RAB5B and CHM

Number of citations of the paper that reports this interaction (PubMedID 35271311)
106

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid)

		RAB5B	CHM
Description		RAB5B, member RAS oncogene family	CHM Rab escort protein
Image			No pdb structure
GO Annotations	Cellular Component	Endosome Early Endosome Plasma Membrane Endomembrane System Membrane Endocytic Vesicle Secretory Granule Membrane Synaptic Vesicle Membrane Early Endosome Membrane Melanosome Extracellular Exosome	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex
	Molecular Function	Nucleotide Binding GTPase Activity G Protein Activity Protein Binding GTP Binding Hydrolase Activity GDP Binding GTP-dependent Protein Binding Metal Ion Binding	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding
	Biological Process	Intracellular Protein Transport Endocytosis Endosome Organization Protein Transport Endosomal Transport Antigen Processing And Presentation Regulation Of Endocytosis Plasma Membrane To Endosome Transport	Protein Targeting To Membrane Intracellular Protein Transport Small GTPase-mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Geranylgeranylation
Pathways		Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs Respiratory syncytial virus (RSV) attachment and entry	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Choroideremia (CHM); Tapetochoroidal dystrophy
GWAS		Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29785011) Anorexia nervosa ( 28494655) Aspartate aminotransferase levels ( 33547301) Asthma ( 31959851 31619474 30929738) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 30929738 31036433) Asthma or allergic disease (pleiotropy) ( 29785011) Brain morphology (MOSTest) ( 32665545) Cognitive function ( 25644384) FEV1 ( 30804560) Gastroesophageal reflux disease ( 31527586) HDL cholesterol levels ( 32203549) High density lipoprotein cholesterol levels ( 31928498) Lung function (FEV1) ( 30061609) Lung function (FEV1/FVC) ( 30804560) Medication use (drugs for peptic ulcer and gastro-oesophageal reflux disease) ( 31015401) Polycystic ovary syndrome ( 30566500 22885925) Refractive error ( 32231278) Sum eosinophil basophil counts ( 27863252) Type 1 diabetes ( 18198356) Vitiligo ( 22951725)	Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)
Interacting Genes		19 interacting genes: APOA5 CDK1 CHM EEA1 FHIP1B GLP1R HUNK PIK3CB RABAC1 REEP5 RIN1 RIN2 RIN3 SGSM3 SNCA SUN2 TBC1D15 TBC1D17 TFRC	11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A
Entrez ID		5869	1121
HPRD ID		01544	02312
Ensembl ID		ENSG00000111540	ENSG00000188419
Uniprot IDs		P61020	A8K545 B4DRL9 P24386
PDB IDs		2HEI
Enriched GO Terms of Interacting Partners?		Vesicle-mediated Transport GTPase Activator Activity Endocytosis Import Into Cell Response To Copper Ion Small GTPase Binding Hsp70 Protein Binding Regulation Of Endocytosis Endocytic Vesicle Endosome Establishment Of Localization In Cell Endosomal Transport Regulation Of Cilium Assembly Intracellular Transport Regulation Of Vesicle-mediated Transport Early Endosome To Late Endosome Transport Regulation Of Receptor-mediated Endocytosis Intracellular Signal Transduction Early Endosome Recycling Endosome Response To Iron Ion Regulation Of Cellular Component Organization Pronuclear Fusion Cellular Localization Glucagon-like Peptide 1 Receptor Activity Ribonucleotide Binding Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Mast Cell Chemotaxis Regulation Of Transport	GTPase Activity GTP Binding Protein Transport Myosin V Binding Establishment Of Protein Localization GTP-dependent Protein Binding GDP Binding Hydrolase Activity Nucleotide Binding Intracellular Protein Localization Vesicle-mediated Transport G Protein Activity Secretory Granule Membrane Antigen Processing And Presentation Endomembrane System Intracellular Protein Transport Phagosome Maturation Endosome Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Vesicle Organization Synaptic Vesicle Membrane Intracellular Transport Vesicle Golgi Apparatus Regulation Of Exocytosis Extracellular Exosome Cellular Localization Endosomal Transport Phagocytic Vesicle Positive Regulation Of Exocytosis Vesicle-mediated Transport In Synapse Retrograde Transport, Endosome To Golgi Synaptic Vesicle Recycling Membrane Perinuclear Region Of Cytoplasm Early Endosome To Golgi Transport Cytosolic Transport Synaptic Vesicle Melanosome Membrane Phagophore Assembly Site Membrane Cytoplasmic Vesicle Bone Resorption Vacuole Organization Regulation Of Transport Trans-Golgi Network Exocytosis Early Endosome Membrane Localization Within Membrane Organelle Organization
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