cochlea cochlear collectively custom downstream esr1 facilitates immunoblots insights interactomes jak1 machinery mediating modulating modulation nitration otoprotective ototoxicity partners pivotal player relaying stat stat3 trolox wistar
Tagcloud (Intersection) ?