SMARCD1 and ABI2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SMARCD1	ABI2
Description		SWI/SNF related BAF chromatin remodeling complex subunit D1	abl interactor 2
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GO Annotations	Cellular Component	Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Brahma Complex NpBAF Complex NBAF Complex GBAF Complex	Nucleus Cytoplasm Cytosol Cytoskeleton Actin Filament Adherens Junction Lamellipodium Filopodium SCAR Complex Filopodium Tip Cell Projection Dendritic Spine Anchoring Junction Actin-based Cell Projection
	Molecular Function	Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Molecular Adaptor Activity	Protein Binding Cytoskeletal Anchor Activity SH3 Domain Binding Kinase Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Cellular Response To Fatty Acid Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Mitophagy Neuron Migration Cytoskeleton Organization Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Zonula Adherens Assembly Cell Projection Morphogenesis Regulation Of Dendritic Spine Morphogenesis Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs RAC1 GTPase cycle RAC2 GTPase cycle RAC3 GTPase cycle FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Butyrylcholinesterase levels ( 21862451) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subclinical atherosclerosis traits (other) ( 17903303) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Trunk fat mass ( 28552196) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		156 interacting genes: ABI1 ABI2 ABI3 ACTMAP ADAT2 AIRIM ANKRD23 ANKRD49 ANKS1A ANP32B APOA5 AR ARMC10 ARRDC3 BCAS2 BEND5 BEX3 BLOC1S5 BRWD1 C4BPA CALCOCO2 CCDC102B CCDC197 CCDC33 CCDC85B CDC5L CDR2 CDSN CDX2 CEACAM6 CFTR CHFR CHN2 CLNK COG6 COL1A2 CORO1A CUEDC1 CYSRT1 DCTN2 DISC1 EGFL7 EIF4G1 ESR1 ESS2 FAM136A FAM161A FBXO7 FEZ1 FOS FUS GATA1 GCC1 GIGYF1 GINS3 GOLGA6L9 GPRASP3 GRAMD4 HES6 HNRNPC HOMEZ HOXD3 HSF2BP HSPB1 IGKC IKBIP IKZF3 INSC IQCB1 JUN KATNBL1 KDM1A KEAP1 KIAA0753 KLF1 KMT5B KRT15 KRT16 KRT18 KRT27 KRT31 KRT34 KRT37 KRT38 KRT75 LDB2 LDOC1 LZTS2 MAGEA2 MAGEA2B MAGEA6 MED4 MKRN3 MTNR1B MTUS2 NAB2 NECAB2 NELFA NME1 NONO NR1H4 NR3C1 NUCB2 NUDT16L1 NUTM1 OGT PACSIN3 PAICS PBX4 PCBD1 PGR PICK1 PIH1D1 PKNOX2 PLAGL2 PPM1J PRDX1 PRMT6 PSTPIP1 RIF1 RORB RPS29 SCARA5 SCHIP1 SCNM1 SERTAD3 SHISA6 SMUG1 SNF8 SPSB2 STH STMN3 SYCE1L TCP10L THOC7 TLE5 TNIP2 TP53 TRIM27 TRIM54 TRIM72 USHBP1 USP54 VPS37B WASHC1 YJU2B YWHAG ZC2HC1C ZMAT5 ZMYND12 ZNF417 ZNF438 ZNF511 ZNF629 ZNF655 ZNF69	194 interacting genes: ABI3 ABL1 ABLIM3 ACTMAP ADAM19 AIRIM AKAP8L AKAP9 ANKRD55 ANKS1A ARHGAP32 ARMC7 ATOSB ATP23 BAG4 BIN3 BLOC1S5 BLOC1S6 BORCS6 C1orf216 C20orf202 C4orf17 CCDC102B CCDC57 CCDC74B CCHCR1 CDK6 CENPH CENPQ CEP44 CEP57 CIMIP2B CLPP COG3 CRX CUEDC1 DCTN2 DISC1 DLGAP2 DLGAP4 DNAI7 DTNB EFS EGLN3 EGR4 EIF3H ENAH ENKD1 FAM161B FAM90A1 FAM9C FBXL19 FHL5 FKBP1A FOXD4L1 GAS2L2 GCC1 GFAP GGN GPANK1 HGS HHEX HNRNPK HOMER3 HSF2BP IFT20 IHO1 INCA1 INO80B INSYN1 KHDRBS1 KIAA1217 KIFC3 KNSTRN KRT13 KRT14 KRT15 KRT19 KRT20 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT75 LENG1 LGALS9B LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LNX1 LURAP1 LZTS2 MAGEA1 MCM7 MED10 MED11 MED29 MEOX2 MRFAP1 MRFAP1L1 MRPL28 MRPL44 MYO15B MYOG MYOZ3 NCK1 NCK2 NCKIPSD NFASC NME4 NUP62 OGT OIP5 OOEP PAK2 PCM1 PDLIM7 PFDN5 PHETA1 PHF1 PIN1 PLEKHN1 POMC PPIF PPP3CA PRAM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA1 PWWP2B RABEP1 RABGEF1 RASD1 RNPS1 RPP25 RSPH14 RUSC1 SDCBP SH3BP1 SH3KBP1 SHANK3 SLA SMARCB1 SMARCD1 SNAP23 SNAP91 SNAPIN SNX18 SNX7 SORBS3 STAM2 STX19 STX4 TFIP11 TLE5 TPM2 TRAF3IP1 TRIM32 TRIM72 TRIML2 TRIP6 UBQLN2 USHBP1 USP2 VARS2 VASP VCL VMA22 VPS28 VPS37C WASF2 WASF3 WASHC1 WASHC3 WASL WIPF1 WWOX ZFP90 ZMYND12 ZNF474 ZNF688
Entrez ID		6602	10152
HPRD ID		03438	07338
Ensembl ID		ENSG00000066117	ENSG00000138443
Uniprot IDs		Q96GM5	A0A0C4DG21 A0A7D9NKC8 B7Z836 E9PEZ7 F8WAL6 Q9NYB9
PDB IDs		6LTH 6LTJ 7VDV 7Y8R	2ED0 3P8C 4N78 7USC 7USD 7USE
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Nucleus Intermediate Filament Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Estrogen Response Element Binding Supramolecular Fiber Organization Cytoskeleton Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity DNA-binding Transcription Factor Activity Intermediate Filament Regulation Of Actin Nucleation Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Structural Molecule Activity Actin-based Cell Projection Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of MiRNA Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Steroid Binding SCAR Complex Positive Regulation Of MiRNA Transcription Cornified Envelope Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Protein Kinase C Inhibitor Activity Cytoskeleton Organization	Protein Binding Supramolecular Fiber Organization Organelle Organization Cytoskeleton Cytoskeleton Organization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Keratin Filament Intermediate Filament Actin Filament Organization SH3 Domain Binding Cytoskeletal Anchor Activity Plasma Membrane Bounded Cell Projection Assembly Structural Molecule Activity Cell Projection Assembly Plasma Membrane Bounded Cell Projection Organization Cellular Component Assembly Cell Projection Organization Lamellipodium Assembly Epithelial Cell Differentiation Actin Polymerization Or Depolymerization Regulation Of Organelle Organization Positive Regulation Of Organelle Organization Postsynaptic Density Regulation Of Supramolecular Fiber Organization Regulation Of Actin Filament Organization Regulation Of Cytoskeleton Organization Lamellipodium Organization Intermediate Filament Cytoskeleton Actin Cytoskeleton Glutamatergic Synapse Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Translational Initiation Regulation Of Cellular Component Organization Cytoplasm Microtubule-based Process Positive Regulation Of Cytoskeleton Organization Vesicle Organization Positive Regulation Of Cellular Component Biogenesis Protein Localization To Vacuole Intracellular Protein Localization Morphogenesis Of An Epithelium Actin Binding Microvesicle Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Localization To Organelle Positive Regulation Of RNA Biosynthetic Process
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