SMARCD1 and CDX2

Number of citations of the paper that reports this interaction (PubMedID 19371634)
0

Data Source:
BioGRID (pull down)

		SMARCD1	CDX2
Description		SWI/SNF related BAF chromatin remodeling complex subunit D1	caudal type homeobox 2
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GO Annotations	Cellular Component	Kinetochore Chromatin Nucleus Nucleoplasm Nuclear Matrix SWI/SNF Complex RSC-type Complex Brahma Complex NpBAF Complex NBAF Complex GBAF Complex	Chromatin Condensed Nuclear Chromosome Nucleus Nucleoplasm Transcription Repressor Complex Protein-containing Complex
	Molecular Function	Chromatin Binding Transcription Coregulator Activity Transcription Coactivator Activity Signaling Receptor Binding Protein Binding Molecular Adaptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Methyl-CpG Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Chromatin Organization Nucleosome Disassembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Nervous System Development Positive Regulation Of Cell Population Proliferation Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of T Cell Differentiation Negative Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Myoblast Differentiation Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of DNA-templated Transcription Regulation Of G0 To G1 Transition Cellular Response To Fatty Acid Positive Regulation Of Stem Cell Population Maintenance Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Double-strand Break Repair Regulation Of Nucleotide-excision Repair	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Blastocyst Development Trophectodermal Cell Differentiation Placenta Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Pattern Specification Process Positive Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Embryonic Pattern Specification Animal Organ Morphogenesis Anterior/posterior Axis Specification Anterior/posterior Pattern Specification Regulation Of Somitogenesis Cell Differentiation Somatic Stem Cell Population Maintenance Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Cell Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Stem Cell Differentiation Intestinal Epithelial Cell Differentiation Labyrinthine Layer Development
Pathways		RMTs methylate histone arginines RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of MITF-M-dependent genes involved in pigmentation Regulation of MITF-M-dependent genes involved in pigmentation Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Formation of the canonical BAF (cBAF) complex Formation of the polybromo-BAF (pBAF) complex Formation of the embryonic stem cell BAF (esBAF) complex Formation of the non-canonical BAF (ncBAF) complex Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF) Formation of neuronal progenitor and neuronal BAF (npBAF and nBAF)	Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634)	Body mass index ( 26426971) Monocyte count ( 27863252) Pancreatic cancer ( 25086665)
Interacting Genes		156 interacting genes: ABI1 ABI2 ABI3 ACTMAP ADAT2 AIRIM ANKRD23 ANKRD49 ANKS1A ANP32B APOA5 AR ARMC10 ARRDC3 BCAS2 BEND5 BEX3 BLOC1S5 BRWD1 C4BPA CALCOCO2 CCDC102B CCDC197 CCDC33 CCDC85B CDC5L CDR2 CDSN CDX2 CEACAM6 CFTR CHFR CHN2 CLNK COG6 COL1A2 CORO1A CUEDC1 CYSRT1 DCTN2 DISC1 EGFL7 EIF4G1 ESR1 ESS2 FAM136A FAM161A FBXO7 FEZ1 FOS FUS GATA1 GCC1 GIGYF1 GINS3 GOLGA6L9 GPRASP3 GRAMD4 HES6 HNRNPC HOMEZ HOXD3 HSF2BP HSPB1 IGKC IKBIP IKZF3 INSC IQCB1 JUN KATNBL1 KDM1A KEAP1 KIAA0753 KLF1 KMT5B KRT15 KRT16 KRT18 KRT27 KRT31 KRT34 KRT37 KRT38 KRT75 LDB2 LDOC1 LZTS2 MAGEA2 MAGEA2B MAGEA6 MED4 MKRN3 MTNR1B MTUS2 NAB2 NECAB2 NELFA NME1 NONO NR1H4 NR3C1 NUCB2 NUDT16L1 NUTM1 OGT PACSIN3 PAICS PBX4 PCBD1 PGR PICK1 PIH1D1 PKNOX2 PLAGL2 PPM1J PRDX1 PRMT6 PSTPIP1 RIF1 RORB RPS29 SCARA5 SCHIP1 SCNM1 SERTAD3 SHISA6 SMUG1 SNF8 SPSB2 STH STMN3 SYCE1L TCP10L THOC7 TLE5 TNIP2 TP53 TRIM27 TRIM54 TRIM72 USHBP1 USP54 VPS37B WASHC1 YJU2B YWHAG ZC2HC1C ZMAT5 ZMYND12 ZNF417 ZNF438 ZNF511 ZNF629 ZNF655 ZNF69	18 interacting genes: ACAT2 ATM CDK2 CFAP206 CREBBP DNMT3L EP300 GSK3B HNF1A KRTAP4-12 MAPK1 MAPK14 MRE11 PAX6 SMARCA4 SMARCB1 SMARCD1 UBB
Entrez ID		6602	1045
HPRD ID		03438	02622
Ensembl ID		ENSG00000066117	ENSG00000165556
Uniprot IDs		Q96GM5	Q99626
PDB IDs		6LTH 6LTJ 7VDV 7Y8R	5LTY 6ES2 6ES3 7Q4N
Enriched GO Terms of Interacting Partners?		Protein Binding Identical Protein Binding Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Nucleus Intermediate Filament Organization Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Estrogen Response Element Binding Supramolecular Fiber Organization Cytoskeleton Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity DNA-binding Transcription Factor Activity Intermediate Filament Regulation Of Actin Nucleation Regulation Of Nucleobase-containing Compound Metabolic Process Developmental Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Structural Molecule Activity Actin-based Cell Projection Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Metabolic Process Regulation Of MiRNA Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Transcription Coactivator Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Steroid Binding SCAR Complex Positive Regulation Of MiRNA Transcription Cornified Envelope Regulation Of MiRNA Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Protein Kinase C Inhibitor Activity Cytoskeleton Organization	Chromatin Remodeling Positive Regulation Of DNA Metabolic Process Positive Regulation Of Double-strand Break Repair Regulation Of Cellular Response To Heat Regulation Of Cellular Response To Stress Chromatin Organization Positive Regulation Of Macromolecule Metabolic Process Regulation Of Chromosome Organization Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA Repair Regulation Of Double-strand Break Repair P53 Binding Regulation Of DNA Metabolic Process Positive Regulation Of Metabolic Process Regulation Of DNA Repair Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Myoblast Differentiation Regulation Of Cell Cycle Phase Transition Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of RNA Metabolic Process Positive Regulation Of Gene Expression, Epigenetic NpBAF Complex Regulation Of Mitotic Cell Cycle RSC-type Complex NBAF Complex Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of RNA Biosynthetic Process Meiosis I Cell Cycle Process Positive Regulation Of Macromolecule Biosynthetic Process Host-mediated Activation Of Viral Transcription Regulation Of Organelle Organization Histone H3K27 Acetyltransferase Activity Regulation Of Myoblast Differentiation Nucleosome Disassembly Positive Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Protein-DNA Complex Disassembly Regulation Of Primary Metabolic Process Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of RNA Metabolic Process DNA Damage Checkpoint Signaling Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Peptide Lactyltransferase (CoA-dependent) Activity Positive Regulation Of Glucose Mediated Signaling Pathway
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