FOXA1 and TLE1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
41

Data Source:
BioGRID (two hybrid)

		FOXA1	TLE1
Description		forkhead box A1	TLE family member 1, transcriptional corepressor
Image
GO Annotations	Cellular Component	Chromatin Fibrillar Center Nucleus Nucleoplasm Microvillus	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Beta-catenin-TCF Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Domain Specific Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding Identical Protein Binding DNA-binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Smoothened Signaling Pathway Anatomical Structure Morphogenesis Regulation Of Gene Expression Negative Regulation Of Epithelial To Mesenchymal Transition Dorsal/ventral Neural Tube Patterning Cell Differentiation Neuron Differentiation Lung Development Response To Estradiol Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Tube Morphogenesis Hormone Metabolic Process Glucose Homeostasis Positive Regulation Of Apoptotic Process Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Formation Involved In Morphogenesis Neuron Fate Specification Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Cell Cycle Lung Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis Lung Epithelial Cell Differentiation Secretory Columnal Luminar Epithelial Cell Differentiation Involved In Prostate Glandular Acinus Development Mesenchymal-epithelial Cell Signaling Involved In Prostate Gland Development Prostate Gland Epithelium Morphogenesis Prostate Gland Stromal Morphogenesis Epithelial Cell Maturation Involved In Prostate Gland Development Alveolar Secondary Septum Development Connective Tissue Development Dopaminergic Neuron Differentiation Respiratory Basal Cell Differentiation Positive Regulation Of MiRNA Transcription Positive Regulation Of Dopaminergic Neuron Differentiation Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Positive Regulation Of Gene Expression Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Anoikis
Pathways		Estrogen-dependent gene expression Formation of axial mesoderm	Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Negative Regulation of CDH1 Gene Transcription
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergy ( 27182965) Chromium levels ( 26025379) Coronary artery aneurysm in Kawasaki disease ( 26434682) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Intraocular pressure ( 29617998) Periodontitis (CDC/AAP) ( 24024966) Self-reported allergy ( 23817569) Tonsillectomy ( 27182965 28928442)	Appendicular lean mass ( 33097823) Forehead morphology ( 29921221) Hippocampal atrophy ( 22745009) Lung adenocarcinoma ( 28604730) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Moderate-to-late spontaneous preterm birth ( 31194736) Rheumatoid arthritis ( 30891314) Schizophrenia ( 25056061) Type 2 diabetes ( 22885922 32499647 30718926 30297969 30054458 28869590 26818947 24509480) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral fat ( 22589738)
Interacting Genes		6 interacting genes: AR H3-4 NKX2-1 ONECUT1 SEZ6L2 TLE1	83 interacting genes: ANXA7 APH1A ARL3 ARL4D ATN1 BARHL1 BCL2L1 BID BTBD2 CCL18 CDK1 CDKN1A CDKN2C CELF3 CRCT1 CSNK2B CTNNB1 DAZAP2 DLEU1 EIF2S2 EN1 ERH ESRRG FOXA1 FOXA2 FOXA3 FOXG1 FUBP1 FXYD6 GADD45A GRB7 GSK3B GSTM4 HES1 HES6 HESX1 HHEX HLA-DQA1 HMGB1 HNF1A HSPE1 IL6ST KDM6A KIAA0408 LEF1 MORF4L2 MPHOSPH6 MSX1 MSX2 NKX2-5 NUDT21 PAFAH1B3 PAX9 PCDHA4 PEX2 PFN1 POLB POLE2 PRDM1 PSMD11 RAP1B RCC1 RNF10 RPA2 RUNX1 RUNX3 SAT1 SERPINB9 SIX1 SIX2 SIX3 SIX6 SMN1 SNRPG TCF3 TCF4 TK1 TLE2 TLX1 TLX2 TSC22D1 UTY ZFP64
Entrez ID		3169	7088
HPRD ID		03801	02557
Ensembl ID		ENSG00000129514	ENSG00000196781
Uniprot IDs		P55317	B4DEF9 Q04724 Q59EF7
PDB IDs		7VOX 8VFY 8VFZ 8VG1 8VG2	1GXR 2CE8 2CE9 4OM2 4OM3 5MWJ
Enriched GO Terms of Interacting Partners?		Leydig Cell Differentiation Developmental Induction Endoderm Development Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Signal Transduction Prostate Induction Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Animal Organ Morphogenesis Negative Regulation Of Cell Communication Anatomical Structure Morphogenesis Epithelial Cell Differentiation Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Negative Regulation Of Signaling Pancreatic D Cell Differentiation Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Globus Pallidus Development Club Cell Differentiation Cerebral Cortex GABAergic Interneuron Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Spermatogonial Cell Division Androgen Binding DNA-binding Transcription Factor Activity Pancreatic A Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Forebrain Dorsal/ventral Pattern Formation Cell Fate Commitment RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Prostatic Bud Formation Locomotory Behavior Lung Saccule Development RNA Polymerase II General Transcription Initiation Factor Binding Cellular Response To Testosterone Stimulus Type II Pneumocyte Differentiation DNA Replication-dependent Chromatin Assembly Forebrain Neuron Fate Commitment Lateral Sprouting From An Epithelium Epithelial Cell Differentiation Involved In Prostate Gland Development Type B Pancreatic Cell Differentiation Prostate Gland Growth Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Transcription Regulator Complex Estrogen Response Element Binding Cerebellar Purkinje Cell Layer Development Transcription Cis-regulatory Region Binding Genitalia Morphogenesis	Sequence-specific Double-stranded DNA Binding Chromatin Developmental Process Nucleus DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cis-regulatory Region Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Animal Organ Development Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Negative Regulation Of Developmental Process Sequence-specific DNA Binding Pattern Specification Process Positive Regulation Of Biosynthetic Process Regulation Of Gene Expression Cell Differentiation DNA-binding Transcription Factor Activity Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Regionalization Negative Regulation Of DNA-templated Transcription Cellular Developmental Process Negative Regulation Of RNA Biosynthetic Process Cell Population Proliferation Regulation Of Macromolecule Metabolic Process Regulation Of Cell Population Proliferation Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Mesenchymal Cell Differentiation Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Developmental Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Transcription Corepressor Binding
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