BPTF and H3F3A

Number of citations of the paper that reports this interaction (PMID 16728976)
287

Data Source:
HPRD (in vitro)

		BPTF	H3F3A
Gene Name		bromodomain PHD finger transcription factor	H3 histone, family 3A
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm NURF Complex Extracellular Vesicular Exosome	Nuclear Chromosome Nuclear Nucleosome Extracellular Region Nucleus Nucleoplasm Protein Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding DNA-dependent ATPase Activity Transcription Factor Binding Zinc Ion Binding Sequence-specific DNA Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Protein Binding Nucleosomal DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Placenta Development Chromatin Remodeling Transcription, DNA-templated Regulation Of Transcription, DNA-templated Brain Development Endoderm Development Anterior/posterior Pattern Specification Positive Regulation Of Transcription, DNA-templated	Chromatin Silencing At RDNA DNA Replication-independent Nucleosome Assembly Blood Coagulation Gene Expression Positive Regulation Of Cell Growth DNA Methylation On Cytosine Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic
Pathways			RNA Polymerase I Chain Elongation RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription Mitotic Prophase Regulatory RNA pathways RNA Polymerase I Promoter Clearance Cellular Senescence Signaling by Wnt M Phase Amyloids NoRC negatively regulates rRNA expression RNF mutants show enhanced WNT signaling and proliferation XAV939 inhibits tankyrase, stabilizing AXIN DNA methylation Transcriptional regulation by small RNAs Meiotic recombination misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling RNA Polymerase I Transcription formation of the beta-catenin:TCF transactivating complex Epigenetic regulation of gene expression Senescence-Associated Secretory Phenotype (SASP) Negative epigenetic regulation of rRNA expression Factors involved in megakaryocyte development and platelet production PRC2 methylates histones and DNA Cell Cycle, Mitotic Oxidative Stress Induced Senescence TCF dependent signaling in response to WNT RNA Polymerase I Promoter Opening SIRT1 negatively regulates rRNA Expression Signaling by WNT in cancer Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Lung adenocarcinoma ( 22797724) Lung cancer ( 23143601)
Protein-Protein Interactions		9 interactors: H3F3A HIST1H4I HIST3H3 KEAP1 MAZ NFE2L2 SMAD2 SMAD3 SQSTM1	25 interactors: ASF1A ASF1B BPTF BRD1 CABIN1 CARM1 CBX3 CHD1 CREBBP DAXX KAT2B KMT2A MAPK9 NOS3 PARP10 SETD7 SMARCA1 SMARCA4 SMARCA5 SS18 SSRP1 SUPT16H TLE2 UHRF1 ZMYND11
Entrez ID		2186	3020
HPRD ID		03490	03082
Ensembl ID		ENSG00000171634	ENSG00000163041
Uniprot IDs		Q12830	B2R4P9 P84243
PDB IDs		2F6J 2F6N 2FSA 2FUI 2FUU 2RI7 3QZS 3QZT 3QZV 3UV2	2L43 3ASK 3ASL 3AV2 3JVK 3MUK 3MUL 3QL9 3QLA 3QLC 4GNE 4GNF 4GNG 4GU0 4GUR 4GUS 4GY5 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4L58
Enriched GO Terms of Interacting Partners?		Gene Silencing Proteasomal Ubiquitin-independent Protein Catabolic Process Regulation Of Gene Expression, Epigenetic Primary MiRNA Processing SMAD Protein Complex Assembly Paraxial Mesoderm Morphogenesis Regulation Of Transcription, DNA-templated DNA Methylation On Cytosine Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Chromatin Silencing At RDNA Nodal Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Protein Complex Assembly Embryonic Foregut Morphogenesis Foregut Morphogenesis Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Paraxial Mesoderm Development Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Production Of MiRNAs Involved In Gene Silencing By MiRNA Transcription Initiation From RNA Polymerase II Promoter Cellular Nitrogen Compound Metabolic Process Pericardium Development Gene Expression Signal Transduction Involved In Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Macromolecular Complex Assembly Activin Receptor Signaling Pathway Positive Regulation Of Epithelial To Mesenchymal Transition Nitrogen Compound Metabolic Process DNA-templated Transcription, Initiation Chromatin Silencing DNA Replication-independent Nucleosome Assembly Gene Silencing By MiRNA Cellular Response To DsRNA Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Posttranscriptional Gene Silencing Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process SMAD Protein Signal Transduction Positive Regulation Of Stem Cell Differentiation Regulation Of Epithelial To Mesenchymal Transition Transcription From RNA Polymerase II Promoter Embryonic Cranial Skeleton Morphogenesis DNA Methylation	Chromatin Organization Chromatin Modification Chromosome Organization Organelle Organization Transcription, DNA-templated RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process RNA Metabolic Process Chromatin Remodeling Gene Expression Biosynthetic Process Regulation Of Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleosome Organization Chromatin Assembly Or Disassembly Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Histone Modification Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Cellular Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process DNA Replication-independent Nucleosome Assembly Histone Acetylation Internal Peptidyl-lysine Acetylation Peptidyl-lysine Acetylation Nucleosome Assembly Internal Protein Amino Acid Acetylation Peptidyl-lysine Modification Protein Acetylation Chromatin Assembly Negative Regulation Of Cellular Metabolic Process DNA Conformation Change Negative Regulation Of Biosynthetic Process Protein-DNA Complex Assembly Negative Regulation Of Transcription, DNA-templated Regulation Of Cellular Process Viral Process
Tagcloud ?		13q33 col4a1 col4a2 d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants	36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies
Tagcloud (Difference) ?		13q33 col4a1 col4a2 d13s1315 d13s158 d13s278 d13s285 d13s779 d13s796 e2f ets flanking genomatix heterozygosity hif1 ing ing1 loh matinspector microdeletion nrsf rel softwares sox sox1 tfsearch tsg tsgs warrants	36me3 atrx code combinatorial commonest daxx g34r g34v gbms global h3k h3k27me3 h3k36me3 h3k4me3 h3k9me3 highlights hist1h3b idh1 innovative k27m mark marks notably opportunity pediatric polycomb tailored trimethylation underlies
Tagcloud (Intersection) ?