MERTK and GAS6

Number of citations of the paper that reports this interaction (PubMedID 8939948)
0

Data Source:
HPRD (in vitro)

		MERTK	GAS6
Description		MER proto-oncogene, tyrosine kinase	growth arrest specific 6
Image
GO Annotations	Cellular Component	Photoreceptor Outer Segment Extracellular Space Cytoplasm Plasma Membrane Membrane Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Platelet Alpha Granule Lumen Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity	Phosphatidylserine Binding Signaling Receptor Binding Calcium Ion Binding Protein Binding Protein-macromolecule Adaptor Activity Receptor Tyrosine Kinase Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Receptor Ligand Activity
	Biological Process	Natural Killer Cell Differentiation Negative Regulation Of Cytokine Production Protein Phosphorylation Phagocytosis Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell-cell Signaling Spermatogenesis Nervous System Development Cell Migration Platelet Activation Secretion By Cell Substrate Adhesion-dependent Cell Spreading Apoptotic Cell Clearance Lymphocyte Activation Positive Regulation Of Phagocytosis Negative Regulation Of Lymphocyte Activation Establishment Of Localization In Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Retina Development In Camera-type Eye Vagina Development Neutrophil Clearance Negative Regulation Of Leukocyte Apoptotic Process	Neuron Migration Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway Positive Regulation Of Glomerular Filtration Protein Phosphorylation Phagocytosis Apoptotic Process Signal Transduction Cell Surface Receptor Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Blood Coagulation Cellular Response To Starvation Positive Regulation Of Gene Expression Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Cell Migration Fusion Of Virus Membrane With Host Plasma Membrane Viral Genome Replication Cell Differentiation Animal Organ Regeneration Cell-substrate Adhesion Cellular Response To Nutrient Levels Positive Regulation Of TOR Signaling Activation Of Protein Kinase B Activity Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Differentiation Myeloid Cell Apoptotic Process Negative Regulation Of Myeloid Cell Apoptotic Process Cellular Response To Interferon-alpha B Cell Chemotaxis Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Fibroblast Apoptotic Process Positive Regulation Of Protein Kinase Activity Negative Regulation Of DNA-templated Transcription Symbiont Entry Into Host Cell Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phagocytosis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Biomineral Tissue Development Positive Regulation Of ERK1 And ERK2 Cascade Calcium Ion Transmembrane Transport Cellular Response To Vitamin K Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus Protein Localization To Plasma Membrane Extracellular Matrix Assembly Dendritic Cell Differentiation Hematopoietic Stem Cell Migration To Bone Marrow Negative Regulation Of Oligodendrocyte Apoptotic Process Negative Regulation Of Fibroblast Apoptotic Process Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Dendritic Cell Chemotaxis Negative Regulation Of Renal Albumin Absorption Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Cell surface interactions at the vascular wall	Platelet degranulation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Cell surface interactions at the vascular wall Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol Fostamatinib
Diseases		Retinitis pigmentosa (RP)
GWAS		Acute anterior uveitis in ankylosing spondylitis ( 32492107) Alanine aminotransferase levels ( 34315874 33547301) Appendicular lean mass ( 33097823) Aspartate aminotransferase levels ( 34315874 33547301) Cluster headache ( 34184781) Coronary artery disease ( 33020668 29212778) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Hepatitis C induced liver fibrosis ( 22841784) Multiple sclerosis ( 21833088 31604244) Myocardial infarction ( 33532862) Neutrophil percentage of white cells ( 32888494) Systolic blood pressure ( 30224653)	Anorectal malformation ( 31136621) Apolipoprotein B levels ( 32203549) Aspartate aminotransferase levels ( 33547301) Glycated hemoglobin levels ( 34059833 28898252) Hematocrit ( 32888494) Hemoglobin ( 32888494) LDL cholesterol ( 30275531) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte count ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 27863252) Serum alkaline phosphatase levels ( 33547301) Total cholesterol levels ( 29083408) Triglyceride levels ( 32154731 32203549) Triglycerides ( 27036123 30275531)
