TBC1D10A and SLC9A3R1

Number of citations of the paper that reports this interaction (PMID 11285285)
21

Data Source:
HPRD (in vivo, in vitro)

		TBC1D10A	SLC9A3R1
Gene Name		TBC1 domain family, member 10A	solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Microvillus Extracellular Vesicular Exosome	Ruffle Nucleus Cytoplasm Centrosome Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Vesicular Exosome Cell Periphery Sperm Midpiece
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Rab GTPase Activator Activity Protein Binding PDZ Domain Binding	Receptor Binding Protein Binding Beta-catenin Binding Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Protein Complex Binding Protein Complex Scaffold Protein Self-association Dopamine Receptor Binding Growth Factor Receptor Binding
	Biological Process	Positive Regulation Of Rab GTPase Activity Retrograde Transport, Endosome To Golgi Positive Regulation Of Proteolysis Activation Of Cysteine-type Endopeptidase Activity Regulation Of Cilium Assembly	Renal Sodium Ion Transport Protein Complex Assembly Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Wnt Signaling Pathway Microvillus Assembly Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Cellular Phosphate Ion Homeostasis Regulation Of Sodium:proton Antiporter Activity Negative Regulation Of Sodium:proton Antiporter Activity Bile Acid Secretion Cellular Protein Localization Glutathione Transport Regulation Of Excretion Regulation Of Protein Kinase Activity Negative Regulation Of Protein Kinase B Signaling Phospholipase C-activating Dopamine Receptor Signaling Pathway Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Renal Phosphate Ion Absorption Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Fibrinogen ( 20031577)
Protein-Protein Interactions		9 interactors: ACD EZR GABARAPL1 MAP1LC3A SLC9A3R1 SLC9A3R2 TERF1 TERF2IP TEX13A	52 interactors: ABCC2 ABCC4 ADRB2 AKAP10 ATP6V1B1 ATP6V1E1 BCL10 CFTR CLCN3 CNGA2 CTNNB1 EGFR EZR GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PDZK1 PIK3CA PLCB1 PLCB2 PTEN PTH1R RDX RLBP1 SCN4A SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 TBC1D10A TRPC4 TRPC5 YAP1 YES1 ZNF468
Entrez ID		83874	9368
HPRD ID		18162	05406
Ensembl ID		ENSG00000099992	ENSG00000109062
Uniprot IDs		A7E244 B7ZVY9 Q20WK7 Q9BXI6	O14745
PDB IDs			1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Cellular Component Assembly Protection From Non-homologous End Joining At Telomere Telomere Capping Protein Localization To Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Negative Regulation Of Chromosome Organization Negative Regulation Of DNA Metabolic Process Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomerase Organelle Organization Regulation Of Telomerase Activity Microvillus Assembly Microvillus Organization Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Nucleophagy RNA-dependent DNA Replication Regulation Of Chromosome Organization Mitochondrion Degradation Protein Localization To Chromosome Telomere Maintenance Via Telomere Lengthening Organelle Disassembly Autophagic Vacuole Assembly Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Macroautophagy Positive Regulation Of Single-stranded Telomeric DNA Binding Renal Phosphate Ion Absorption Negative Regulation Of DNA Recombination At Telomere Regulation Of Phosphatidylinositol 3-kinase Signaling Vacuole Organization Cellular Protein Localization Homeostatic Process Negative Regulation Of Sodium:proton Antiporter Activity Glutathione Transport Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Replication Membrane Fusion Cellular Response To Starvation Cellular Response To Stress Telomeric Loop Formation Age-dependent Telomere Shortening Autophagy Telomere Maintenance Via Telomere Shortening Cellular Response To Nutrient Levels Response To Starvation Renal Sodium Ion Transport Membrane To Membrane Docking	Ion Homeostasis Ion Transmembrane Transport Transmembrane Transport Homeostatic Process Ion Transport Anion Transport Organic Anion Transport Anion Transmembrane Transport Chemical Homeostasis Cellular Ion Homeostasis Positive Regulation Of Phospholipase C Activity Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Regulation Of PH Response To Organonitrogen Compound Cellular Chemical Homeostasis Monocarboxylic Acid Transport Positive Regulation Of Phospholipase Activity Transport Cellular Cation Homeostasis G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Regulation Of Vasodilation Regulation Of Phosphorus Metabolic Process Cellular Response To Organonitrogen Compound Response To Stimulus Inorganic Anion Transport Regulation Of Ion Transport Regulation Of Membrane Potential Cell Development Response To External Stimulus Monovalent Inorganic Cation Transport Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Metal Ion Transport Cellular Homeostasis Establishment Of Endothelial Barrier Regulation Of Ion Transmembrane Transport Blood Coagulation Response To Estrogen Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Hemostasis Regulation Of Body Fluid Levels Signaling Wound Healing Response To Organic Substance Response To Hormone Cell Surface Receptor Signaling Pathway Cell Communication Cation Transport Positive Regulation Of Inositol Phosphate Biosynthetic Process
Tagcloud ?			adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Difference) ?			adipogenic alters amscs chondrogenic commitment deacetylases destabilizes foxo1 grown hdac hdac1 hdac11 hydroxamic hyper interferes lysate manipulation mechanistically mesenchymal multipotency multipotent nherf1 osteogenic perturbation pluripotent saha sirt7 suberoylanilide uncommitted
Tagcloud (Intersection) ?