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KRTAP4-12 and SPRY2
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid, two hybrid)
HPRD
(two hybrid)
KRTAP4-12
SPRY2
Description
keratin associated protein 4-12
sprouty RTK signaling antagonist 2
Image
No pdb structure
GO Annotations
Cellular Component
Cytosol
Intermediate Filament
Keratin Filament
Nucleus
Cytoplasm
Cytosol
Cytoskeleton
Microtubule
Plasma Membrane
Actin Cytoskeleton
Microtubule Cytoskeleton
Membrane
Ruffle Membrane
Cell Projection
Microtubule End
Molecular Function
Protein Binding
Protein Binding
Protein Kinase Binding
Protein Serine/threonine Kinase Inhibitor Activity
Protein Serine/threonine Kinase Activator Activity
Ubiquitin-protein Transferase Inhibitor Activity
Molecular Function Inhibitor Activity
Biological Process
Hair Cycle
Establishment Of Mitotic Spindle Orientation
Sensory Perception Of Sound
Negative Regulation Of Cell Population Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Regulation Of Signal Transduction
Positive Regulation Of Gene Expression
Negative Regulation Of Epithelial To Mesenchymal Transition
Negative Regulation Of Angiogenesis
Lung Development
Positive Regulation Of Cell Migration
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Negative Regulation Of Cell Projection Organization
Negative Regulation Of Protein Ubiquitination
Positive Regulation Of Peptidyl-serine Phosphorylation
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Cell Fate Commitment
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of Ras Protein Signal Transduction
Animal Organ Development
Branching Morphogenesis Of An Epithelial Tube
Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway
Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction
Lung Morphogenesis
Lung Growth
Bud Elongation Involved In Lung Branching
Respiratory System Development
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Lens Fiber Cell Differentiation
Cellular Response To Leukemia Inhibitory Factor
Pathways
Spry regulation of FGF signaling
EGFR downregulation
Drugs
Diseases
GWAS
Adiposity (
21706003
)
Adventurousness (
30643258
)
Body fat percentage (
26833246
)
Central corneal thickness (
32528159
)
Diastolic blood pressure (
30224653
)
Fasting blood insulin (BMI interaction) (
22581228
)
General risk tolerance (MTAG) (
30643258
)
Height (
25282103
31562340
)
Insulin-related traits (multivariate analysis) (
32002517
)
Lactose tolerance test (
31791255
)
Leisure-time exercise behaviour (age-stratified) (
30102679
)
Medication use (drugs used in diabetes) (
31015401
)
Methadone dose in opioid dependence (
28115739
)
Nonsyndromic cleft lip with cleft palate (
28232668
)
Orofacial clefts (
20023658
22863734
)
Response to inhaled corticosteroid treatment in asthma (change in FEV1) (
24792382
)
Sleep duration (
25469926
)
Thrombocytopenia in coronary artery bypass surgery (
30103242
)
Type 2 diabetes (
29358691
30718926
32499647
31118516
30297969
30054458
28869590
26818947
24509480
22885922
20862305
