Wiki-Pi
About
Search
People
Updates
Search
CAPNS1 and ARHGEF6
Number of citations of the paper that reports this interaction (PubMedID
15611136
)
0
Data Source:
HPRD
(two hybrid, in vivo)
CAPNS1
ARHGEF6
Description
calpain small subunit 1
Rac/Cdc42 guanine nucleotide exchange factor 6
Image
GO Annotations
Cellular Component
Cytoplasm
Cytosol
Plasma Membrane
Membrane
Extracellular Exosome
Calpain Complex
Cytoplasm
Cytosol
Cell-cell Junction
Lamellipodium
Cell Projection
Molecular Function
Calcium-dependent Cysteine-type Endopeptidase Activity
Calcium Ion Binding
Protein Binding
Metal Ion Binding
Guanyl-nucleotide Exchange Factor Activity
GTPase Activator Activity
Protein Binding
Biological Process
Proteolysis
Positive Regulation Of Cell Population Proliferation
Regulation Of Macroautophagy
Apoptotic Process
JNK Cascade
Lamellipodium Assembly
Pathways
Degradation of the extracellular matrix
Degradation of the extracellular matrix
Formation of the cornified envelope
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells
NRAGE signals death through JNK
G alpha (12/13) signalling events
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
G beta:gamma signalling through CDC42
CDC42 GTPase cycle
RAC1 GTPase cycle
RHOU GTPase cycle
Drugs
PD150606
Diseases
Non-syndromic X-linked mental retardation
GWAS
Autism spectrum disorder (
34069769
)
Breast cancer (
29059683
)
Interacting Genes
21 interacting genes:
AGTRAP
ARHGEF6
ARR3
ATP5MF
CAPN1
CAPN2
CAST
CDC42
CDK4
DRG1
F2RL1
GET4
GNB2
IL2RG
KCTD7
LRRCC1
PPARGC1A
RAB1A
STAT3
TERF1
TRAF5
36 interacting genes:
ADAM15
ARAP3
ARHGEF7
BMPR1B
CAPNS1
CBFA2T3
CCDC33
CDC42
EPHB2
GIT1
GOLGA2
GPRASP2
HSF2BP
KRT27
NUTM1
PAK1
PAK2
PAK3
PARVB
PNMA1
POU6F2
RWDD2A
SH2D1A
SH3GL3
SIRPA
SMAD1
SMAD2
SMAD3
TGFBR1
TGFBR2
TMEM108
TP53BP2
TRAF2
TRIM54
YWHAG
ZNF580
Entrez ID
826
9459
HPRD ID
00240
02226
Ensembl ID
ENSG00000126247
ENSG00000129675
Uniprot IDs
A0A0C4DGQ5
P04632
B7Z3C7
Q15052
Q8N4Q3
PDB IDs
1KFU
1KFX
4PHJ
4PHK
4PHM
4WQ2
4WQ3
5D69
6QLB
1UJY
1WYR
Enriched GO Terms of Interacting Partners
?
Calpain Complex
Calcium-dependent Cysteine-type Endopeptidase Activity
Positive Regulation Of Pseudopodium Assembly
Positive Regulation Of Endocytosis
Thioesterase Binding
Positive Regulation Of Phagocytosis
Positive Regulation Of Interleukin-8 Production
Interleukin-15-mediated Signaling Pathway
Interleukin-2-mediated Signaling Pathway
Interleukin-9-mediated Signaling Pathway
Cytosol
Pseudopodium
Regulation Of Interleukin-8 Production
Cytoplasm
Positive Regulation Of Cellular Component Organization
Regulation Of Phagocytosis
GTPase Activity
Regulation Of Endocytosis
LncRNA Binding
Regulation Of Interleukin-6 Production
Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity
Positive Regulation Of Supramolecular Fiber Organization
Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium
Establishment Of Endothelial Barrier
Positive Regulation Of Interleukin-10 Production
Endothelial Cell Development
Positive Regulation Of Renin Secretion Into Blood Stream
Signal Transduction Involved In Regulation Of Gene Expression
Temperature Homeostasis
Negative Regulation Of Establishment Of Protein Localization To Telomere
Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere
Negative Regulation Of Establishment Of RNA Localization To Telomere
Positive Regulation Of Shelterin Complex Assembly
Enzyme-linked Receptor Protein Signaling Pathway
Response To Growth Factor
Dendritic Spine Development
I-SMAD Binding
Cellular Response To Growth Factor Stimulus
Regulation Of Cytoskeleton Organization
Regulation Of Supramolecular Fiber Organization
Ephrin Receptor Signaling Pathway
SMAD Protein Signal Transduction
SMAD Protein Complex
Trophoblast Cell Migration
Heteromeric SMAD Protein Complex
Embryonic Cranial Skeleton Morphogenesis
Activin Receptor Signaling Pathway
Cell Surface Receptor Signaling Pathway
Transmembrane Receptor Protein Serine/threonine Kinase Activity
Regulation Of Stress Fiber Assembly
Co-SMAD Binding
Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway
Primary MiRNA Processing
Transforming Growth Factor Beta Receptor Signaling Pathway
Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway
SMAD Binding
Protein Kinase Binding
Homomeric SMAD Protein Complex
Positive Regulation Of Stress Fiber Assembly
Regulation Of Actin Cytoskeleton Organization
Dendritic Spine Morphogenesis
Positive Regulation Of Epithelial To Mesenchymal Transition
Regulation Of Microtubule Nucleation
Protein Kinase Activity
Positive Regulation Of Actin Filament Bundle Assembly
Cellular Response To Lectin
Stimulatory C-type Lectin Receptor Signaling Pathway
Paraxial Mesoderm Morphogenesis
Transforming Growth Factor Beta Ligand-receptor Complex
Regulation Of Actin Filament-based Process
Response To Transforming Growth Factor Beta
Immune System Process
Regulation Of Cartilage Development
Protein Serine/threonine Kinase Activity
Regulation Of Cellular Component Organization
Positive Regulation Of Cell Migration
Regulation Of Actin Filament Organization
Response To Cholesterol
Roof Of Mouth Development
Response To Stress
Positive Regulation Of Cell Motility
Regulation Of Organelle Organization
Positive Regulation Of Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?