CAPZA1 and S100A1

Number of citations of the paper that reports this interaction (PubMedID 9803314)
0

Data Source:
HPRD (in vitro)

		CAPZA1	S100A1
Description		capping actin protein of muscle Z-line subunit alpha 1	S100 calcium binding protein A1
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Cortical Cytoskeleton Extracellular Exosome WASH Complex	Extracellular Region Nucleus Nucleoplasm Cytoplasm Mitochondrion Golgi Apparatus Cytosol Sarcoplasmic Reticulum Z Disc M Band A Band I Band Protein-containing Complex
	Molecular Function	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding	Calcium Ion Binding Protein Binding Identical Protein Binding Protein Homodimerization Activity S100 Protein Binding Metal Ion Binding Calcium-dependent Protein Binding ATPase Binding
	Biological Process	Actin Cytoskeleton Organization Cell Junction Assembly Barbed-end Actin Filament Capping Actin Filament Capping Protein-containing Complex Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Heart Contraction Substantia Nigra Development Intracellular Signal Transduction Vasodilation Positive Regulation Of Sprouting Angiogenesis
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production	ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand
Drugs			Olopatadine
Diseases
GWAS		Blood pressure ( 21572416) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Diastolic blood pressure ( 26390057 27618452 27841878 28739976 30487518) Height ( 25282103) Hypertension ( 30487518) Intraocular pressure ( 29785010 29617998) Mean arterial pressure ( 30487518) Mean platelet volume ( 32888494) Platelet count ( 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30487518 28739976 27841878 27618452) Total cholesterol levels ( 30275531)
Interacting Genes		7 interacting genes: ACTB CD2AP CEBPA S100A1 S100B SH3KBP1 UCHL5	36 interacting genes: ACTA1 AGER ANXA6 ATP2A2 BEX3 BIK CACYBP CAPZA1 CEP20 CLCF1 CNTF CTF1 DES FKBP4 GFAP GJA1 IFNB1 IL11 MDM2 NIF3L1 PGM1 PLB1 PLEKHF2 PLN PPID PYGM REL RYR1 S100A2 S100A3 S100A4 S100B S100P S100Z SYN1 TP53
Entrez ID		829	6271
HPRD ID		03347	01489
Ensembl ID		ENSG00000116489	ENSG00000160678
Uniprot IDs		P52907	A0A0S2Z4H2 P23297
PDB IDs		1MQ1 1MWN 7T5Q 8F8Q	2L0P 2LHL 2LLS 2LLT 2LLU 2LP2 2LP3 2LUX 2M3W 5K89
Enriched GO Terms of Interacting Partners?		Regulation Of Multicellular Organismal Process S100 Protein Binding Cell-cell Junction Maintenance Of Blood-brain Barrier Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Substantia Nigra Development Protein-containing Complex Tau Protein Binding Positive Regulation Of Multicellular Organismal Process Identical Protein Binding Positive Regulation Of Immune System Process Neural Nucleus Development Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Calcium-dependent Protein Binding Actin Filament Structural Constituent Of Cytoskeleton Multicellular Organismal-level Homeostasis Regulation Of Norepinephrine Uptake Response To Vitamin B2 Liver Development C/EBP Complex Ruffle SH3 Domain Binding Positive Regulation Of Developmental Process Memory Developmental Cell Growth Positive Regulation Of DNA Repair Nuclear Matrix Transporter Regulator Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Response To Glucocorticoid Regulation Of Cell Shape Developmental Growth Involved In Morphogenesis Regulation Of Transepithelial Transport Axonogenesis Regulation Of Cell Activation White Fat Cell Proliferation Response To Corticosteroid Response To Hormone System Process Renal Albumin Absorption Response To Glial Cell Derived Neurotrophic Factor Negative Regulation Of Cell Differentiation Protein Localization To Adherens Junction Dense Body	Calcium-dependent Protein Binding S100 Protein Binding Transition Metal Ion Binding Identical Protein Binding Calcium Ion Binding Calcium Ion-transporting ATPase Complex Negative Regulation Of Blood Circulation Regulation Of Blood Circulation Regulation Of System Process Cell Surface Receptor Signaling Pathway Via JAK-STAT Cellular Response To Actinomycin D Cell Surface Receptor Signaling Pathway Via STAT Cell Body Response To Actinomycin D Cellular Response To UV-C Ciliary Neurotrophic Factor Receptor Binding Sarcoplasmic Reticulum Membrane Positive Regulation Of Cell Population Proliferation Regulation Of Cardiac Muscle Cell Membrane Potential Cytokine Activity Intercalated Disc Muscle System Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cellular Response To Antibiotic Negative Regulation Of ATP-dependent Activity RAGE Receptor Binding Developmental Process Relaxation Of Cardiac Muscle Response To Hypoxia Cell Activation Response To UV-C Sarcoplasmic Reticulum Response To Decreased Oxygen Levels Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Sarcoplasmic Reticulum Calcium Ion Transport Modulation Of Chemical Synaptic Transmission Regulation Of Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Response To Oxygen Levels Astrocyte Activation Astrocyte Development Intracellular Calcium Ion Homeostasis Regulation Of Programmed Cell Death Regulation Of Heart Contraction Relaxation Of Muscle Cellular Response To UV Negative Regulation Of Heart Contraction Circadian Behavior Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Rhythmic Behavior
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