ERAP1

Description		endoplasmic reticulum aminopeptidase 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Extracellular Exosome
	Molecular Function	Endopeptidase Activity Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Peptidase Activity Metalloexopeptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process	Angiogenesis Adaptive Immune Response Immune System Process Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Peptide Antigen Assembly With MHC Class I Protein Complex Proteolysis Membrane Protein Ectodomain Proteolysis Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Peptide Catabolic Process Regulation Of Innate Immune Response Fat Cell Differentiation Positive Regulation Of Angiogenesis
Pathways		Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Acute anterior uveitis in ankylosing spondylitis ( 32492107 25200001) Alcohol dependence ( 19581569) Ankylosing spondylitis ( 20062062 30946743 23749187 21743469) Behcet's disease ( 23291587) Birdshot chorioretinopathy ( 24957906) Blood protein levels ( 30072576) Body mass index ( 26426971 29273807) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Colorectal cancer ( 25990418) Emotional lability in attention deficit hyperactivity disorder ( 31085060) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Inflammatory skin disease ( 25574825) Medication use (calcium channel blockers) ( 31015401) Psoriasis ( 20953190 25854761 25574825 23143594) Psoriasis vulgaris ( 26626624) Systolic blood pressure ( 30578418) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		4 interacting genes: H3-4 IL6R TNFRSF1A WEE2-AS1
Entrez ID		51752
HPRD ID		06015
Ensembl ID		ENSG00000164307
Uniprot IDs		A0A075BTL2 Q9NZ08
PDB IDs		2YD0 3MDJ 3QNF 3RJO 5J5E 6M8P 6MGQ 6Q4R 6RQX 6RYF 6T6R 7MWB 7MWC 7Z28 9GJN 9GJS 9GK6 9GKE
Enriched GO Terms of Interacting Partners?		Extrinsic Apoptotic Signaling Pathway Ciliary Neurotrophic Factor Receptor Activity Hepatic Immune Response Receptor Complex Ciliary Neurotrophic Factor Binding Interleukin-6 Receptor Complex Interleukin-11 Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Cell Surface Receptor Signaling Pathway Via STAT Cell Surface Receptor Signaling Pathway Via JAK-STAT Ciliary Neurotrophic Factor Receptor Complex Interleukin-11 Binding Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Spermatogonial Cell Division Pre-mRNA 5'-splice Site Binding Interleukin-11-mediated Signaling Pathway Defense Response To Bacterium Interleukin-6 Receptor Binding Positive Regulation Of Glomerular Mesangial Cell Proliferation Ciliary Neurotrophic Factor-mediated Signaling Pathway Vascular Endothelial Growth Factor Production Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Positive Regulation Of Apoptotic Process Involved In Morphogenesis Aortic Valve Development Tumor Necrosis Factor Binding Semi-lunar Valve Development DNA Replication-dependent Chromatin Assembly MRNA 5'-splice Site Recognition Positive Regulation Of Cell Proliferation Involved In Kidney Development Apoptotic Signaling Pathway Tumor Necrosis Factor Receptor Activity Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet Aggregation Regulation Of Cell Differentiation Negative Regulation Of Collagen Biosynthetic Process Cytokine-mediated Signaling Pathway Response To Bacterium T-helper 17 Cell Lineage Commitment Interleukin-6-mediated Signaling Pathway T-helper Cell Lineage Commitment Endocrine Pancreas Development Regulation Of Establishment Of Endothelial Barrier Positive Regulation Of Homotypic Cell-cell Adhesion U1 SnRNP Regulation Of Membrane Lipid Metabolic Process CD4-positive, Alpha-beta T Cell Lineage Commitment
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