CAPZA1 and S100A1

Number of citations of the paper that reports this interaction (PMID 9803314)
6

Data Source:
HPRD (in vitro)

		CAPZA1	S100A1
Gene Name		capping protein (actin filament) muscle Z-line, alpha 1	S100 calcium binding protein A1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Extracellular Vesicular Exosome WASH Complex	Nucleus Sarcoplasmic Reticulum Z Disc M Band Neuron Projection Protein Complex
	Molecular Function	Actin Binding Protein Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Protein Complex Assembly Movement Of Cell Or Subcellular Component Blood Coagulation Innate Immune Response Barbed-end Actin Filament Capping	Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Factors involved in megakaryocyte development and platelet production Advanced glycosylation endproduct receptor signaling Innate Immune System
Drugs			Olopatadine
Diseases
GWAS		Blood pressure ( 21572416)
Protein-Protein Interactions		7 interactors: ACTB CD2AP HSPA8 S100A1 S100B SH3KBP1 UCHL5	24 interactors: ACTA1 AGER ANXA6 ATP2A2 CACYBP CAPZA1 DES FKBP4 GFAP GJA1 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM RYR1 S100A2 S100A4 S100B S100P SYN1
Entrez ID		829	6271
HPRD ID		03347	01489
Ensembl ID		ENSG00000116489	ENSG00000160678
Uniprot IDs		P52907	P23297
PDB IDs		1MQ1 1MWN	2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX
Enriched GO Terms of Interacting Partners?		Midbrain Development Substantia Nigra Development 'de Novo' Posttranslational Protein Folding Central Nervous System Development 'de Novo' Protein Folding Neural Nucleus Development Cellular Response To Stimulus Nervous System Development Cell Projection Organization Locomotion Negative Regulation Of Fibril Organization Axonogenesis Axon Development Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Voltage-gated Calcium Channel Activity Response To Stimulus Neuron Projection Morphogenesis Negative Regulation Of Transforming Growth Factor Beta1 Production Regulation Of Fibril Organization Cell Morphogenesis Involved In Differentiation Regulation Of Cell Shape Signaling Brain Development Negative Regulation Of Skeletal Muscle Cell Differentiation Cell Communication Head Development Regulation Of Cellular Component Organization Neuron Projection Development Clathrin Coat Disassembly Cell Projection Morphogenesis Cell Part Morphogenesis Negative Regulation Of Transforming Growth Factor Beta Production Enzyme Linked Receptor Protein Signaling Pathway Neuron Development System Development Cell Morphogenesis Protein Folding Anatomical Structure Morphogenesis Response To Methylmercury Neuron Differentiation Substrate-dependent Cell Migration, Cell Extension Multicellular Organismal Development Axon Guidance Anatomical Structure Development Regulation Of Skeletal Muscle Cell Differentiation Chaperone Mediated Protein Folding Requiring Cofactor Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of MRNA Splicing, Via Spliceosome Protein Refolding	Muscle System Process Response To Abiotic Stimulus Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Protein Complex Assembly Sarcoplasmic Reticulum Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Muscle Contraction Relaxation Of Cardiac Muscle Regulation Of Striated Muscle Contraction Glycogen Catabolic Process Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Polysaccharide Catabolic Process Calcium Ion Transport Relaxation Of Muscle Striated Muscle Tissue Development Negative Regulation Of Heart Contraction Skeletal Muscle Fiber Development Response To Hormone Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Response To Metal Ion Muscle Tissue Development Cellular Component Assembly Myotube Cell Development Regulation Of Cellular Localization Cellular Carbohydrate Catabolic Process Regulation Of The Force Of Heart Contraction Actin-myosin Filament Sliding Muscle Filament Sliding Response To Wounding Regulation Of Ion Homeostasis Regulation Of Actin Filament-based Process Cellular Metal Ion Homeostasis Cellular Response To Alkaloid Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Astrocyte Differentiation Cytosolic Calcium Ion Homeostasis Cellular Cation Homeostasis Actin-mediated Cell Contraction Cellular Ion Homeostasis Response To Peptide Hormone Cardiac Conduction Tissue Development Negative Regulation Of Striated Muscle Tissue Development Steroid Hormone Receptor Complex Assembly Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Positive Regulation Of Schwann Cell Proliferation
Tagcloud ?		cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6	ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Difference) ?		cgh cghs cnv coherent col20a1 csde1 csnk1e dennd2d derive discerning discriminative gpr18 han hbxip identifiable ikzf1 mcoln2 microarrays mrpl20 rcan3 rwdd3 scrn1 signatures statuses supervised taiwanese trim45 wars2 zmym6	ablation ad ascertain astrocytosis burden collectively demonstration detrimental elucidated gfap gsk3beta iba1 identifies indirectly microgliosis modulates neuroinflammation normalizing pathobiology pc12 plaque po4 psapp ryanodine ryr sensor twelve undetectable uses
Tagcloud (Intersection) ?