EEA1

Description		early endosome antigen 1
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Membrane Cytoplasmic Vesicle Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Exosome Schaffer Collateral - CA1 Synapse Presynaptic Endosome Postsynaptic Early Endosome Glutamatergic Synapse
	Molecular Function	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Host-mediated Perturbation Of Viral Process Early Endosome To Late Endosome Transport Chemical Synaptic Transmission, Postsynaptic
Pathways		Toll Like Receptor 9 (TLR9) Cascade
Drugs		Inositol 1,3-Bisphosphate
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Sensorimotor dexterity ( 31596458) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Western dietary pattern ( 28644415)
Interacting Genes		15 interacting genes: CDC73 IGF1R MAPK14 RAB22A RAB31 RAB5A RAB5B RAB5C RRAD STX12 STX6 TOM1 USO1 USP7 ZFYVE16
Entrez ID		8411
HPRD ID		05460
Ensembl ID		ENSG00000102189
Uniprot IDs		Q15075
PDB IDs		1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport Early Endosome Early Endosome Membrane Intracellular Protein Transport Vesicle Organization Endomembrane System Endosomal Transport Protein Transport Endosome GDP Binding Intracellular Transport Phagocytic Vesicle Establishment Of Protein Localization Plasma Membrane To Endosome Transport Cellular Localization Establishment Of Localization In Cell Membrane Fusion GTPase Activity Intracellular Protein Localization GTP Binding Transcytosis Endosome Organization Endocytosis Vesicle Fusion Organelle Membrane Fusion Regulation Of Vesicle-mediated Transport Organelle Fusion Synaptic Vesicle Membrane Regulation Of Cellular Component Organization Organelle Organization Import Into Cell Vesicle Docking Endocytic Vesicle G Protein Activity Nucleotide Binding Organelle Localization By Membrane Tethering Phagocytic Vesicle Membrane Membrane Docking Melanosome Endosome Membrane Regulation Of Vesicle Size Regulation Of Endocytosis Membrane Organization Regulation Of Transport Vesicle-mediated Transport To The Plasma Membrane Amyloid-beta Clearance Positive Regulation Of Protein-containing Complex Disassembly SNAP Receptor Activity Golgi Apparatus SNARE Complex
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