RAB5B and TBC1D17

Number of citations of the paper that reports this interaction (PMID 16923123)
31

Data Source:
BioGRID (two hybrid)

		RAB5B	TBC1D17
Gene Name		RAB5B, member RAS oncogene family	TBC1 domain family, member 17
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Endosome Early Endosome Plasma Membrane Membrane Endocytic Vesicle Early Endosome Membrane Melanosome Extracellular Vesicular Exosome	Autophagic Vacuole Cytosol Cytoplasmic Vesicle
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding GTP-dependent Protein Binding	Rab GTPase Activator Activity Protein Binding
	Biological Process	Intracellular Protein Transport Endosome Organization Antigen Processing And Presentation Regulation Of Endocytosis Rab Protein Signal Transduction Plasma Membrane To Endosome Transport	Autophagy Protein Transport Positive Regulation Of Rab GTPase Activity Retrograde Transport, Endosome To Golgi Regulation Of Cilium Assembly
Pathways
Drugs
Diseases
GWAS		Polycystic ovary syndrome ( 22885925) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)
Protein-Protein Interactions		15 interactors: APOA5 CDK1 CHM EEA1 RAB7A RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SUN2 TBC1D15 TBC1D17 TFRC	19 interactors: ASCC2 CALCOCO1 CCT5 CDKN2D DHX29 FBL GABARAPL1 GPS1 GTF3C1 MAP1LC3A MAP1LC3B NIPSNAP1 OPTN RAB1A RAB5A RAB5B RAB5C SLC1A5 TAX1BP1
Entrez ID		5869	79735
HPRD ID		01544	15471
Ensembl ID		ENSG00000111540	ENSG00000104946
Uniprot IDs		P61020	Q9HA65
PDB IDs		2HEI
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Rab GTPase Activity Regulation Of Rab GTPase Activity Regulation Of Rab Protein Signal Transduction Positive Regulation Of Catalytic Activity Positive Regulation Of Hydrolase Activity Positive Regulation Of GTPase Activity Regulation Of GTPase Activity Vesicle-mediated Transport Endocytosis Regulation Of Catalytic Activity Positive Regulation Of Ras GTPase Activity Endosomal Transport Regulation Of Ras GTPase Activity Organelle Fusion Regulation Of Ras Protein Signal Transduction Positive Regulation Of Metabolic Process Regulation Of Small GTPase Mediated Signal Transduction Transport Early Endosome To Late Endosome Transport Membrane Organization Regulation Of Signaling Cellular Localization Ras Protein Signal Transduction Regulation Of Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Vesicle Fusion Protein Localization Regulation Of Signal Transduction Establishment Of Localization In Cell Synaptic Vesicle To Endosome Fusion Pronuclear Fusion Epidermal Growth Factor Catabolic Process Retrograde Transport, Endosome To Golgi Nuclear Envelope Organization Organ Regeneration Positive Regulation Of Very-low-density Lipoprotein Particle Remodeling Intracellular Transport Nuclear Matrix Organization Negative Regulation Of Synaptic Plasticity Nuclear Matrix Anchoring At Nuclear Membrane Nucleus Organization Phagosome-lysosome Fusion Nuclear Migration Along Microfilament Regulation Of Metabolic Process Membrane Fusion Phagosome Acidification Protein Localization To Organelle Regulation Of Schwann Cell Differentiation Protein Geranylgeranylation Protein To Membrane Docking	Macroautophagy Autophagic Vacuole Assembly Cellular Response To Starvation Rab Protein Signal Transduction Autophagy Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Nucleophagy Response To Nutrient Levels Response To Extracellular Stimulus Vacuole Organization Mitochondrion Degradation Organelle Disassembly Plasma Membrane To Endosome Transport Ras Protein Signal Transduction Response To External Stimulus Cellular Response To Nitrogen Starvation Cellular Response To Stress Membrane Fusion Cytoplasmic Transport Regulation Of Endocytosis Membrane Organization Organelle Assembly Response To Stimulus Endosomal Transport Intracellular Protein Transport Response To Stress Histone Glutamine Methylation Extracellular Amino Acid Transport Small GTPase Mediated Signal Transduction Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Peptidyl-glutamine Methylation Golgi Organization Response To Other Organism Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Response To Biotic Stimulus Regulation Of Vesicle-mediated Transport Interleukin-8 Production SnoRNA Metabolic Process Negative Regulation Of Receptor Recycling Cellular Protein Localization Mitochondrion Organization Protein Transport Negative Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Endomembrane System Organization 5S Class RRNA Transcription From RNA Polymerase III Type 1 Promoter
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