CAPZA1 and UCHL5

Number of citations of the paper that reports this interaction (PubMedID 21800051)
0

Data Source:
BioGRID (pull down)

		CAPZA1	UCHL5
Description		capping actin protein of muscle Z-line subunit alpha 1	ubiquitin C-terminal hydrolase L5
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Cortical Cytoskeleton Extracellular Exosome WASH Complex	Proteasome Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Ino80 Complex
	Molecular Function	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding	RNA Binding Cysteine-type Deubiquitinase Activity Endopeptidase Inhibitor Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteasome Binding
	Biological Process	Actin Cytoskeleton Organization Cell Junction Assembly Barbed-end Actin Filament Capping Actin Filament Capping Protein-containing Complex Assembly	Telomere Maintenance Regulation Of DNA Replication DNA Repair Regulation Of DNA Repair DNA Recombination Chromatin Remodeling Proteolysis Ubiquitin-dependent Protein Catabolic Process DNA Damage Response Protein Deubiquitination Lateral Ventricle Development Midbrain Development Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of DNA Repair Positive Regulation Of Smoothened Signaling Pathway Positive Regulation Of DNA-templated Transcription Regulation Of Embryonic Development Forebrain Morphogenesis Regulation Of Cell Cycle Regulation Of DNA Strand Elongation Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Telomere Maintenance In Response To DNA Damage
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	Downregulation of TGF-beta receptor signaling UCH proteinases UCH proteinases
Drugs
Diseases
GWAS		Blood pressure ( 21572416) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Diastolic blood pressure ( 26390057 27618452 27841878 28739976 30487518) Height ( 25282103) Hypertension ( 30487518) Intraocular pressure ( 29785010 29617998) Mean arterial pressure ( 30487518) Mean platelet volume ( 32888494) Platelet count ( 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30487518 28739976 27841878 27618452) Total cholesterol levels ( 30275531)	Cannabis dependence ( 21668797)
Interacting Genes		7 interacting genes: ACTB CD2AP CEBPA S100A1 S100B SH3KBP1 UCHL5	104 interacting genes: ACTN4 ADRM1 ANP32B ANP32E ANXA1 ANXA4 ANXA7 ANXA8 ANXA8L1 APP ARG1 ASPRV1 AXIN1 CALM1 CAP1 CAPZA1 CASP14 CDSN CFL1 CSTA DSC1 DSC3 DSP DUSP14 E2F1 E2F2 E2F3 EEF1G EEF2 EIF4A1 EPPK1 FLG GSTM3 H4C1 H4C11 H4C12 H4C13 H4C14 H4C15 H4C16 H4C2 H4C3 H4C4 H4C5 H4C6 H4C8 H4C9 HAUS7 HBA1 HBA2 HBB HSPB1 IDE IGHG1 IVL KDM1A KRT12 KRT19 KRT26 KRT28 KRT73 KRT78 KRT80 LMNA MAP3K1 NACA OGT PJA1 PKM PKP1 PLA2G2A PNP POF1B PRDX6 PSMD8 RAB7A RBCK1 RFFL RNF4 S100A14 S100A16 S100A7 SERPINB12 SERPINB3 SERPINB5 SET SMAD2 SMAD3 SMAD7 TCF7 TGM3 TPI1 TRIM27 TRIM46 TRIM54 TRIM55 TRIM63 TUBA4A TXN TXN2 UBC USP28 YWHAZ ZBED1
Entrez ID		829	51377
HPRD ID		03347	10293
Ensembl ID		ENSG00000116489	ENSG00000116750
Uniprot IDs		P52907	Q5LJA5 Q9Y5K5
PDB IDs		1MQ1 1MWN 7T5Q 8F8Q	3A7S 3IHR 3RII 3RIS 3TB3 4UEL 4UEM 4UF5 4UF6 4WLP
Enriched GO Terms of Interacting Partners?		Regulation Of Multicellular Organismal Process S100 Protein Binding Cell-cell Junction Maintenance Of Blood-brain Barrier Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Substantia Nigra Development Protein-containing Complex Tau Protein Binding Positive Regulation Of Multicellular Organismal Process Identical Protein Binding Positive Regulation Of Immune System Process Neural Nucleus Development Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Calcium-dependent Protein Binding Actin Filament Structural Constituent Of Cytoskeleton Multicellular Organismal-level Homeostasis Regulation Of Norepinephrine Uptake Response To Vitamin B2 Liver Development C/EBP Complex Ruffle SH3 Domain Binding Positive Regulation Of Developmental Process Memory Developmental Cell Growth Positive Regulation Of DNA Repair Nuclear Matrix Transporter Regulator Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Response To Glucocorticoid Regulation Of Cell Shape Developmental Growth Involved In Morphogenesis Regulation Of Transepithelial Transport Axonogenesis Regulation Of Cell Activation White Fat Cell Proliferation Response To Corticosteroid Response To Hormone System Process Renal Albumin Absorption Response To Glial Cell Derived Neurotrophic Factor Negative Regulation Of Cell Differentiation Protein Localization To Adherens Junction Dense Body	CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Negative Regulation Of Megakaryocyte Differentiation Extracellular Exosome Regulation Of Megakaryocyte Differentiation Protein Localization To Chromosome, Centromeric Region Protein Localization To Chromatin Nucleosome Assembly Cornified Envelope Nucleosome Organization Structural Constituent Of Chromatin Negative Regulation Of Myeloid Cell Differentiation Protein Localization To Chromosome Nucleosome Protein-DNA Complex Assembly Telomere Organization Protein-containing Complex Chromosome, Telomeric Region Negative Regulation Of Cell Differentiation Intermediate Filament Organization Chromatin Remodeling Regulation Of Myeloid Cell Differentiation Structural Constituent Of Skin Epidermis Regulation Of Hemopoiesis Chromatin Organization Extracellular Region Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Negative Regulation Of Developmental Process Desmosome Regulation Of Cell Development Organelle Organization Peptide Cross-linking Regulation Of Cell Differentiation Protein Heterodimerization Activity Intermediate Filament Keratin Filament Keratinocyte Differentiation Supramolecular Fiber Organization Protein Localization To Organelle RNA Binding Chromosome Organization Regulation Of Developmental Process Regulation Of Multicellular Organismal Development Regulation Of Multicellular Organismal Process Nucleus Regulation Of Immune System Process Epidermal Cell Differentiation Haptoglobin Binding
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