ERAP1

Gene Name		endoplasmic reticulum aminopeptidase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Metalloexopeptidase Activity Zinc Ion Binding
	Biological Process	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Membrane Protein Ectodomain Proteolysis Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Innate Immune Response Fat Cell Differentiation Positive Regulation Of Angiogenesis
Pathways		Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Adaptive Immune System
Drugs
Diseases
GWAS		Alcohol dependence ( 19581569) Ankylosing spondylitis ( 21743469 20062062) Behcet's disease ( 23291587) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190)
Protein-protein Interactions		3 interactors: HIST3H3 IL6R TNFRSF1A
Entrez ID		51752
HPRD ID		06015
Ensembl ID		ENSG00000164307
Uniprot IDs		Q9NZ08
PDB IDs		2YD0 3MDJ 3QNF 3RJO
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of JAK-STAT Cascade Regulation Of Interleukin-6 Production Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Bacterium Negative Regulation Of Cytokine Production Regulation Of Peptidyl-tyrosine Phosphorylation Hepatic Immune Response Apoptotic Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Activation Of Janus Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Collagen Biosynthetic Process Inflammatory Response Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Cytokine-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Metabolic Process Response To Bacterium Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Cytokine Production Negative Regulation Of Interleukin-8 Production Interleukin-6-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Monocyte Chemotaxis Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Estradiol Stimulus Neutrophil Mediated Immunity Response To Cytokine Response To Other Organism Positive Regulation Of Protein Phosphorylation Response To Biotic Stimulus Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Positive Regulation Of Intracellular Signal Transduction Cellular Response To Estrogen Stimulus Prostaglandin Metabolic Process Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Phosphorylation Response To Interleukin-6 Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Defense Response To Gram-negative Bacterium Negative Regulation Of Interleukin-6 Production Regulation Of Collagen Metabolic Process Apoptotic Process
Tagcloud ?		ad5 adenovirus ag aminopeptidase augmented autoimmune basel behind chemokine endoplasmic genetically herein hpbmcs identifying inflammasome innate internalization investigating karger modulating mononuclear nlrp3 polymorphic pyrin reticulum secreted unexpectedly variants vectors