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KRTAP4-12 and PDGFRB
Number of citations of the paper that reports this interaction (PMID
16189514
)
699
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
KRTAP4-12
PDGFRB
Gene Name
keratin associated protein 4-12
platelet-derived growth factor receptor, beta polypeptide
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Keratin Filament
Nucleus
Cytoplasm
Plasma Membrane
Focal Adhesion
Cell Surface
Membrane
Integral Component Of Membrane
Cytoplasmic Membrane-bounded Vesicle
Apical Plasma Membrane
Intrinsic Component Of Plasma Membrane
Lysosomal Lumen
Extracellular Vesicular Exosome
Molecular Function
Protein Binding
Protein Tyrosine Kinase Activity
Platelet Activating Factor Receptor Activity
Platelet-derived Growth Factor-activated Receptor Activity
Platelet-derived Growth Factor Beta-receptor Activity
Receptor Binding
Platelet-derived Growth Factor Receptor Binding
Protein Binding
ATP Binding
Protein Kinase Binding
Vascular Endothelial Growth Factor Binding
Phosphatidylinositol 3-kinase Binding
Platelet-derived Growth Factor Binding
Biological Process
In Utero Embryonic Development
Tissue Homeostasis
Glycosaminoglycan Biosynthetic Process
Signal Transduction
Epidermal Growth Factor Receptor Signaling Pathway
G-protein Coupled Receptor Signaling Pathway
Positive Regulation Of Cell Proliferation
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Toxic Substance
Positive Regulation Of Phospholipase C Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Smooth Muscle Cell Migration
Cell Migration
Peptidyl-tyrosine Phosphorylation
Adrenal Gland Development
Positive Regulation Of Cell Migration
Response To Estradiol
Positive Regulation Of Phosphoprotein Phosphatase Activity
Response To Retinoic Acid
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Collagen Biosynthetic Process
Response To Fluid Shear Stress
Cell Migration Involved In Vasculogenesis
Metanephric Mesenchymal Cell Migration
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Positive Regulation Of Metanephric Mesenchymal Cell Migration By Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Aorta Morphogenesis
Cellular Response To Platelet-derived Growth Factor Stimulus
Positive Regulation Of Cell Proliferation By VEGF-activated Platelet Derived Growth Factor Receptor Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Wound Healing
Response To Hydrogen Peroxide
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Mitotic Nuclear Division
Phosphatidylinositol Metabolic Process
Protein Autophosphorylation
Platelet-derived Growth Factor Receptor Signaling Pathway
Neurotrophin TRK Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
Positive Regulation Of Smooth Muscle Cell Proliferation
Skeletal System Morphogenesis
Smooth Muscle Tissue Development
Inner Ear Development
Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Chemotaxis
Cardiac Myofibril Assembly
Response To Hyperoxia
