MERTK

Description		MER proto-oncogene, tyrosine kinase
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Membrane Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity
	Biological Process	Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Spermatogenesis Nervous System Development Cell Migration Platelet Activation Secretion By Cell Substrate Adhesion-dependent Cell Spreading Apoptotic Cell Clearance Lymphocyte Activation Positive Regulation Of Phagocytosis Negative Regulation Of Lymphocyte Activation Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Retina Development In Camera-type Eye Vagina Development Neutrophil Clearance Negative Regulation Of Leukocyte Apoptotic Process
Pathways		Cell surface interactions at the vascular wall
Drugs		2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol Fostamatinib
Diseases		Retinitis pigmentosa (RP)
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Alanine aminotransferase levels ( 34315874 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Cluster headache ( 34184781) Coronary artery disease ( 33020668 29212778) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 21833088 31604244) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure ( 30224653)
Interacting Genes		11 interacting genes: BMPR2 DSCAM ERBB2 GAS6 GRB2 IKBKG LCOR LMO4 NEDD4L TNK2 VAV1
Entrez ID		10461
HPRD ID		05269
Ensembl ID		ENSG00000153208
Uniprot IDs		Q12866
PDB IDs		2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA 5K0K 5K0X 5TC0 5TD2 5U6C 6MEP 7AAX 7AAY 7AAZ 7AB0 7AB1 7AB2 7AVX 7AVY 7AVZ 7AW0 7AW1 7AW2 7AW3 7AW4 7CQE 7DXL 7M5Z 7OAM 7OLS 7OLV 7OLX 7XHY 9BHI 9BHJ 9BHK
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphorylation Grb2-EGFR Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Endocytosis Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Growth Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Activation Regulation Of Axon Extension Involved In Axon Guidance Cellular Developmental Process Schwann Cell Development Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Chemotaxis Intracellular Signaling Cassette Motor Neuron Axon Guidance Positive Regulation Of Developmental Growth Neuron Projection Development Regulation Of Metabolic Process Epidermal Growth Factor Receptor Binding Regulation Of Lymphocyte Activation Neuromuscular Junction Development Positive Regulation Of Axon Extension Regulation Of Chemotaxis Natural Killer Cell Mediated Cytotoxicity Protein Tyrosine Kinase Binding Growth Factor Binding Neuron Projection Guidance Axon Guidance Positive Regulation Of Protein Phosphorylation Natural Killer Cell Mediated Immunity T Cell Costimulation Positive Regulation Of Cellular Component Organization Regulation Of Growth Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Synapse Organization Regulation Of Kinase Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity
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