ERAP1 and TNFRSF1A

Number of citations of the paper that reports this interaction (PMID 12189246)
35

Data Source:
HPRD (in vivo)

		ERAP1	TNFRSF1A
Gene Name		endoplasmic reticulum aminopeptidase 1	tumor necrosis factor receptor superfamily, member 1A
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Golgi Membrane Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Receptor Complex Membrane Raft Synapse
	Molecular Function	Aminopeptidase Activity Interleukin-6 Receptor Binding Interleukin-1, Type II Receptor Binding Protein Binding Metalloexopeptidase Activity Zinc Ion Binding	Protease Binding Tumor Necrosis Factor-activated Receptor Activity Protein Binding Protein Complex Binding Tumor Necrosis Factor Binding
	Biological Process	Angiogenesis Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Membrane Protein Ectodomain Proteolysis Regulation Of Blood Pressure Response To Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Regulation Of Innate Immune Response Fat Cell Differentiation Positive Regulation Of Angiogenesis	Response To Hypoxia Prostaglandin Metabolic Process Inflammatory Response Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Wounding Negative Regulation Of Gene Expression Viral Process Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide Negative Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Tetrapyrrole Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Defense Response To Bacterium Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Amino Acid Response To Alkaloid Positive Regulation Of Neuron Apoptotic Process Response To Ethanol Positive Regulation Of Angiogenesis Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Protein Heterooligomerization Cellular Response To Mechanical Stimulus Cellular Response To Estradiol Stimulus Apoptotic Signaling Pathway
Pathways		Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Adaptive Immune System	TNF signaling Death Receptor Signalling Programmed Cell Death Extrinsic Pathway
Drugs			6-[3-(4-Morpholinyl)Propyl]-2-(3-Nitrophenyl)-5-Thioxo-5,6,-Dihydro-7h-Thienol[2\',3\':4,5]Pyrrolo[1,2-C]Imidazol-7-One
Diseases
GWAS		Alcohol dependence ( 19581569) Ankylosing spondylitis ( 21743469 20062062) Behcet's disease ( 23291587) Hodgkin's lymphoma ( 22286212) Inflammatory bowel disease ( 23128233) Psoriasis ( 20953190)	Adverse response to chemotherapy (neutropenia/leucopenia) (all anthracycline-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (epirubicin) ( 23648065) Multiple sclerosis ( 19525953 21833088) Primary biliary cirrhosis ( 21399635)
Protein-Protein Interactions		3 interactors: HIST3H3 IL6R TNFRSF1A	60 interactors: ADAM17 ATF6 BAG4 BCL10 CASP10 CASP7 CHUK CLIP3 DAPK1 DAXX ERAP1 ERN1 FANCD2 GNB2L1 GRB2 GYS2 HRG HSP90AA1 HSPA8 IKBKB IKBKG JAK1 JAK2 LTA LTB MADD MAGEH1 MAPK1 MOAP1 MYOC NSMAF PIP4K2B PRDX3 PRKCD PSMD2 PTK2 PTPN11 PTPN6 RASSF1 RIPK1 RIPK2 RIPK3 SGTA SRC STAMBP STAT1 SUMO1 SYK TNF TNFRSF25 TNFSF13 TRADD TRAF1 TRAF2 TRAF3 TRAP1 TRPC4AP UBE2I UBQLN1 UCHL1
Entrez ID		51752	7132
HPRD ID		06015	01861
Ensembl ID		ENSG00000164307	ENSG00000067182
Uniprot IDs		Q9NZ08	J9PH39 P19438
PDB IDs		2YD0 3MDJ 3QNF 3RJO	1EXT 1FT4 1ICH 1NCF 1TNR
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of JAK-STAT Cascade Regulation Of JAK-STAT Cascade Regulation Of Interleukin-6 Production Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Bacterium Negative Regulation Of Cytokine Production Regulation Of Peptidyl-tyrosine Phosphorylation Hepatic Immune Response Apoptotic Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Cytokine Production Positive Regulation Of Activation Of Janus Kinase Activity Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Collagen Biosynthetic Process Inflammatory Response Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Cytokine-mediated Signaling Pathway Negative Regulation Of Multicellular Organismal Metabolic Process Response To Bacterium Regulation Of Cellular Ketone Metabolic Process Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Cytokine Production Negative Regulation Of Interleukin-8 Production Interleukin-6-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Monocyte Chemotaxis Regulation Of Protein Import Into Nucleus, Translocation Cellular Response To Estradiol Stimulus Neutrophil Mediated Immunity Response To Cytokine Response To Other Organism Positive Regulation Of Protein Phosphorylation Response To Biotic Stimulus Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Positive Regulation Of Intracellular Signal Transduction Cellular Response To Estrogen Stimulus Prostaglandin Metabolic Process Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Phosphorylation Response To Interleukin-6 Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Modification Process Defense Response To Gram-negative Bacterium Negative Regulation Of Interleukin-6 Production Regulation Of Collagen Metabolic Process Apoptotic Process	Apoptotic Process Regulation Of Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Regulation Of Signal Transduction Regulation Of Immune Response Positive Regulation Of Signal Transduction Positive Regulation Of Protein Metabolic Process Regulation Of Signaling Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Innate Immune Response Innate Immune Response Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Stimulus Cellular Response To Stimulus Positive Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Regulation Of Intracellular Signal Transduction Cell Communication Regulation Of Phosphorus Metabolic Process Defense Response Positive Regulation Of Immune Response Immune System Process Signal Transduction Positive Regulation Of Metabolic Process Intracellular Signal Transduction Signaling Regulation Of Kinase Activity Positive Regulation Of Immune System Process Regulation Of Protein Phosphorylation Response To Organic Substance Regulation Of Protein Kinase Activity Regulation Of Catalytic Activity Immune Response-regulating Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Response To Cytokine Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Phosphorylation
Tagcloud ?		ad5 adenovirus ag aminopeptidase augmented autoimmune basel behind chemokine endoplasmic genetically herein hpbmcs identifying inflammasome innate internalization investigating karger modulating mononuclear nlrp3 polymorphic pyrin reticulum secreted unexpectedly variants vectors	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Difference) ?		ad5 adenovirus ag aminopeptidase augmented autoimmune basel behind chemokine endoplasmic genetically herein hpbmcs identifying inflammasome innate internalization investigating karger modulating mononuclear nlrp3 polymorphic pyrin reticulum secreted unexpectedly variants vectors	casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fas fasl faslg fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr2 viable
Tagcloud (Intersection) ?