TBC1D10A and ACD

Number of citations of the paper that reports this interaction (PubMedID 21044950)
82

Data Source:
BioGRID (two hybrid)

		TBC1D10A	ACD
Description		TBC1 domain family member 10A	ACD shelterin complex subunit and telomerase recruitment factor
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Microvillus Cell Projection Extracellular Exosome	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleus Nucleoplasm Chromosome Telomerase Holoenzyme Complex Nuclear Body Shelterin Complex
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding PDZ Domain Binding Cadherin Binding	DNA Binding Protein Binding Telomerase Inhibitor Activity Telomeric DNA Binding Protein-containing Complex Binding DNA Polymerase Binding
	Biological Process	Retrograde Transport, Endosome To Golgi Positive Regulation Of Proteolysis Regulation Of Cilium Assembly	Telomere Maintenance Skeletal System Development Urogenital System Development Intracellular Protein Transport Telomere Maintenance Via Telomerase Telomere Capping Embryonic Limb Morphogenesis Protection From Non-homologous End Joining At Telomere Telomere Assembly Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Segmentation Protein Localization To Chromosome, Telomeric Region Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Telomere
Pathways		TBC/RABGAPs	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase Polymerase switching on the C-strand of the telomere Processive synthesis on the C-strand of the telomere Telomere C-strand (Lagging Strand) Synthesis Telomere C-strand synthesis initiation Removal of the Flap Intermediate from the C-strand DNA Damage/Telomere Stress Induced Senescence Inhibition of DNA recombination at telomere
Drugs
Diseases
GWAS		Delirium ( 29631748) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Hemoglobin levels ( 32327693) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		9 interacting genes: ACD EZR GABARAPL1 MAP1LC3A NHERF1 NHERF2 TERF1 TERF2IP TEX13A	64 interacting genes: ACTB ADPRH AFAP1L2 AIPL1 ANKMY2 ANXA8L1 APOBEC3F BAG3 CKB CTTN DBN1 DBNL DCX DPYSL3 EIF3G EIF4B ENO2 ENSA FAM131B FBXW7 FKBP6 GAPDH HSP90AB1 IPO5 IVL LASP1 LDHA LGALSL LLGL1 LRRC25 NCDN NTAQ1 NUDC NUDCD2 PAGE2 PDLIM2 PEX5 PFKP PGM2 POT1 RBKS RECQL4 RGS3 RPSA SBDS STIP1 STUB1 SULT1C2 TAGLN TBC1D10A TBCD TINF2 TOMM34 TRIM15 TRIM16 TRIM55 TRIM63 TUBB2A TUBB4B USP7 XRCC6 YWHAE ZFP36L1 ZNF790
Entrez ID		83874	65057
HPRD ID		18162	12417
Ensembl ID		ENSG00000099992	ENSG00000102977
Uniprot IDs		A7E244 B7ZVY9 Q9BXI6	A0A8Q3WM11 Q96AP0
PDB IDs			2I46 5H65 5I2X 5I2Y 5UN7 5XYF 7QXA 7QXB 7QXS 7S1T 7TRE 8SOJ 8SOK
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Type 2 Metabotropic Glutamate Receptor Binding Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Type 3 Metabotropic Glutamate Receptor Binding Negative Regulation Of Telomere Maintenance Phosphatase Binding Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Microvillus Assembly Protection From Non-homologous End Joining At Telomere Positive Regulation Of Telomere Maintenance Microvillus Organization Negative Regulation Of Chromosome Organization DNA Biosynthetic Process G-rich Strand Telomeric DNA Binding Cellular Response To Nitrogen Starvation Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Phosphatidylethanolamine Binding Telomere Maintenance In Response To DNA Damage Cellular Component Assembly Telomere Organization Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of DNA Metabolic Process Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Negative Regulation Of DNA Biosynthetic Process Protein Localization To Plasma Membrane Protein-membrane Adaptor Activity Protein Localization To Cell Periphery Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Microtubule Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity	Cytoplasm Cytosol Cadherin Binding Carbohydrate Catabolic Process Nuclear Telomere Cap Complex Protein Folding Chaperone Complex Substantia Nigra Development ADP Catabolic Process Purine Ribonucleoside Diphosphate Catabolic Process Glycolytic Process Telomere Maintenance Cellular Response To Heat ADP Metabolic Process Nicotinamide Nucleotide Metabolic Process Nucleoside Diphosphate Catabolic Process Monosaccharide Metabolic Process Ribonucleoside Diphosphate Catabolic Process Unfolded Protein Binding Telomeric D-loop Binding Telomere Assembly Organelle Organization Neural Nucleus Development Pyruvate Metabolic Process Glucose Metabolic Process Telomere Organization Protein Folding Cortical Cytoskeleton Glucose Catabolic Process Telomeric DNA Binding Protein Binding Shelterin Complex Ribonucleoside Diphosphate Metabolic Process Purine Ribonucleotide Catabolic Process Structural Constituent Of Postsynaptic Actin Cytoskeleton Cytoskeleton Organization Cytoskeleton Microtubule Cytoskeleton Organization Nucleoside Diphosphate Metabolic Process Protein Stabilization Chaperone-mediated Autophagy Microtubule Response To Heat Purine Nucleotide Catabolic Process Nitric-oxide Synthase Regulator Activity TPR Domain Binding Hexose Metabolic Process Microtubule Cytoskeleton Intercellular Bridge Telomeric D-loop Disassembly Hsp90 Protein Binding
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