CAPNS1 and CAST

Number of citations of the paper that reports this interaction (PubMedID 12684003)
0

Data Source:
HPRD (in vitro)

		CAPNS1	CAST
Description		calpain small subunit 1	calpastatin
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Calpain Complex	Cytoplasm Endoplasmic Reticulum Cytosol Membrane
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Metal Ion Binding	RNA Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Cadherin Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy	Presynaptic Active Zone Organization Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	Degradation of the extracellular matrix Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
Drugs		PD150606	Calcium Artenimol
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alcohol dependence ( 19581569) Appendicular lean mass ( 33097823) Body mass index ( 26426971 29381148) Fish- and plant-related diet ( 32066663) Medication use (agents acting on the renin-angiotensin system) ( 31015401)
Interacting Genes		21 interacting genes: AGTRAP ARHGEF6 ARR3 ATP5MF CAPN1 CAPN2 CAST CDC42 CDK4 DRG1 F2RL1 GET4 GNB2 IL2RG KCTD7 LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5	11 interacting genes: CAPN1 CAPNS1 CASP1 CASP3 CASP7 HTRA1 PPFIA1 PPFIA2 PPFIA3 PPFIA4 SUMO2
Entrez ID		826	831
HPRD ID		00240	00233
Ensembl ID		ENSG00000126247	ENSG00000310517
Uniprot IDs		A0A0C4DGQ5 P04632	A0A6Q8PH20 B7Z6N0 E9PCH5 E9PDE4 P20810 Q59HE3 Q86YM9
PDB IDs		1KFU 1KFX 4PHJ 4PHK 4PHM 4WQ2 4WQ3 5D69 6QLB
Enriched GO Terms of Interacting Partners?		Calpain Complex Calcium-dependent Cysteine-type Endopeptidase Activity Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Endocytosis Thioesterase Binding Positive Regulation Of Phagocytosis Positive Regulation Of Interleukin-8 Production Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Cytosol Pseudopodium Regulation Of Interleukin-8 Production Cytoplasm Positive Regulation Of Cellular Component Organization Regulation Of Phagocytosis GTPase Activity Regulation Of Endocytosis LncRNA Binding Regulation Of Interleukin-6 Production Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Establishment Of Endothelial Barrier Positive Regulation Of Interleukin-10 Production Endothelial Cell Development Positive Regulation Of Renin Secretion Into Blood Stream Signal Transduction Involved In Regulation Of Gene Expression Temperature Homeostasis Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly	Presynaptic Active Zone Protein Poly-ADP-ribosylation Calpain Complex Cysteine-type Peptidase Activity Pyroptotic Inflammatory Response Cellular Response To Staurosporine Peptidase Activity Cysteine-type Endopeptidase Activity Synapse Organization Calcium-dependent Cysteine-type Endopeptidase Activity Fibroblast Apoptotic Process Proteolysis Interleukin-18-mediated Signaling Pathway Cytosol Aspartic-type Endopeptidase Activity Execution Phase Of Apoptosis Plasma Membrane Repair Cell Junction Organization Protein Processing Regulation Of Macroautophagy Cellular Response To Alkaloid Glutamatergic Synapse Cellular Response To Osmotic Stress Leukocyte Apoptotic Process Ceramide Biosynthetic Process Structural Constituent Of Presynapse Epididymosome Protein Metabolic Process Cytoplasm Protein Maturation Response To Lipopolysaccharide Positive Regulation Of Neuron Apoptotic Process Striated Muscle Cell Differentiation Response To Osmotic Stress Response To Molecule Of Bacterial Origin AIM2 Inflammasome Complex Assembly Protease Inhibitor Complex Phospholipase A2 Activator Activity Regulation Of Autophagy Ceramide Metabolic Process Post-translational Protein Modification Endopeptidase Activity Response To Alkaloid Sphingolipid Biosynthetic Process AIM2 Inflammasome Complex IPAF Inflammasome Complex Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Structural Constituent Of Postsynaptic Density Hydrolase Activity Cell Death
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