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Interacting Genes
160 interacting genes:
ADAM12
ADAMTSL4
ALPP
AQP1
ATG12
ATN1
AXIN1
BAG4
BAHD1
BEX2
C10orf62
CATSPER1
CBX2
CCDC116
CCDC185
CCNK
CDC42EP1
CDX2
CHCHD3
CHIC2
CHRD
CLCNKA
CLDN2
CNNM3
CNTFR
COL8A1
CRCT1
CREB5
CRY1
CYSRT1
DBF4B
DLK2
EIF4E2
ELOA2
FAM107A
FAM27E3
FAM76B
FBXL18
FBXO34
FBXW5
FCHO1
FUCA2
GLRX3
GNE
GPATCH2L
GPRIN2
GRAP2
HHEX
HOXA1
HOXB9
IFI30
IGSF8
ILF3
KRT31
KRTAP1-1
KRTAP1-3
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP19-2
KRTAP2-3
KRTAP2-4
KRTAP26-1
KRTAP3-1
KRTAP3-2
KRTAP4-2
KRTAP4-4
KRTAP5-1
KRTAP5-3
KRTAP5-4
KRTAP5-6
KRTAP5-7
KRTAP5-9
KRTAP6-2
KRTAP9-2
KRTAP9-3
LCE1A
LCE1B
LCE1C
LCE1D
LCE1E
LCE1F
LCE2A
LCE2B
LCE2C
LCE2D
LCE3A
LCE3B
LCE3C
LCE3D
LCE3E
LCE4A
LCE5A
LELP1
LINGO1
LNX1
MAPKBP1
MEOX2
MRPL4
NBPF19
NOTCH2NLA
NPDC1
NUDT18
NUFIP2
OTX1
PCSK5
PDGFRB
PFKL
PHLDA1
PLSCR1
PLSCR4
PNKP
POU4F2
PRKAB2
PRKAG1
PRR13
PTPMT1
QPRT
R3HDM2
RERE
RPS28
SHFL
SLC25A10
SLC25A6
SMCP
SPATA3
SPG7
SPRY1
SPRY2
TAP1
TBC1D16
TBC1D23
TGM1
THAP10
THAP7
TOP3B
TXNDC5
ZBTB16
ZNF165
ZNF20
ZNF250
ZNF408
ZNF414
ZNF415
ZNF417
ZNF426
ZNF439
ZNF440
ZNF497
ZNF581
ZNF638
ZNF655
ZNF696
ZNF764
ZNF837
ZSCAN26
110 interacting genes:
ADAMTSL4
AQP1
ATRIP
BAG3
BRAF
CATSPER1
CBL
CBLB
CBLC
CHRD
CHRNG
CREB5
CRIP2
CRMP1
CSTB
CTSB
DGCR6
DNM2
DSCR9
DYRK1A
EIF4E2
FAIM
FAM219A
FBN1
FBXO7
FRS3
FXR1
FXR2
GNE
GP9
GPRIN2
GRAP2
GRB2
GRN
HEXIM2
HNRNPLL
HOXA1
HSD3B7
ITSN1
KDM1A
KIF1A
KRTAP10-1
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-7
KRTAP5-6
KRTAP5-9
KRTAP9-2
KRTAP9-4
LASP1
LCE1A
LCE1B
LCE1C
LCE1F
LCE2D
LCE3C
LCE3E
LCE4A
LONRF1
MAPKBP1
MB21D2
MDFI
MEOX2
MID2
MKNK1
MLLT6
NCK2
NEDD4
NR1H2
NUBP1
NUFIP2
OTX1
PACSIN3
PLSCR1
PRKAB2
PRKCD
PRKD1
PTGER3
PTPN11
RAF1
RTF2
RUNX1T1
SDHB
SEMA5B
SH3KBP1
SHFL
SIAH2
SPRY1
STK16
TCAF1
TMEM14B
TNS2
TRAF2
TRIM51
TXNDC5
UBASH3A
UBASH3B
UBR1
USP20
VPS25
VPS36
ZBTB16
ZNF266
ZNF417
ZNF587
Entrez ID
83755
10253
HPRD ID
13941
03916
Ensembl ID
ENSG00000213416
ENSG00000136158
Uniprot IDs
Q9BQ66
O43597
PDB IDs
3BUM
3OB1
5HKY
5HKZ
5HL0
Enriched GO Terms of Interacting Partners
?
Intermediate Filament
Keratinization
Keratin Filament
Epidermis Development
Protein Binding
Tissue Development
Identical Protein Binding
Intermediate Filament
Keratin Filament
Keratinization
Phosphotyrosine Residue Binding
Identical Protein Binding
Epidermis Development
Negative Regulation Of Signal Transduction
Negative Regulation Of Cell Communication
Negative Regulation Of Signaling
Protein Binding
Cytosol
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Receptor Tyrosine Kinase Binding
SH3 Domain Binding
Regulation Of Signal Transduction
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
ESCRT II Complex
ERBB Signaling Pathway
Tissue Development
Ubiquitin-protein Transferase Activity
Regulation Of Cell Activation
Regulation Of Biological Quality
Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway
Zinc Ion Binding
Ubiquitin Protein Ligase Activity
Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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