RAB5B and RABAC1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RAB5B	RABAC1
Gene Name		RAB5B, member RAS oncogene family	Rab acceptor 1 (prenylated)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Endosome Early Endosome Plasma Membrane Membrane Endocytic Vesicle Early Endosome Membrane Melanosome Extracellular Vesicular Exosome	Golgi Apparatus Plasma Membrane Synaptic Vesicle Membrane Integral Component Of Membrane Cell Junction
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	Protein Binding Protein C-terminus Binding Identical Protein Binding Proline-rich Region Binding
	Biological Process	Intracellular Protein Transport Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Plasma Membrane To Endosome Transport
Pathways
Drugs
Diseases
GWAS		Polycystic ovary syndrome ( 22885925) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Protein-Protein Interactions		15 interactors: APOA5 CDK1 CHM EEA1 RAB7A RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC	63 interactors: ADCK3 CMTM3 CREB3 DUSP12 FAM160A2 FXR2 GDI1 HRAS HRG LNX1 MAD2L1 MCF2L MIEF2 NAT14 NDRG4 NIF3L1 NR3C2 NUDT18 PBX3 PLEKHF2 PLK1 RAB17 RAB1A RAB22A RAB33A RAB3A RAB4A RAB4B RAB5A RAB5B RAB5C RAB6A RAB7A RAP1A RASD2 REEP5 RGS2 RHEB RHOA RIC8A RIMS2 RIN3 RPS20 RRAS2 SGK1 SNCA SNX1 SNX10 SNX11 SNX15 SPG21 SYT16 TNIP1 TRIM32 TSHR TUBB2A TXN2 VAMP2 VIM VTA1 WDYHV1 WIPI2 ZFYVE21
Entrez ID		5869	10567
HPRD ID		01544	05375
Ensembl ID		ENSG00000111540	ENSG00000105404
Uniprot IDs		P61020	Q9UI14
PDB IDs		2HEI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Vesicle-mediated Transport Endocytosis Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Endosomal Transport Regulation Of Ras GTPase Activity Organelle Fusion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Transport Early Endosome To Late Endosome Transport Membrane Organization Regulation Of Signaling Cellular Localization Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Vesicle Fusion Protein Localization Regulation Of Signal Transduction Establishment Of Localization In Cell Synaptic Vesicle To Endosome Fusion Pronuclear Fusion Epidermal Growth Factor Catabolic Process Retrograde Transport, Endosome To Golgi Nuclear Envelope Organization Organ Regeneration Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Intracellular Transport Nuclear Matrix Organization Negative Regulation Of Synaptic Plasticity Nuclear Matrix Anchoring At Nuclear Membrane Nucleus Organization Phagosome-lysosome Fusion Nuclear Migration Along Microfilament Regulation Of Metabolic Process Membrane Fusion Phagosome Acidification Protein Localization To Organelle Regulation Of Schwann Cell Differentiation Protein Geranylgeranylation Protein To Membrane Docking	Ras Protein Signal Transduction Rab Protein Signal Transduction Small GTPase Mediated Signal Transduction Establishment Of Protein Localization Protein Transport Protein Localization Cellular Protein Localization Cellular Localization Intracellular Protein Transport Regulation Of Cellular Component Organization Regulation Of Vesicle-mediated Transport Vesicle-mediated Transport Establishment Of Localization In Cell Intracellular Transport Intracellular Signal Transduction Endosomal Transport Regulation Of Exocytosis Transport Cellular Response To Stimulus Cell Communication Regulation Of Endocytosis Endocytosis Regulation Of Locomotion Vesicle Organization Endosome Organization Response To Stimulus Regulation Of Synaptic Vesicle Transport Regulation Of Cell Projection Organization Signaling Signal Transduction Cytoplasmic Transport Establishment Of Vesicle Localization Regulation Of Neuronal Synaptic Plasticity Vesicle Localization Regulation Of Organelle Organization Regulation Of Cell Migration Positive Regulation Of Metabolic Process Early Endosome To Late Endosome Transport Regulation Of Neurotransmitter Secretion Regulation Of Cell Motility Regulation Of Signaling Regulation Of Cellular Localization Regulation Of Cellular Component Movement Regulation Of Cellular Process Regulation Of Synaptic Plasticity Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Transport Synaptic Vesicle Recycling Endomembrane System Organization
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