FOXA1 and SEZ6L2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		FOXA1	SEZ6L2
Description		forkhead box A1	seizure related 6 homolog like 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Microvillus	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Neuronal Cell Body
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Smoothened Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Dorsal/ventral Neural Tube Patterning Cell Differentiation Neuron Differentiation Lung Development Response To Estradiol Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Tube Morphogenesis Hormone Metabolic Process Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Specification Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Lung Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Alveolar Secondary Septum Development Connective Tissue Development Dopaminergic Neuron Differentiation Respiratory Basal Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Adult Locomotory Behavior Cerebellar Purkinje Cell Layer Development Synapse Maturation
Pathways		Estrogen-dependent gene expression Formation of axial mesoderm
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergy ( 27182965) Chromium levels ( 26025379) Coronary artery aneurysm in Kawasaki disease ( 26434682) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Intraocular pressure ( 29617998) Periodontitis (CDC/AAP) ( 24024966) Self-reported allergy ( 23817569) Tonsillectomy ( 27182965 28928442)	Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Anthropometric traits ( 19260139) Autism spectrum disorder or schizophrenia ( 28540026) Bitter alcoholic beverage consumption ( 31046077) Body fat distribution (arm fat ratio) ( 30664634) Response to taxane treatment (paclitaxel) ( 23006423) Schizophrenia ( 25056061 28991256 29483656) Systemic lupus erythematosus ( 23273568)
Interacting Genes		6 interacting genes: AR H3-4 NKX2-1 ONECUT1 SEZ6L2 TLE1	7 interacting genes: ETV5 FOXA1 MTDH OASL TK1 TOX3 UNG
Entrez ID		3169	26470
HPRD ID		03801	06686
Ensembl ID		ENSG00000129514	ENSG00000174938
Uniprot IDs		P55317	A0A087WYL5 A0A0A8K8P7 B7Z5L4 Q6UXD5
PDB IDs		7VOX 8VFY 8VFZ 8VG1 8VG2
Enriched GO Terms of Interacting Partners?		Leydig Cell Differentiation Developmental Induction Endoderm Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Signal Transduction Prostate Induction Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Animal Organ Morphogenesis Negative Regulation Of Cell Communication Anatomical Structure Morphogenesis Epithelial Cell Differentiation Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signaling Pancreatic D Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Globus Pallidus Development Club Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Spermatogonial Cell Division Androgen Binding DNA-binding Transcription Factor Activity Pancreatic A Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Forebrain Dorsal/ventral Pattern Formation Cell Fate Commitment RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Prostatic Bud Formation Locomotory Behavior Lung Saccule Development RNA Polymerase II General Transcription Initiation Factor Binding Cellular Response To Testosterone Stimulus Type II Pneumocyte Differentiation DNA Replication-dependent Chromatin Assembly Forebrain Neuron Fate Commitment Lateral Sprouting From An Epithelium Epithelial Cell Differentiation Involved In Prostate Gland Development Type B Pancreatic Cell Differentiation Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription Regulator Complex Estrogen Response Element Binding Cerebellar Purkinje Cell Layer Development Transcription Cis-regulatory Region Binding Genitalia Morphogenesis	Germ-line Stem Cell Division Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Neuron Differentiation Nucleus Male Germ-line Stem Cell Asymmetric Division Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Respiratory Basal Cell Differentiation Alveolar Secondary Septum Development Fibrillar Center Positive Regulation Of DNA-binding Transcription Factor Activity Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Positive Regulation Of Dopaminergic Neuron Differentiation Epithelial Cell Maturation Involved In Prostate Gland Development Prostate Gland Stromal Morphogenesis Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development DNA Synthesis Involved In Mitotic DNA Replication Thymidine Biosynthetic Process Pyrimidine-containing Compound Metabolic Process Thymidine Kinase Activity Base-excision Repair, AP Site Formation Via Deaminated Base Removal Uracil DNA N-glycosylase Activity Double-stranded RNA Binding 2'-5'-oligoadenylate Synthetase Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Neuron Differentiation Regulation Of DNA-binding Transcription Factor Activity Intercellular Canaliculus Thymidine Metabolic Process Hydrolase Activity, Hydrolyzing N-glycosyl Compounds Positive Regulation Of RNA Metabolic Process Depyrimidination Interleukin-27-mediated Signaling Pathway Skeletal Muscle Acetylcholine-gated Channel Clustering Mesenchymal-epithelial Cell Signaling Epithelial Cell Differentiation Involved In Prostate Gland Development Deoxyribonucleoside Monophosphate Biosynthetic Process Negative Regulation Of Apoptotic Process Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Single Strand Break Repair Negative Regulation Of Programmed Cell Death Positive Regulation Of RIG-I Signaling Pathway Transcription Cis-regulatory Region Binding Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Asymmetric Cell Division Dorsal/ventral Neural Tube Patterning Pyrimidine Nucleoside Metabolic Process
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