EEA1 and RRAD

Number of citations of the paper that reports this interaction (PubMedID 25313011)
0

Data Source:
BioGRID (pull down)

		EEA1	RRAD
Description		early endosome antigen 1	RRAD, Ras related glycolysis inhibitor and calcium channel regulator
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Cytoplasmic Vesicle Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynaptic Endosome Postsynaptic Early Endosome Glutamatergic Synapse	Cytosol Plasma Membrane Membrane
	Molecular Function	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Metal Ion Binding	Nucleotide Binding GTPase Activity Calcium Channel Regulator Activity Protein Binding Calmodulin Binding GTP Binding
	Biological Process	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Chemical Synaptic Transmission, Postsynaptic	Small GTPase-mediated Signal Transduction
Pathways		Toll Like Receptor 9 (TLR9) Cascade	NGF-stimulated transcription
Drugs		Inositol 1,3-Bisphosphate
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)	Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		15 interacting genes: CDC73 IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 USP7 ZFYVE16	15 interacting genes: CALM1 CAMK2G CCDC141 CSNK2A1 CSNK2B EEA1 EGFR MMP14 NME1 PRKACA PRKCA PRKCB STAT3 TPM2 YWHAZ
Entrez ID		8411	6236
HPRD ID		05460	01536
Ensembl ID		ENSG00000102189	ENSG00000166592
Uniprot IDs		Q15075	P55042
PDB IDs		1HYI 1HYJ 1JOC 3MJH	2DPX 2GJS 3Q72 3Q7P 3Q7Q
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Early Endosome Early Endosome Membrane Intracellular Protein Transport Vesicle Organization Endomembrane System Endosomal Transport Protein Transport Endosome GDP Binding Intracellular Transport Phagocytic Vesicle Establishment Of Protein Localization Plasma Membrane To Endosome Transport Cellular Localization Establishment Of Localization In Cell Membrane Fusion GTPase Activity Intracellular Protein Localization GTP Binding Transcytosis Endosome Organization Endocytosis Vesicle Fusion Organelle Membrane Fusion Regulation Of Vesicle-mediated Transport Organelle Fusion Synaptic Vesicle Membrane Regulation Of Cellular Component Organization Organelle Organization Import Into Cell Vesicle Docking Endocytic Vesicle G Protein Activity Nucleotide Binding Organelle Localization By Membrane Tethering Phagocytic Vesicle Membrane Membrane Docking Melanosome Endosome Membrane Regulation Of Vesicle Size Regulation Of Endocytosis Membrane Organization Regulation Of Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Clearance Positive Regulation Of Protein-containing Complex Disassembly SNAP Receptor Activity Golgi Apparatus SNARE Complex	Kinase Activity Protein Serine/threonine Kinase Activity Phosphorylation Histone H3T6 Kinase Activity Cytosol Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Kinase C Signaling Regulation Of Protein Localization Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Protein Serine Kinase Activity Protein Phosphorylation Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Catabolic Process Positive Regulation Of Signal Transduction Positive Regulation Of Epithelial Cell Proliferation Cytoplasm Regulation Of Signal Transduction Mitotic Nuclear Membrane Disassembly Intracellular Signal Transduction Modulation Of Chemical Synaptic Transmission Establishment Of Protein Localization Identical Protein Binding Interleukin-2-mediated Signaling Pathway Intracellular Signaling Cassette Regulation Of Muscle System Process Positive Regulation Of Insulin Secretion Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphatase Binding Nuclear Membrane Disassembly ATP Binding Regulation Of Biological Quality Membrane Disassembly Negative Regulation Of Signal Transduction Diacylglycerol-dependent Serine/threonine Kinase Activity Signal Transduction Calyx Of Held Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Estradiol Negative Regulation Of Glycolytic Process Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Peptide Secretion
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