EEA1 and RAB5B

Number of citations of the paper that reports this interaction (PubMedID 12493736)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		EEA1	RAB5B
Description		early endosome antigen 1	RAB5B, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Cytoplasmic Vesicle Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynaptic Endosome Postsynaptic Early Endosome Glutamatergic Synapse	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Synaptic Vesicle Membrane Early Endosome Membrane Melanosome Extracellular Exosome
	Molecular Function	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Metal Ion Binding
	Biological Process	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Chemical Synaptic Transmission, Postsynaptic	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Endosomal Transport Antigen Processing And Presentation Regulation Of Endocytosis Plasma Membrane To Endosome Transport
Pathways		Toll Like Receptor 9 (TLR9) Cascade	Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry
Drugs		Inositol 1,3-Bisphosphate
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 30566500 22885925) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Interacting Genes		15 interacting genes: CDC73 IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 USP7 ZFYVE16	19 interacting genes: APOA5 CDK1 CHM EEA1 FHIP1B GLP1R HUNK PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SNCA SUN2 TBC1D15 TBC1D17 TFRC
Entrez ID		8411	5869
HPRD ID		05460	01544
Ensembl ID		ENSG00000102189	ENSG00000111540
Uniprot IDs		Q15075	P61020
PDB IDs		1HYI 1HYJ 1JOC 3MJH	2HEI
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Early Endosome Early Endosome Membrane Intracellular Protein Transport Vesicle Organization Endomembrane System Endosomal Transport Protein Transport Endosome GDP Binding Intracellular Transport Phagocytic Vesicle Establishment Of Protein Localization Plasma Membrane To Endosome Transport Cellular Localization Establishment Of Localization In Cell Membrane Fusion GTPase Activity Intracellular Protein Localization GTP Binding Transcytosis Endosome Organization Endocytosis Vesicle Fusion Organelle Membrane Fusion Regulation Of Vesicle-mediated Transport Organelle Fusion Synaptic Vesicle Membrane Regulation Of Cellular Component Organization Organelle Organization Import Into Cell Vesicle Docking Endocytic Vesicle G Protein Activity Nucleotide Binding Organelle Localization By Membrane Tethering Phagocytic Vesicle Membrane Membrane Docking Melanosome Endosome Membrane Regulation Of Vesicle Size Regulation Of Endocytosis Membrane Organization Regulation Of Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Clearance Positive Regulation Of Protein-containing Complex Disassembly SNAP Receptor Activity Golgi Apparatus SNARE Complex	Vesicle-mediated Transport GTPase Activator Activity Endocytosis Import Into Cell Response To Copper Ion Small GTPase Binding Hsp70 Protein Binding Regulation Of Endocytosis Endocytic Vesicle Endosome Establishment Of Localization In Cell Endosomal Transport Regulation Of Cilium Assembly Intracellular Transport Regulation Of Vesicle-mediated Transport Early Endosome To Late Endosome Transport Regulation Of Receptor-mediated Endocytosis Intracellular Signal Transduction Early Endosome Recycling Endosome Response To Iron Ion Regulation Of Cellular Component Organization Pronuclear Fusion Cellular Localization Glucagon-like Peptide 1 Receptor Activity Ribonucleotide Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mast Cell Chemotaxis Regulation Of Transport
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