Cell Chemotaxis
Cell Migration Involved In Coronary Angiogenesis
Retina Vasculature Development In Camera-type Eye
Positive Regulation Of ERK1 And ERK2 Cascade
Smooth Muscle Cell Chemotaxis
Metanephric Mesenchyme Development
Metanephric Glomerular Mesangial Cell Proliferation Involved In Metanephros Development
Metanephric Glomerular Capillary Formation
Metanephric Comma-shaped Body Morphogenesis
Metanephric S-shaped Body Morphogenesis
Positive Regulation Of Calcium Ion Import
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Positive Regulation Of DNA Biosynthetic Process
Pathways
Signaling by the B Cell Receptor (BCR)
Signaling by FGFR in disease
PIP3 activates AKT signaling
Signaling by EGFRvIII in Cancer
Signaling by SCF-KIT
Downstream signaling events of B Cell Receptor (BCR)
DAP12 signaling
PI3K/AKT activation
PI-3K cascade
PI3K events in ERBB2 signaling
Downstream signaling of activated FGFR
Innate Immune System
Signaling by PDGF
Signalling by NGF
DAP12 interactions
GAB1 signalosome
Signaling by Ligand-Responsive EGFR Variants in Cancer
NGF signalling via TRKA from the plasma membrane
Signaling by Overexpressed Wild-Type EGFR in Cancer
Signaling by ERBB4
Role of LAT2/NTAL/LAB on calcium mobilization
Constitutive PI3K/AKT Signaling in Cancer
PI3K events in ERBB4 signaling
Signaling by FGFR
Signaling by ERBB2
Signaling by EGFR
Downstream signal transduction
Fc epsilon receptor (FCERI) signaling
Signaling by EGFR in Cancer
PI3K/AKT Signaling in Cancer
Adaptive Immune System
Drugs
Becaplermin
Sorafenib
Imatinib
Dasatinib
Sunitinib
Pazopanib
Regorafenib
Diseases
GWAS
Protein-Protein Interactions
107 interactors:
ADAMTSL4
ALPP
AQP1
ATG12
ATN1
BAHD1
BEX2
C10orf62
C19orf66
CATSPER1
CBX2
CCDC116
CCDC185
CCNK
CDC42EP1
CHCHD3
CHIC2
CLDN2
CNNM3
CNTFR
COL8A1
CRCT1
CREB5
CRY1
DBF4B
DLK2
EIF4E2
FAM107A
FAM27E3
FAM76B
FBXL18
FBXW5
GLRX3
GNE
GPATCH2L
GPRIN2
GRAP2
HHEX
HOXA1
HOXB9
IFI30
ILF3
KRTAP10-1
KRTAP10-3
KRTAP10-5
KRTAP10-8
KRTAP10-9
KRTAP26-1
KRTAP3-2
KRTAP5-6
KRTAP5-9
KRTAP9-2
LCE1B
LCE2D
LCE3E
LCE4A
LINGO1
LNX1
MAPKBP1
MEOX2
MRPL4
NOTCH2NL
NPDC1
NUDT18
NUFIP2
OTX1
PCSK5
PDGFRB
PFKL
PHLDA1
PLSCR1
PLSCR4
PNKP
PRKAB2
PRR13
QPRT
RERE
RPS28
SLC25A10
SLC25A6
SMCP
SPATA3
SPG7
SPRY2
TAP1
TBC1D16
TBC1D23
TCEB3B
THAP10
THAP7
TOP3B
TXNDC5
ZBTB16
ZNF165
ZNF20
ZNF250
ZNF408
ZNF415
ZNF417
ZNF426
ZNF439
ZNF440
ZNF581
ZNF638
ZNF655
ZNF764
ZSCAN26
59 interactors:
ARAF
BAG1
CAV1
CAV3
CBL
COPA
COPB1
CRK
EGFR
EIF2AK2
FYN
GAB1
GRB10
GRB14
GRB2
GRB7
ITGB3
JAK1
JAK2
KLHL12
KRTAP4-12
NCK1
NCK2
NEDD4
PDAP1
PDGFB
PDGFD
PDGFRA
PIK3C2B
PIK3CA
PIK3R1
PIK3R2
PIK3R3
PLCG1
PRDX2
PTK2
PTPN1
PTPN11
PTPN2
PTPRJ
RAF1
RASA1
S1PR1
SHC1
SLC9A3R1
SNX1
SNX2
SNX4
SOCS1
SRC
STAT1
STAT3
STAT5A
STAT5B
SYNGAP1
TRIP6
TYK2
VAV1
YES1
Entrez ID
83755
5159
HPRD ID
13941
01423
Ensembl ID
ENSG00000213416
ENSG00000113721
Uniprot IDs
Q9BQ66
P09619
Q59F04
PDB IDs
1GQ5
1H9O
1LWP
2L6W
2PLD
2PLE
3MJG
Enriched GO Terms of Interacting Partners
?