Interacting Genes		11 interacting genes: BMPR2 DSCAM ERBB2 GAS6 GRB2 IKBKG LCOR LMO4 NEDD4L TNK2 VAV1	3 interacting genes: AXL MERTK TYRO3
Entrez ID		10461	2621
HPRD ID		05269	02705
Ensembl ID		ENSG00000153208	ENSG00000183087
Uniprot IDs		Q12866	B4DZY7 Q14393
PDB IDs		2DBJ 2P0C 3BPR 3BRB 3TCP 4M3Q 4MH7 4MHA 5K0K 5K0X 5TC0 5TD2 5U6C 6MEP 7AAX 7AAY 7AAZ 7AB0 7AB1 7AB2 7AVX 7AVY 7AVZ 7AW0 7AW1 7AW2 7AW3 7AW4 7CQE 7DXL 7M5Z 7OAM 7OLS 7OLV 7OLX 7XHY 9BHI 9BHJ 9BHK	1H30 2C5D 4RA0 5VXZ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Phosphorylation Grb2-EGFR Complex Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Cell Growth Cell Surface Receptor Signaling Pathway Regulation Of Phosphorylation Endocytosis Positive Regulation Of Axon Extension Involved In Axon Guidance Positive Regulation Of Growth Cell Differentiation Regulation Of Phosphorus Metabolic Process Regulation Of Cellular Component Organization Positive Regulation Of Metabolic Process Import Into Cell Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Cell Activation Regulation Of Axon Extension Involved In Axon Guidance Cellular Developmental Process Schwann Cell Development Regulation Of Cell Growth Positive Regulation Of Protein Metabolic Process Positive Regulation Of Kinase Activity Positive Regulation Of Chemotaxis Intracellular Signaling Cassette Motor Neuron Axon Guidance Positive Regulation Of Developmental Growth Neuron Projection Development Regulation Of Metabolic Process Epidermal Growth Factor Receptor Binding Regulation Of Lymphocyte Activation Neuromuscular Junction Development Positive Regulation Of Axon Extension Regulation Of Chemotaxis Natural Killer Cell Mediated Cytotoxicity Protein Tyrosine Kinase Binding Growth Factor Binding Neuron Projection Guidance Axon Guidance Positive Regulation Of Protein Phosphorylation Natural Killer Cell Mediated Immunity T Cell Costimulation Positive Regulation Of Cellular Component Organization Regulation Of Growth Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Vesicle-mediated Transport Synapse Organization Regulation Of Kinase Activity Regulation Of Natural Killer Cell Mediated Cytotoxicity	Vagina Development Female Genitalia Development Natural Killer Cell Differentiation Apoptotic Cell Clearance Genitalia Development Substrate Adhesion-dependent Cell Spreading Transmembrane Receptor Protein Tyrosine Kinase Activity Natural Killer Cell Activation Platelet Activation Phagocytosis Neutrophil Clearance Protein Tyrosine Kinase Activity Cell-substrate Adhesion Negative Regulation Of Lymphocyte Activation Receptor Complex Reproductive Structure Development Negative Regulation Of Leukocyte Activation Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Activation Ovulation Cycle Lymphocyte Differentiation Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Viral Life Cycle Mononuclear Cell Differentiation Leukocyte Differentiation Secretion By Cell Endocytosis Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Lymphocyte Activation Male Gamete Generation Spermatogenesis Forebrain Cell Migration Protein Kinase Activity Secretion Regulation Of Lymphocyte Activation Negative Regulation Of Immune System Process Gamete Generation Negative Regulation Of Leukocyte Apoptotic Process Leukocyte Activation Nervous System Development Positive Regulation Of Viral Process Import Into Cell Kinase Activity Regulation Of Cell Activation Enzyme-linked Receptor Protein Signaling Pathway Cell Activation Virus Receptor Activity Regulation Of Viral Life Cycle Cell Adhesion Neuron Apoptotic Process
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