CAPNS1 and AGTRAP

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		CAPNS1	AGTRAP
Gene Name		calpain, small subunit 1	angiotensin II receptor-associated protein
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Vesicular Exosome	Golgi Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Plasma Membrane Cell Cortex Integral Component Of Membrane Cytoplasmic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding	Angiotensin Type II Receptor Activity Protein Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Proliferation Extracellular Matrix Disassembly Extracellular Matrix Organization	Response To Hypoxia Regulation Of Blood Pressure Angiotensin-activated Signaling Pathway
Pathways		Degradation of the extracellular matrix
Drugs
Diseases
GWAS			Systolic blood pressure ( 19430483)
Protein-Protein Interactions		18 interactors: AGTRAP ARHGEF6 ARR3 ATP5J2 CAPN1 CAPN2 CAST CDK4 DRG1 GET4 GNB2 IL2RG LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5	70 interactors: ACSF2 ADCK3 AGTR1 AGTR2 ALDH18A1 AP3M1 ARAF ARFIP2 BPIFA2 C12orf10 CAPNS1 CD160 CPLX1 CRCT1 DDA1 DDX55 DGCR6 FAM114A1 FAM160A2 FAM64A FARS2 FASTKD3 FATE1 GABARAPL2 GAD1 GAD2 GDNF GNB2L1 GTF3C1 HARS2 HIST1H4G HMGB1 HSCB HSPA4 ISCU KIAA0368 LMO2 LNX1 MCEE MIEF1 MIEF2 MRM1 MTERF3 MUTYH NDRG4 NFU1 NFYB NKG7 PBX3 PCTP PDHX PITPNC1 PTPN9 RMDN2 SENP2 SNX1 SPG21 SSX3 SSX5 STAG3L1 SUCLA2 SYT16 TBRG4 TCEANC2 TFAM TPD52L3 TUBA1B TXN2 ZFYVE21 ZNF391
Entrez ID		826	57085
HPRD ID		00240	16379
Ensembl ID		ENSG00000126247	ENSG00000177674
Uniprot IDs		P04632	Q6RW13
PDB IDs		1KFU 1KFX
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glycolytic Process Signal Transduction Response To Hypoxia Regulation Of Cell Death Cellular Response To Stimulus Signaling Cell Communication Temperature Homeostasis Regulation Of Glycolytic Process Response To Stimulus Regulation Of Apoptotic Process Response To Drug Positive Regulation Of Cell Cycle Process Cellular Response To Nitrite Response To Abiotic Stimulus Positive Regulation Of Cell Cycle Energy Derivation By Oxidation Of Organic Compounds Regulation Of Generation Of Precursor Metabolites And Energy Response To Organic Substance Interleukin-8 Secretion Cargo Loading Into COPII-coated Vesicle Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Interleukin-7-mediated Signaling Pathway Positive Regulation Of ATP Biosynthetic Process Positive Regulation Of Mitochondrial DNA Metabolic Process Cellular Response To Organic Substance Response To Stress Mitotic Cell Cycle Positive Regulation Of Energy Homeostasis Response To Statin Telomeric Loop Formation Age-dependent Telomere Shortening Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Positive Regulation Of Cell Proliferation Response To Organonitrogen Compound Interleukin-8 Production Telomere Maintenance Via Telomere Shortening Interleukin-2-mediated Signaling Pathway Positive Regulation Of Cellular Respiration Cellular Response To Oxygen Levels Respiratory Electron Transport Chain Response To Amino Acid Generation Of Precursor Metabolites And Energy Positive Regulation Of Mitotic Cell Cycle Regulation Of Cellular Process Cell Division Regulation Of Cell Proliferation Regulation Of Protein Metabolic Process Endomembrane System Organization	Succinate Metabolic Process Glutamate Decarboxylation To Succinate Glutamate Metabolic Process Iron-sulfur Cluster Assembly Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Size By Renin-angiotensin Dicarboxylic Acid Metabolic Process Glutamate Catabolic Process Angiotensin-activated Signaling Pathway Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Protein Homooligomerization Positive Regulation Of Mitochondrial Fission Small Molecule Metabolic Process Negative Regulation Of Phagocytosis Regulation Of Mitochondrial Fission Regulation Of Blood Volume By Renin-angiotensin Dicarboxylic Acid Catabolic Process Neurotransmitter Biosynthetic Process Carboxylic Acid Metabolic Process Regulation Of Oxidoreductase Activity Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Protein Oligomerization Regulation Of Renal Sodium Excretion Regulation Of Branching Involved In Ureteric Bud Morphogenesis Carboxylic Acid Catabolic Process Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Organic Acid Metabolic Process Positive Regulation Of Monooxygenase Activity Regulation Of Excretion Exploration Behavior Regulation Of Protein Oligomerization Neurotransmitter Metabolic Process Neurotransmitter Secretion Mitochondrion Organization Ornithine Biosynthetic Process Negative Regulation Of Apoptotic Cell Clearance Succinyl-CoA Pathway Posterior Compartment Specification Anterior Compartment Pattern Formation Aldosterone Secretion Nitrogen Fixation Vasodilation By Angiotensin Involved In Regulation Of Systemic Arterial Blood Pressure L-methylmalonyl-CoA Metabolic Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Positive Regulation Of Embryonic Development Positive Regulation Of Protein Targeting To Membrane Metanephros Morphogenesis Cellular Amino Acid Catabolic Process Cardiac Muscle Tissue Growth Biosynthetic Process
Tagcloud ?		afp buffalo cadaveric calpain cd34 curing facilitates fetoprotein greatest hcc hepatectomy hepatoma implantation invasiveness largest lungs microscopic microvessel modalities occult partial project regeneration remnant resection resections sizes transplantation vegfr2	adrenal alpha1 apelin apln covers ephx2 epoxide genesis gja1 glands hydrolase hypertensive isolating kynu kynureninase kyoto normotensive osteonectin prone rgs2 rising shr shrsp sparc spock2 substrains urotensin uts2 wky
Tagcloud (Difference) ?		afp buffalo cadaveric calpain cd34 curing facilitates fetoprotein greatest hcc hepatectomy hepatoma implantation invasiveness largest lungs microscopic microvessel modalities occult partial project regeneration remnant resection resections sizes transplantation vegfr2	adrenal alpha1 apelin apln covers ephx2 epoxide genesis gja1 glands hydrolase hypertensive isolating kynu kynureninase kyoto normotensive osteonectin prone rgs2 rising shr shrsp sparc spock2 substrains urotensin uts2 wky
Tagcloud (Intersection) ?