Macromolecule Biosynthetic Process
Cellular Macromolecule Biosynthetic Process
RNA Biosynthetic Process
Transcription, DNA-templated
Biosynthetic Process
Gene Expression
RNA Metabolic Process
Nucleobase-containing Compound Metabolic Process
Cellular Nitrogen Compound Metabolic Process
Heterocycle Metabolic Process
Cellular Aromatic Compound Metabolic Process
Nitrogen Compound Metabolic Process
Regulation Of Gene Expression
Regulation Of Transcription, DNA-templated
Regulation Of Nitrogen Compound Metabolic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Cellular Metabolic Process
Regulation Of RNA Metabolic Process
Keratinization
Anterior/posterior Pattern Specification
Regulation Of Cellular Process
Regulation Of Metabolic Process
Cellular Process
Keratinocyte Differentiation
Embryo Development
Phospholipid Scrambling
Metanephric Glomerulus Vasculature Development
Pattern Specification Process
Metanephric Glomerulus Development
Epidermal Cell Differentiation
Epidermis Development
Mitochondrion Organization
Metabolic Process
Forebrain Morphogenesis
Transcription From RNA Polymerase II Promoter
Glomerulus Vasculature Development
Multicellular Organismal Development
Organic Anion Transport
Inner Ear Development
Cell Migration Involved In Coronary Angiogenesis
Hepatic Duct Development
Abducens Nerve Formation
Metanephric Mesenchymal Cell Migration
Transepithelial Water Transport
Renin Secretion Into Blood Stream
Metanephric Descending Thin Limb Development
DGDP Catabolic Process
Metanephric Proximal Straight Tubule Development
Metanephric Proximal Convoluted Tubule Segment 2 Development
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Enzyme Linked Receptor Protein Signaling Pathway
Cellular Response To Organonitrogen Compound
Cellular Response To Peptide Hormone Stimulus
Cellular Response To Peptide
Regulation Of Signal Transduction
Regulation Of Signaling
Epidermal Growth Factor Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
ERBB Signaling Pathway
Regulation Of Phosphorylation
Regulation Of Body Fluid Levels
Regulation Of Immune System Process
Response To Peptide Hormone
Signal Transduction
Regulation Of Immune Response
Response To Peptide
Blood Coagulation
Hemostasis
Regulation Of Phosphorus Metabolic Process
Signaling
Cell Communication
Innate Immune Response
Response To Organonitrogen Compound
Cellular Response To Hormone Stimulus
Regulation Of Kinase Activity
Wound Healing
Immune System Process
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Cellular Response To Organic Substance
Fc Receptor Signaling Pathway
Cellular Response To Stimulus
Regulation Of Intracellular Signal Transduction
Locomotion
Positive Regulation Of Signal Transduction
Response To Wounding
Cell Migration
Fibroblast Growth Factor Receptor Signaling Pathway
Response To Hormone
Neurotrophin TRK Receptor Signaling Pathway
Defense Response
Neurotrophin Signaling Pathway
Leukocyte Migration
Cell Motility
Cellular Response To Fibroblast Growth Factor Stimulus
Response To Fibroblast Growth Factor
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response
Regulation Of Protein Phosphorylation
Response To Organic Substance
Tagcloud
?
14q32
5q31
5q33
apart
apl
aspirate
break
complication
cytogenetic
cytogenetics
exon
firstly
fusion
infrequent
kiaa1509
myeloid
neoplasm
neoplasms
partner
promyelocytic
q32
q33
rara
rarely
rearrangement
rt
trip11
undetectable
xy
Tagcloud (Difference)
?
14q32
5q31
5q33
apart
apl
aspirate
break
complication
cytogenetic
cytogenetics
exon
firstly
fusion
infrequent
kiaa1509
myeloid
neoplasm
neoplasms
partner
promyelocytic
q32
q33
rara
rarely
rearrangement
rt
trip11
undetectable
xy
Tagcloud (Intersection)
?