CAPNS1 and PPARGC1A

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		CAPNS1	PPARGC1A
Description		calpain small subunit 1	PPARG coactivator 1 alpha
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome Calpain Complex	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol PML Body
	Molecular Function	Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Metal Ion Binding	Nucleic Acid Binding DNA Binding Transcription Coregulator Activity Transcription Coactivator Activity RNA Binding Protein Binding Nuclear Receptor Binding Chromatin DNA Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding LncRNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Proteolysis Positive Regulation Of Cell Population Proliferation Regulation Of Macroautophagy	Temperature Homeostasis Intracellular Glucose Homeostasis Response To Dietary Excess Gluconeogenesis Regulation Of DNA-templated Transcription Transcription Initiation At RNA Polymerase II Promoter MRNA Processing Mitochondrion Organization Digestion RNA Splicing Positive Regulation Of Gene Expression Response To Muscle Activity Fatty Acid Oxidation Respiratory Electron Transport Chain Developmental Process Circadian Regulation Of Gene Expression Cellular Response To Oxidative Stress Homeostatic Process Response To Starvation Regulation Of Circadian Rhythm Negative Regulation Of Neuron Apoptotic Process Cellular Respiration Positive Regulation Of Gluconeogenesis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Rhythmic Process Negative Regulation Of Smooth Muscle Cell Proliferation Protein Stabilization Brown Fat Cell Differentiation Neuron Apoptotic Process Adipose Tissue Development Protein-containing Complex Assembly Energy Homeostasis Positive Regulation Of Cold-induced Thermogenesis
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cells	PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Transcriptional activation of mitochondrial biogenesis Activation of PPARGC1A (PGC-1alpha) by phosphorylation Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Heme signaling MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 Regulation of MITF-M dependent genes involved in metabolism Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs		PD150606
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301) Coffee consumption ( 31046077) Cognitive decline rate in late mild cognitive impairment ( 26252872) Corneal astigmatism ( 29422769) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Essential tremor ( 27797806) Estimated glomerular filtration rate ( 31152163 31015462) Femur bone mineral density x serum urate levels interaction ( 34046847) Hematocrit ( 32888494) Hemoglobin ( 32888494) Intralaminar thalamic nuclei volume ( 34006833) Lead levels ( 26025379) Molar-incisor hypomineralization ( 23918034) PR interval ( 32439900) Refractive error ( 32231278) Resting heart rate ( 27798624) Rosacea symptom severity ( 29771307) Schizophrenia ( 30285260) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010)
Interacting Genes		21 interacting genes: AGTRAP ARHGEF6 ARR3 ATP5MF CAPN1 CAPN2 CAST CDC42 CDK4 DRG1 F2RL1 GET4 GNB2 IL2RG KCTD7 LRRCC1 PPARGC1A RAB1A STAT3 TERF1 TRAF5	44 interacting genes: CAPNS1 CDK6 CREBBP ESR1 ESR2 ESRRA ESRRG FBXW7 GSK3B HCFC1 HNF4A LRPPRC MAPK14 MED1 MED12 MED14 MED17 MYBBP1A NCL NCOA1 NCOA6 NDN NR1H4 NR1I2 NR1I3 NR3C1 NRF1 PPARA PPARD PPARG RARB RNF10 RXRA SIRT1 SKP1 SRSF4 SRSF5 SRSF6 THRB TP53 UBC UBE2I USF1 USF2
Entrez ID		826	10891
HPRD ID		00240	05155
Ensembl ID		ENSG00000126247	ENSG00000109819
Uniprot IDs		A0A0C4DGQ5 P04632	D6RBF3 Q9UBK2
PDB IDs		1KFU 1KFX 4PHJ 4PHK 4PHM 4WQ2 4WQ3 5D69 6QLB	1XB7 3B1M 3CS8 3D24 3U9Q 3V9T 3V9V 4QJR 4QK4 5Q0I 5TWO 5UNJ 5Z5S 5Z6S 6AD9 6FZF 6FZP 6IZM 6IZN 6K0T 6KXX 6KXY 6LN4 6MS7 6NWK 6NWL 6T1V 6W9K 6W9L 7E2E 7KHT 7PRV 7PRW 7PRX 8BF1 8DK4 9F7W 9F7X
Enriched GO Terms of Interacting Partners?		Calpain Complex Calcium-dependent Cysteine-type Endopeptidase Activity Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Endocytosis Thioesterase Binding Positive Regulation Of Phagocytosis Positive Regulation Of Interleukin-8 Production Interleukin-15-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-9-mediated Signaling Pathway Cytosol Pseudopodium Regulation Of Interleukin-8 Production Cytoplasm Positive Regulation Of Cellular Component Organization Regulation Of Phagocytosis GTPase Activity Regulation Of Endocytosis LncRNA Binding Regulation Of Interleukin-6 Production Calcium-dependent Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Establishment Of Endothelial Barrier Positive Regulation Of Interleukin-10 Production Endothelial Cell Development Positive Regulation Of Renin Secretion Into Blood Stream Signal Transduction Involved In Regulation Of Gene Expression Temperature Homeostasis Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly	Positive Regulation Of Transcription By RNA Polymerase II Nuclear Receptor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleoplasm Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Nuclear Receptor-mediated Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding Hormone-mediated Signaling Pathway Nucleus Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Chromatin Negative Regulation Of Macromolecule Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Metabolic Process Nuclear Steroid Receptor Activity DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Intracellular Signal Transduction Rhythmic Process Estrogen Response Element Binding Transcription Coactivator Binding Peroxisome Proliferator Activated Receptor Signaling Pathway Nuclear Vitamin D Receptor Binding
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