RAB5B and APOA5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RAB5B	APOA5
Gene Name		RAB5B, member RAS oncogene family	apolipoprotein A-V
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Endosome Early Endosome Plasma Membrane Membrane Endocytic Vesicle Early Endosome Membrane Melanosome Extracellular Vesicular Exosome	Extracellular Region Extracellular Space Very-low-density Lipoprotein Particle Low-density Lipoprotein Particle High-density Lipoprotein Particle Chylomicron Blood Microparticle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	Phospholipid Binding Enzyme Activator Activity Heparin Binding Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Enzyme Binding Phosphatidylcholine Binding Lipase Binding Low-density Lipoprotein Particle Receptor Binding Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipase Activator Activity Lipoprotein Lipase Activator Activity Lipoprotein Particle Receptor Binding
	Biological Process	Intracellular Protein Transport Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Plasma Membrane To Endosome Transport	Triglyceride Metabolic Process Cholesterol Biosynthetic Process Lipid Transport Response To Hormone Positive Regulation Of Cholesterol Esterification Positive Regulation Of Triglyceride Catabolic Process Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Triglyceride Catabolic Process Regulation Of Intestinal Cholesterol Absorption Organ Regeneration Neuron Projection Regeneration Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly Lipoprotein Metabolic Process Tissue Regeneration Cholesterol Homeostasis Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Fatty Acid Biosynthetic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipid Catabolic Process Positive Regulation Of Lipoprotein Lipase Activity Acylglycerol Homeostasis Triglyceride Homeostasis
Pathways			Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport
Drugs
Diseases
GWAS		Polycystic ovary syndrome ( 22885925) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)	Cardiovascular disease risk factors ( 20838585) Carotenoid and tocopherol levels ( 19185284) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990 21347282) HDL cholesterol ( 20864672 19060906 20686565) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) Hematological and biochemical traits ( 20139978) Hypertriglyceridemia ( 23505323 20657596) LDL cholesterol ( 18179892 20864672 19060911 20686565) Lipid metabolism phenotypes ( 22286219) Metabolic syndrome ( 21386085) Metabolite levels ( 22916037) Obesity-related traits ( 23251661) Phospholipid levels (plasma) ( 22359512) Response to Vitamin E supplementation ( 22437554) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 22171074 20139978 20686565) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Vitamin E levels ( 21729881) Waist Circumference - Triglycerides (WC-TG) ( 21386085)
Protein-Protein Interactions		15 interactors: APOA5 CDK1 CHM EEA1 RAB7A RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC	3 interactors: FAS RAB5B SMARCD1
Entrez ID		5869	116519
HPRD ID		01544	06966
Ensembl ID		ENSG00000111540	ENSG00000110243
Uniprot IDs		P61020	Q6Q788
PDB IDs		2HEI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Vesicle-mediated Transport Endocytosis Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Endosomal Transport Regulation Of Ras GTPase Activity Organelle Fusion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Transport Early Endosome To Late Endosome Transport Membrane Organization Regulation Of Signaling Cellular Localization Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Vesicle Fusion Protein Localization Regulation Of Signal Transduction Establishment Of Localization In Cell Synaptic Vesicle To Endosome Fusion Pronuclear Fusion Epidermal Growth Factor Catabolic Process Retrograde Transport, Endosome To Golgi Nuclear Envelope Organization Organ Regeneration Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Intracellular Transport Nuclear Matrix Organization Negative Regulation Of Synaptic Plasticity Nuclear Matrix Anchoring At Nuclear Membrane Nucleus Organization Phagosome-lysosome Fusion Nuclear Migration Along Microfilament Regulation Of Metabolic Process Membrane Fusion Phagosome Acidification Protein Localization To Organelle Regulation Of Schwann Cell Differentiation Protein Geranylgeranylation Protein To Membrane Docking	Motor Neuron Apoptotic Process Necroptotic Signaling Pathway Transformed Cell Apoptotic Process Activation-induced Cell Death Of T Cells Plasma Membrane To Endosome Transport Inflammatory Cell Apoptotic Process Cellular Response To Hyperoxia Positive Regulation Of Protein Homooligomerization Chromatin-mediated Maintenance Of Transcription Pantothenate Metabolic Process Negative Thymic T Cell Selection Negative T Cell Selection Nucleosome Disassembly Long-chain Fatty-acyl-CoA Biosynthetic Process Cellular Response To Lithium Ion T Cell Apoptotic Process Positive Regulation Of Gene Expression, Epigenetic Fatty-acyl-CoA Biosynthetic Process Positive Regulation Of Protein Oligomerization Hepatocyte Apoptotic Process Thymic T Cell Selection Acetyl-CoA Metabolic Process Long-chain Fatty-acyl-CoA Metabolic Process Regulation Of Protein Oligomerization Endosome Organization Response To Lithium Ion Necroptotic Process Response To Hyperoxia Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand T Cell Homeostasis Negative Regulation Of B Cell Activation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors T Cell Selection Cellular Response To Interleukin-4 Spleen Development Triglyceride Biosynthetic Process Programmed Necrotic Cell Death Necrotic Cell Death Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Interleukin-4 Neuron Apoptotic Process Rab Protein Signal Transduction Immunoglobulin Production Acyl-CoA Metabolic Process Neuron Death T Cell Differentiation In Thymus Lymphocyte Homeostasis Cellular Response To Mechanical Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Tagcloud ?			ago alleles apolipoprotein carriers cholesterol coding connected damaging disordered displays exome functionally genomes harbour infarction inheritance ldl ldlr lipase lipoprotein lipoproteins mi namely rare refs sequenced synonymous triglyceride triglycerides
Tagcloud (Difference) ?			ago alleles apolipoprotein carriers cholesterol coding connected damaging disordered displays exome functionally genomes harbour infarction inheritance ldl ldlr lipase lipoprotein lipoproteins mi namely rare refs sequenced synonymous triglyceride triglycerides
Tagcloud (Intersection) ?