SMARCD1 and NR1H4

Number of citations of the paper that reports this interaction (PubMedID 12917342)
49

Data Source:
BioGRID (pull down)

		SMARCD1	NR1H4
Description		SWI/SNF related BAF chromatin remodeling complex subunit D1	nuclear receptor subfamily 1 group H member 4
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GO Annotations	Cellular Component	Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Brahma Complex NpBAF Complex NBAF Complex GBAF Complex	Chromatin Euchromatin Nucleus Nucleoplasm Cytosol Nuclear Speck Receptor Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Molecular Adaptor Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coregulator Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Nuclear Receptor Binding Bile Acid Binding Bile Acid Nuclear Receptor Activity Sequence-specific DNA Binding Metal Ion Binding Nuclear Retinoid X Receptor Binding Chenodeoxycholic Acid Binding
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Cellular Response To Fatty Acid Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Intracellular Glucose Homeostasis Immune System Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Cell-cell Junction Assembly Notch Signaling Pathway Bile Acid Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Regulation Of Low-density Lipoprotein Particle Clearance Bile Acid And Bile Salt Transport Cell Differentiation Intracellular Receptor Signaling Pathway Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-17 Production Toll-like Receptor 9 Signaling Pathway Regulation Of Urea Metabolic Process Intracellular Triglyceride Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Nuclear Receptor-mediated Bile Acid Signaling Pathway Glucose Homeostasis Cholesterol Homeostasis Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Inflammatory Response Fatty Acid Homeostasis Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Triglyceride Homeostasis Regulation Of Bile Acid Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Fatty Acid Negative Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Cholesterol Metabolic Process Cellular Response To Bile Acid Positive Regulation Of Adipose Tissue Development Positive Regulation Of Phosphatidic Acid Biosynthetic Process Positive Regulation Of Glutamate Metabolic Process Positive Regulation Of Ammonia Assimilation Cycle
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols
Drugs			alpha-Linolenic acid Ursodeoxycholic acid Farnesol Fexaramine Cholic Acid Deoxycholic acid Taurocholic acid Arachidonic Acid Obeticholic acid Chenodeoxycholic acid (8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid Myrrh Nidufexor Tropifexor
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Low density lipoprotein cholesterol levels ( 29403010) Squamous cell carcinoma ( 23341777)
Interacting Genes		156 interacting genes: ABI1 ABI2 ABI3 ACTMAP ADAT2 AIRIM ANKRD23 ANKRD49 ANKS1A ANP32B APOA5 AR ARMC10 ARRDC3 BCAS2 BEND5 BEX3 BLOC1S5 BRWD1 C4BPA CALCOCO2 CCDC102B CCDC197 CCDC33 CCDC85B CDC5L CDR2 CDSN CDX2 CEACAM6 CFTR CHFR CHN2 CLNK COG6 COL1A2 CORO1A CUEDC1 CYSRT1 DCTN2 DISC1 EGFL7 EIF4G1 ESR1 ESS2 FAM136A FAM161A FBXO7 FEZ1 FOS FUS GATA1 GCC1 GIGYF1 GINS3 GOLGA6L9 GPRASP3 GRAMD4 HES6 HNRNPC HOMEZ HOXD3 HSF2BP HSPB1 IGKC IKBIP IKZF3 INSC IQCB1 JUN KATNBL1 KDM1A KEAP1 KIAA0753 KLF1 KMT5B KRT15 KRT16 KRT18 KRT27 KRT31 KRT34 KRT37 KRT38 KRT75 LDB2 LDOC1 LZTS2 MAGEA2 MAGEA2B MAGEA6 MED4 MKRN3 MTNR1B MTUS2 NAB2 NECAB2 NELFA NME1 NONO NR1H4 NR3C1 NUCB2 NUDT16L1 NUTM1 OGT PACSIN3 PAICS PBX4 PCBD1 PGR PICK1 PIH1D1 PKNOX2 PLAGL2 PPM1J PRDX1 PRMT6 PSTPIP1 RIF1 RORB RPS29 SCARA5 SCHIP1 SCNM1 SERTAD3 SHISA6 SMUG1 SNF8 SPSB2 STH STMN3 SYCE1L TCP10L THOC7 TLE5 TNIP2 TP53 TRIM27 TRIM54 TRIM72 USHBP1 USP54 VPS37B WASHC1 YJU2B YWHAG ZC2HC1C ZMAT5 ZMYND12 ZNF417 ZNF438 ZNF511 ZNF629 ZNF655 ZNF69	15 interacting genes: CASP8 EP300 ESR1 GAPDH GRIN1 H3C1 NCOA1 NCOA6 NCOR2 PPARGC1A RXRA RXRG SIRT1 SMARCD1 SMARCD3
Entrez ID		6602	9971
HPRD ID		03438	04827
Ensembl ID		ENSG00000066117	ENSG00000012504
Uniprot IDs		Q96GM5	B6ZGS9 F1DAL1 Q96RI1
PDB IDs		6LTH 6LTJ 7VDV 7Y8R	1OSH 3BEJ 3DCT 3DCU 3FLI 3FXV 3GD2 3HC5 3HC6 3L1B 3OKH 3OKI 3OLF 3OMK 3OMM 3OOF 3OOK 3P88 3P89 3RUT 3RUU 3RVF 4OIV 4QE8 4WVD 5IAW 5ICK 5Q0I 5Q0J 5Q0K 5Q0L 5Q0M 5Q0N 5Q0O 5Q0P 5Q0Q 5Q0R 5Q0S 5Q0T 5Q0U 5Q0V 5Q0W 5Q0X 5Q0Y 5Q0Z 5Q10 5Q11 5Q12 5Q13 5Q14 5Q15 5Q16 5Q17 5Q18 5Q19 5Q1A 5Q1B 5Q1C 5Q1D 5Q1E 5Q1F 5Q1G 5Q1H 5Q1I 5WZX 5Y1J 5Y44 5Y49 5YXB 5YXD 5YXJ 5YXL 5Z12 6A5W 6A5X 6A5Y 6A5Z 6A60 6HL0 6HL1 6ITM 7D42 7TRB 7VUE 8HBM 8HD3
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Nucleus Intermediate Filament Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Estrogen Response Element Binding Supramolecular Fiber Organization Cytoskeleton Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity DNA-binding Transcription Factor Activity Intermediate Filament Regulation Of Actin Nucleation Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Structural Molecule Activity Actin-based Cell Projection Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of MiRNA Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Steroid Binding SCAR Complex Positive Regulation Of MiRNA Transcription Cornified Envelope Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Protein Kinase C Inhibitor Activity Cytoskeleton Organization	Nuclear Receptor Binding Positive Regulation Of Macromolecule Biosynthetic Process Chromatin Transcription Coactivator Activity Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Transcription Coregulator Binding Regulation Of Primary Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Transcription By RNA Polymerase II Rhythmic Process Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex Positive Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Nuclear Retinoid X Receptor Binding Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Remodeling Nuclear Steroid Receptor Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Nuclear Receptor-mediated Signaling Pathway Developmental Process Myeloid Cell Differentiation Response To Estradiol Regulation Of RNA Metabolic Process Nucleus Regulation Of Androgen Receptor Signaling Pathway Positive Regulation Of Multicellular Organismal Process Glucose Metabolic Process Chromatin Organization Transcription Coregulator Activity Nuclear Estrogen Receptor Binding Nucleobase-containing Compound Biosynthetic Process Regulation Of Multicellular Organismal Process Nervous System Development Cell Differentiation Hormone-mediated Signaling Pathway Regulation Of Thyroid Hormone Receptor Signaling Pathway Hexose Metabolic Process
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