CAPZA1

Description		capping actin protein of muscle Z-line subunit alpha 1
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GO Annotations	Cellular Component	Extracellular Region Cytoplasm Cytosol Cytoskeleton F-actin Capping Protein Complex Actin Cytoskeleton Cortical Cytoskeleton Extracellular Exosome WASH Complex
	Molecular Function	Actin Binding Protein Binding Cadherin Binding Actin Filament Binding
	Biological Process	Actin Cytoskeleton Organization Cell Junction Assembly Barbed-end Actin Filament Capping Actin Filament Capping Protein-containing Complex Assembly
Pathways		MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Advanced glycosylation endproduct receptor signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation Sensory processing of sound by inner hair cells of the cochlea Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production
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Diseases
GWAS		Blood pressure ( 21572416) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Cortical volume ( 32963231) Diastolic blood pressure ( 26390057 27618452 27841878 28739976 30487518) Height ( 25282103) Hypertension ( 30487518) Intraocular pressure ( 29785010 29617998) Mean arterial pressure ( 30487518) Mean platelet volume ( 32888494) Platelet count ( 27863252) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 30487518 28739976 27841878 27618452) Total cholesterol levels ( 30275531)
Interacting Genes		7 interacting genes: ACTB CD2AP CEBPA S100A1 S100B SH3KBP1 UCHL5
Entrez ID		829
HPRD ID		03347
Ensembl ID		ENSG00000116489
Uniprot IDs		P52907
PDB IDs		1MQ1 1MWN 7T5Q 8F8Q
Enriched GO Terms of Interacting Partners?		Regulation Of Multicellular Organismal Process S100 Protein Binding Cell-cell Junction Maintenance Of Blood-brain Barrier Regulation Of Multicellular Organismal Development Regulation Of Developmental Process Substantia Nigra Development Protein-containing Complex Tau Protein Binding Positive Regulation Of Multicellular Organismal Process Identical Protein Binding Positive Regulation Of Immune System Process Neural Nucleus Development Positive Regulation Of Cell Activation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Calcium-dependent Protein Binding Actin Filament Structural Constituent Of Cytoskeleton Multicellular Organismal-level Homeostasis Regulation Of Norepinephrine Uptake Response To Vitamin B2 Liver Development C/EBP Complex Ruffle SH3 Domain Binding Positive Regulation Of Developmental Process Memory Developmental Cell Growth Positive Regulation Of DNA Repair Nuclear Matrix Transporter Regulator Activity Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Response To Glucocorticoid Regulation Of Cell Shape Developmental Growth Involved In Morphogenesis Regulation Of Transepithelial Transport Axonogenesis Regulation Of Cell Activation White Fat Cell Proliferation Response To Corticosteroid Response To Hormone System Process Renal Albumin Absorption Response To Glial Cell Derived Neurotrophic Factor Negative Regulation Of Cell Differentiation Protein Localization To Adherens Junction Dense Body
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