TBC1D10A and NHERF2

Number of citations of the paper that reports this interaction (PubMedID 11285285)
70

Data Source:
HPRD (in vitro)

		TBC1D10A	NHERF2
Description		TBC1 domain family member 10A	NHERF family PDZ scaffold protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Microvillus Cell Projection Extracellular Exosome	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding PDZ Domain Binding Cadherin Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	Retrograde Transport, Endosome To Golgi Positive Regulation Of Proteolysis Regulation Of Cilium Assembly	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		TBC/RABGAPs
Drugs
Diseases
GWAS		Delirium ( 29631748) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		9 interacting genes: ACD EZR GABARAPL1 MAP1LC3A NHERF1 NHERF2 TERF1 TERF2IP TEX13A	46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		83874	9351
HPRD ID		18162	05946
Ensembl ID		ENSG00000099992	ENSG00000065054
Uniprot IDs		A7E244 B7ZVY9 Q9BXI6	H3BQS0 Q15599
PDB IDs			2D11 2HE4 2OCS 4P0C
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Type 2 Metabotropic Glutamate Receptor Binding Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Type 3 Metabotropic Glutamate Receptor Binding Negative Regulation Of Telomere Maintenance Phosphatase Binding Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Microvillus Assembly Protection From Non-homologous End Joining At Telomere Positive Regulation Of Telomere Maintenance Microvillus Organization Negative Regulation Of Chromosome Organization DNA Biosynthetic Process G-rich Strand Telomeric DNA Binding Cellular Response To Nitrogen Starvation Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Phosphatidylethanolamine Binding Telomere Maintenance In Response To DNA Damage Cellular Component Assembly Telomere Organization Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of DNA Metabolic Process Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Negative Regulation Of DNA Biosynthetic Process Protein Localization To Plasma Membrane Protein-membrane Adaptor Activity Protein Localization To Cell Periphery Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Microtubule Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis
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