TBC1D10A and EZR

Number of citations of the paper that reports this interaction (PubMedID 11285285)
70

Data Source:
HPRD (in vitro, in vivo)

		TBC1D10A	EZR
Description		TBC1 domain family member 10A	ezrin
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Microvillus Cell Projection Extracellular Exosome	Fibrillar Center Ruffle Immunological Synapse Uropod Extracellular Space Cytoplasm Endosome Cytosol Cytoskeleton Actin Filament Plasma Membrane Microvillus Brush Border Adherens Junction Focal Adhesion Cell Cortex Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Cortical Cytoskeleton Microvillus Membrane Vesicle Ruffle Membrane Protein-containing Complex Ciliary Basal Body Cell Projection Plasma Membrane Raft Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding PDZ Domain Binding Cadherin Binding	RNA Binding Actin Binding Protein Binding Microtubule Binding Cytoskeletal Protein Binding Protein Domain Specific Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding S100 Protein Binding Cadherin Binding Cell Adhesion Molecule Binding Actin Filament Binding Protein Kinase A Binding ATPase Binding Disordered Domain Specific Binding
	Biological Process	Retrograde Transport, Endosome To Golgi Positive Regulation Of Proteolysis Regulation Of Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Intestinal D-glucose Absorption Sphingosine-1-phosphate Receptor Signaling Pathway Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Positive Regulation Of Gene Expression Protein Kinase A Signaling Gland Morphogenesis Membrane To Membrane Docking Microvillus Assembly Actin Cytoskeleton Organization Astral Microtubule Organization Protein-containing Complex Localization Receptor Internalization Regulation Of Microvillus Length Negative Regulation Of Interleukin-2 Production Regulation Of Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Positive Regulation Of Multicellular Organism Growth Cortical Microtubule Organization Establishment Of Epithelial Cell Apical/basal Polarity Positive Regulation Of Protein Catabolic Process Filopodium Assembly Negative Regulation Of T Cell Receptor Signaling Pathway Actin Filament Bundle Assembly Establishment Of Centrosome Localization Establishment Of Endothelial Barrier Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To CAMP Protein Localization To Plasma Membrane Protein Localization To Cell Cortex Postsynaptic Actin Cytoskeleton Organization Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of Organelle Assembly Terminal Web Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of P38MAPK Cascade Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		TBC/RABGAPs	Netrin-1 signaling Recycling pathway of L1 Recycling pathway of L1 Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Delirium ( 29631748) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)	Bladder cancer (smoking interaction) ( 24662972) Blond vs. brown/black hair color ( 30531825) Brown vs. black hair color ( 30531825) Hair color ( 29662168) Refractive error ( 32231278)
Interacting Genes		9 interacting genes: ACD EZR GABARAPL1 MAP1LC3A NHERF1 NHERF2 TERF1 TERF2IP TEX13A	57 interacting genes: ACTB ACTC1 ADORA2B ADRA1B ARF6 ARHGDIB CD44 CDH1 CDK5 CEBPA CFTR CLIC5 CTNNB1 DLG1 EGFR ERBB3 FAS FASLG GZMM ICAM1 ICAM2 ICAM3 IQGAP1 L1CAM LCK MDM2 MME MPP3 MSN NF2 NHERF1 NHERF2 PALLD PIK3R1 PRKAR2A PRKCA PTK2 PTPRC RDX ROCK1 RSPH1 S100P SCYL3 SDC2 SELL SELP SLC26A4-AS1 SPN SUMO2 TBC1D10A TMEM8B TSC1 USP1 VCAM1 VPS11 WFDC1 WWOX
Entrez ID		83874	7430
HPRD ID		18162	00475
Ensembl ID		ENSG00000099992	ENSG00000092820
Uniprot IDs		A7E244 B7ZVY9 Q9BXI6	P15311
PDB IDs			1NI2 4RM8 4RM9 4RMA 7T1K 7T1L
Enriched GO Terms of Interacting Partners?		Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Type 2 Metabotropic Glutamate Receptor Binding Telomeric DNA Binding Telomere Maintenance Via Telomere Lengthening Type 3 Metabotropic Glutamate Receptor Binding Negative Regulation Of Telomere Maintenance Phosphatase Binding Regulation Of Establishment Of Protein Localization To Telomere Regulation Of Establishment Of Protein Localization To Chromosome Microvillus Assembly Protection From Non-homologous End Joining At Telomere Positive Regulation Of Telomere Maintenance Microvillus Organization Negative Regulation Of Chromosome Organization DNA Biosynthetic Process G-rich Strand Telomeric DNA Binding Cellular Response To Nitrogen Starvation Protein Localization To Chromosome, Telomeric Region Telomere Maintenance Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Phosphatidylethanolamine Binding Telomere Maintenance In Response To DNA Damage Cellular Component Assembly Telomere Organization Establishment Of Epithelial Cell Apical/basal Polarity Negative Regulation Of DNA Metabolic Process Organelle Organization Negative Regulation Of Telomere Maintenance Via Telomerase Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Chromosome, Telomeric Region Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Microvillus Membrane Gland Morphogenesis Establishment Of Epithelial Cell Polarity Negative Regulation Of DNA Biosynthetic Process Protein Localization To Plasma Membrane Protein-membrane Adaptor Activity Protein Localization To Cell Periphery Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomerase Microtubule Binding Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity	Plasma Membrane Cell Adhesion Cell-cell Adhesion Focal Adhesion Leukocyte Cell-cell Adhesion Cell Migration Cell Motility Microvillus Regulation Of Intracellular Signal Transduction Lamellipodium Extracellular Exosome Membrane Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Adhesion Membrane To Membrane Docking Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Tethering Or Rolling Regulation Of Multicellular Organismal Process Response To Growth Factor Positive Regulation Of Transport Regulation Of Cell-cell Adhesion Filopodium Regulation Of Developmental Process Regulation Of Cell Migration Cell Projection Regulation Of Signal Transduction Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Localization Regulation Of Apoptotic Process Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Component Organization Positive Regulation Of Signal Transduction Membrane Docking Cell Surface Cellular Developmental Process Regulation Of Vesicle-mediated Transport Regulation Of Cell Motility Regulation Of Programmed Cell Death Apical Plasma Membrane Integrin Binding Developmental Process Regulation Of Locomotion Cell-substrate Adhesion T Cell Activation Cell-matrix Adhesion Ruffle
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