RAB5B and FHIP1B

Number of citations of the paper that reports this interaction (PubMedID 34882091)
68

Data Source:
BioGRID (proximity labelling technology, pull down, affinity chromatography technology)

		RAB5B	FHIP1B
Description		RAB5B, member RAS oncogene family	FHF complex subunit HOOK interacting protein 1B
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GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Synaptic Vesicle Membrane Early Endosome Membrane Melanosome Extracellular Exosome	FHF Complex
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Endosomal Transport Antigen Processing And Presentation Regulation Of Endocytosis Plasma Membrane To Endosome Transport	Endosome Organization Lysosome Organization Endosome To Lysosome Transport Protein Transport Early Endosome To Late Endosome Transport Protein Localization To Perinuclear Region Of Cytoplasm
Pathways		Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 30566500 22885925) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Interacting Genes		19 interacting genes: APOA5 CDK1 CHM EEA1 FHIP1B GLP1R HUNK PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SNCA SUN2 TBC1D15 TBC1D17 TFRC	9 interacting genes: AGTRAP AKTIP HOOK1 HOOK2 RAB5B RABAC1 REEP6 RTN1 RTN3
Entrez ID		5869	84067
HPRD ID		01544	08002
Ensembl ID		ENSG00000111540	ENSG00000051009
Uniprot IDs		P61020	Q8N612
PDB IDs		2HEI	8QAT
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport GTPase Activator Activity Endocytosis Import Into Cell Response To Copper Ion Small GTPase Binding Hsp70 Protein Binding Regulation Of Endocytosis Endocytic Vesicle Endosome Establishment Of Localization In Cell Endosomal Transport Regulation Of Cilium Assembly Intracellular Transport Regulation Of Vesicle-mediated Transport Early Endosome To Late Endosome Transport Regulation Of Receptor-mediated Endocytosis Intracellular Signal Transduction Early Endosome Recycling Endosome Response To Iron Ion Regulation Of Cellular Component Organization Pronuclear Fusion Cellular Localization Glucagon-like Peptide 1 Receptor Activity Ribonucleotide Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mast Cell Chemotaxis Regulation Of Transport	FHF Complex Protein Localization To Perinuclear Region Of Cytoplasm HOPS Complex Endosome Organization Early Endosome To Late Endosome Transport Endoplasmic Reticulum Organization Endoplasmic Reticulum Tubular Network Formation Lysosome Organization Endosome To Lysosome Transport Endosomal Transport Endoplasmic Reticulum Tubular Network Membrane Organization Vesicle Organization Endoplasmic Reticulum Membrane Organization Lysosomal Transport Organelle Organization Endoplasmic Reticulum Tubular Network Organization Negative Regulation Of Amyloid-beta Formation Vacuolar Transport Negative Regulation Of Amyloid Precursor Protein Catabolic Process Vacuole Organization Dynein Light Intermediate Chain Binding Vesicle-mediated Transport Regulation Of Amyloid-beta Formation Golgi Apparatus Regulation Of Amyloid Precursor Protein Catabolic Process Cytoplasmic Microtubule Organization Regulation Of Amide Metabolic Process Endoplasmic Reticulum Membrane Protein Transport Intracellular Transport Angiotensin Type II Receptor Activity Establishment Of Protein Localization Golgi Membrane Manchette Assembly Cytoskeleton-dependent Intracellular Transport Cellular Localization Plasma Membrane To Endosome Transport Endoplasmic Reticulum Positive Regulation Of Protein Binding Establishment Of Localization In Cell Brain Development Postsynaptic Density Microtubule Binding Cytoplasmic Vesicle Intracellular Protein Localization Identical Protein Binding Proline-rich Region Binding Ubiquitin-like Protein Transferase Activity GTP-dependent Protein Binding Angiotensin-activated Signaling Pathway
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