EEA1 and RAB22A

Number of citations of the paper that reports this interaction (PMID 11870209)
37

Data Source:
HPRD (two hybrid, in vitro)

		EEA1	RAB22A
Gene Name		early endosome antigen 1	RAB22A, member RAS oncogene family
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Serine-pyruvate Aminotransferase Complex Membrane Extrinsic Component Of Plasma Membrane Cytoplasmic Vesicle Early Endosome Membrane Axonal Spine Recycling Endosome Extracellular Vesicular Exosome	Ruffle Early Endosome Plasma Membrane Endosome Membrane Actin Cytoskeleton Phagocytic Vesicle Membrane Phagocytic Vesicle Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Zinc Ion Binding GTP-dependent Protein Binding Protein Homodimerization Activity	GTPase Activity Protein Binding GTP Binding GDP Binding
	Biological Process	Endocytosis Vesicle Fusion Synaptic Vesicle To Endosome Fusion Early Endosome To Late Endosome Transport	Intracellular Protein Transport Endocytosis Endosome Organization Rab Protein Signal Transduction Regulation Of Vesicle Size
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 9 (TLR9) Cascade Innate Immune System
Drugs		Inositol 1,3-Bisphosphate
Diseases
GWAS
Protein-Protein Interactions		11 interactors: IGF1R MAPK14 RAB22A RAB5A RAB5B RAB5C STX12 STX6 TOM1 USO1 ZFYVE16	6 interactors: APPL2 EEA1 RAB3GAP1 RAB7A RABAC1 SMURF2
Entrez ID		8411	57403
HPRD ID		05460	06696
Ensembl ID		ENSG00000102189	ENSG00000124209
Uniprot IDs		Q15075	Q9UL26
PDB IDs		1HYI 1HYJ 1JOC 3MJH
Enriched GO Terms of Interacting Partners?		Intracellular Protein Transport Endosomal Transport Cellular Protein Localization Protein Transport Establishment Of Protein Localization Intracellular Transport Protein Localization Establishment Of Localization In Cell Rab Protein Signal Transduction Vesicle-mediated Transport Ras Protein Signal Transduction Cellular Localization Endosome Organization Regulation Of Endocytosis Vesicle Fusion Vesicle Organization Plasma Membrane To Endosome Transport Small GTPase Mediated Signal Transduction Organelle Fusion Cytoplasmic Transport Regulation Of Vesicle-mediated Transport Membrane Fusion Transport Intracellular Signal Transduction Regulation Of Cellular Component Organization Organelle Organization P38MAPK Cascade Inactivation Of MAPKK Activity Vesicle Docking Membrane Docking Endomembrane System Organization Regulation Of Vesicle Size Golgi Vesicle Docking Receptor Internalization Involved In Canonical Wnt Signaling Pathway Regulation Of Endosome Size Positive Regulation Of Brown Fat Cell Differentiation Myoblast Differentiation Involved In Skeletal Muscle Regeneration Regulation Of Brown Fat Cell Differentiation Endocytosis Golgi Ribbon Formation Signal Transduction Positive Regulation Of Steroid Hormone Biosynthetic Process Exocrine Pancreas Development Vesicle Fusion With Golgi Apparatus Positive Regulation Of Hormone Biosynthetic Process 3'-UTR-mediated MRNA Stabilization Stress-induced Premature Senescence Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein Targeting To Lysosome	Early Endosome To Late Endosome Transport Vesicle Fusion Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Organelle Fusion Regulation Of ERBB Signaling Pathway Synaptic Vesicle To Endosome Fusion Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Epidermal Growth Factor Catabolic Process Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Membrane Fusion Positive Regulation Of Endoplasmic Reticulum Tubular Network Organization Membrane Organization Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Endosomal Transport Vesicle Organization Signaling Phagosome-lysosome Fusion Cell Communication Regulation Of Signal Transduction Phagosome Acidification Positive Regulation Of Glutamate Secretion Regulation Of Signaling Ubiquitin-dependent SMAD Protein Catabolic Process Protein To Membrane Docking Positive Regulation Of Secretion Establishment Of Protein Localization To Organelle Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Positive Regulation Of Amino Acid Transport Protein Targeting To Lysosome Regulation Of Glutamate Secretion Regulation Of Short-term Neuronal Synaptic Plasticity Lipid Particle Organization Phagolysosome Assembly Protein Localization To Lysosome Cellular Cation Homeostasis Regulation Of Autophagic Vacuole Assembly Positive Regulation Of Neurotransmitter Secretion Forebrain Development Cellular Ion Homeostasis Cellular Copper Ion Homeostasis Regulation Of Vacuole Organization Intracellular PH Reduction Protein Localization To Organelle Protein Targeting To Vacuole PH Reduction Copper Ion Homeostasis Suckling Behavior Cellular Chemical Homeostasis Hypothalamus Development
Tagcloud ?		appl1 characterised colocalisation colocalises compartments employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	casein cisternae ck2alpha complemented efflux exocytic exome fragmented gap gtpase guanine huh7 ile34phe junction lucifer morphologies pyrophosphatase thiamine trafficking transferrin trf1 trf2 trf4 trf5 trf6 trf7 vsv yellow
Tagcloud (Difference) ?		appl1 characterised colocalisation colocalises compartments employ endocytic endosome endosomes engages entered escrt gradually intermediates intralumenal labelled localise localises move snx15 solely sorts subpixel suite transit transporting ubiquitinated vacuolar whilst	casein cisternae ck2alpha complemented efflux exocytic exome fragmented gap gtpase guanine huh7 ile34phe junction lucifer morphologies pyrophosphatase thiamine trafficking transferrin trf1 trf2 trf4 trf5 trf6 trf7 vsv yellow
Tagcloud (Intersection) ?