EEA1 and RAB5A

Number of citations of the paper that reports this interaction (PubMedID 9697774)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		EEA1	RAB5A
Description		early endosome antigen 1	RAB5A, member RAS oncogene family
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GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Cytoplasmic Vesicle Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynaptic Endosome Postsynaptic Early Endosome Glutamatergic Synapse	Ruffle Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Synaptic Vesicle Endosome Membrane Endomembrane System Actin Cytoskeleton Membrane Endocytic Vesicle Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Phagocytic Vesicle Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Somatodendritic Compartment Melanosome Cell Projection Neuronal Cell Body Terminal Bouton Axon Terminus Membrane Raft Phagocytic Vesicle Extracellular Exosome Cytoplasmic Side Of Early Endosome Membrane
	Molecular Function	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Metal Ion Binding	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity Guanyl Nucleotide Binding GDP Binding
	Biological Process	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Chemical Synaptic Transmission, Postsynaptic	Intracellular Protein Transport Endocytosis Phagocytosis Protein Transport Endosomal Transport Receptor Internalization Synaptic Vesicle Recycling Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Positive Regulation Of Exocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Plasma Membrane To Endosome Transport Regulation Of Endosome Size Regulation Of Filopodium Assembly Canonical Wnt Signaling Pathway Membrane Fusion Amyloid-beta Clearance By Transcytosis Protein Localization To Early Endosome Regulation Of Synaptic Vesicle Exocytosis Regulation Of Autophagosome Assembly
Pathways		Toll Like Receptor 9 (TLR9) Cascade	Synthesis of PIPs at the plasma membrane TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Prevention of phagosomal-lysosomal fusion Respiratory syncytial virus (RSV) attachment and entry Factors involved in megakaryocyte development and platelet production
Drugs		Inositol 1,3-Bisphosphate	L-methionine (S)-S-oxide Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)	Heel bone mineral density ( 30598549) Iris color (L* coordinate) ( 30895295)
Interacting Genes		15 interacting genes: CDC73 IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 USP7 ZFYVE16	37 interacting genes: AGTR1 ALS2CL ANKFY1 APPL1 APPL2 CHML EEA1 GDI2 GRIK4 HTATIP2 ITSN1 NME2 OCRL RAB37 RABAC1 RABEP1 RABEP2 RABGGTB RASA1 RBSN RIN1 RIN2 RIN3 RIT2 RUFY1 SDCBP SGSM3 SNCA STX4 TBC1D15 TBC1D17 TBC1D3C TBC1D3F TRIM14 TSC2 USP6NL WEE2-AS1
Entrez ID		8411	5868
HPRD ID		05460	01542
Ensembl ID		ENSG00000102189	ENSG00000144566
Uniprot IDs		Q15075	P20339
PDB IDs		1HYI 1HYJ 1JOC 3MJH	1N6H 1N6I 1N6K 1N6L 1N6N 1N6O 1N6P 1N6R 1R2Q 1TU3 1TU4 3MJH 4Q9U 7BL1
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Early Endosome Early Endosome Membrane Intracellular Protein Transport Vesicle Organization Endomembrane System Endosomal Transport Protein Transport Endosome GDP Binding Intracellular Transport Phagocytic Vesicle Establishment Of Protein Localization Plasma Membrane To Endosome Transport Cellular Localization Establishment Of Localization In Cell Membrane Fusion GTPase Activity Intracellular Protein Localization GTP Binding Transcytosis Endosome Organization Endocytosis Vesicle Fusion Organelle Membrane Fusion Regulation Of Vesicle-mediated Transport Organelle Fusion Synaptic Vesicle Membrane Regulation Of Cellular Component Organization Organelle Organization Import Into Cell Vesicle Docking Endocytic Vesicle G Protein Activity Nucleotide Binding Organelle Localization By Membrane Tethering Phagocytic Vesicle Membrane Membrane Docking Melanosome Endosome Membrane Regulation Of Vesicle Size Regulation Of Endocytosis Membrane Organization Regulation Of Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Clearance Positive Regulation Of Protein-containing Complex Disassembly SNAP Receptor Activity Golgi Apparatus SNARE Complex	GTPase Activator Activity Small GTPase Binding Vesicle-mediated Transport Endosome Regulation Of Endocytosis Regulation Of Vesicle-mediated Transport Endocytosis Cytoplasmic Vesicle Regulation Of Cellular Component Organization Cellular Localization Import Into Cell Intracellular Transport Regulation Of Cilium Assembly Endosomal Transport Small GTPase-mediated Signal Transduction Macropinosome Establishment Of Protein Localization Protein Transport Early Endosome Membrane Cytosol Establishment Of Localization In Cell Positive Regulation Of Pinocytosis Regulation Of Transport Early Endosome Regulation Of Organelle Assembly Cytoplasm Positive Regulation Of Macropinocytosis Regulation Of Cell Projection Assembly Endocytic Vesicle Membrane Fusion Positive Regulation Of Endocytosis Rab-protein Geranylgeranyltransferase Complex Phagocytic Vesicle Signal Transduction Intracellular Protein Localization Vesicle Fusion Retrograde Transport, Endosome To Golgi Protein Geranylgeranylation Organelle Membrane Fusion Ruffle Guanyl-nucleotide Exchange Factor Activity Synapse Adiponectin-activated Signaling Pathway Regulation Of Organelle Organization Protein Prenylation Organelle Fusion Cytosolic Transport Plasma Membrane To Endosome Transport Recycling Endosome Cell Projection
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